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Literature DB >> 30254054

Arrestins and G proteins in cellular signaling: The coin has two sides.

Vsevolod V Gurevich¹, Eugenia V Gurevich².

Abstract

Several studies have suggested that arrestin-mediated signaling by GPCRs requires G protein activation; however, in this issue of Science Signaling, Luttrell et al. documented arrestin-dependent activation of ERK1/2 by a number of GPCRs. These studies do not contradict each other, but illustrate the complexity of cellular signaling that cannot and should not be reduced to simplistic models.

Entities: Chemical Disease Gene

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Year: 2018 PMID： 30254054 PMCID： PMC6390952 DOI： 10.1126/scisignal.aav1646

Source DB: PubMed Journal: Sci Signal ISSN： 1945-0877 Impact factor: 8.192

10 in total

Review 1. 'Location, location, location': activation and targeting of MAP kinases by G protein-coupled receptors.

Authors: L M Luttrell
Journal: J Mol Endocrinol Date: 2003-04 Impact factor: 5.098

Review 2. Organization and regulation of mitogen-activated protein kinase signaling pathways.

Authors: T P Garrington; G L Johnson
Journal: Curr Opin Cell Biol Date: 1999-04 Impact factor: 8.382

3. Genetic evidence that β-arrestins are dispensable for the initiation of β₂-adrenergic receptor signaling to ERK.

Authors: Morgan O'Hayre; Kelsie Eichel; Silvia Avino; Xuefeng Zhao; Dana J Steffen; Xiaodong Feng; Kouki Kawakami; Junken Aoki; Karen Messer; Roger Sunahara; Asuka Inoue; Mark von Zastrow; J Silvio Gutkind
Journal: Sci Signal Date: 2017-06-20 Impact factor: 8.192

Review 4. Beta-arrestins and cell signaling.

Authors: Scott M DeWire; Seungkirl Ahn; Robert J Lefkowitz; Sudha K Shenoy
Journal: Annu Rev Physiol Date: 2007 Impact factor: 19.318

Review 5. The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling.

Authors: Yuri K Peterson; Louis M Luttrell
Journal: Pharmacol Rev Date: 2017-07 Impact factor: 25.468

6. Silent scaffolds: inhibition OF c-Jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant.

Authors: Maya Breitman; Seunghyi Kook; Luis E Gimenez; Britney N Lizama; Maria C Palazzo; Eugenia V Gurevich; Vsevolod V Gurevich
Journal: J Biol Chem Date: 2012-04-20 Impact factor: 5.157

7. Peptide mini-scaffold facilitates JNK3 activation in cells.

Authors: Xuanzhi Zhan; Henriette Stoy; Tamer S Kaoud; Nicole A Perry; Qiuyan Chen; Alejandro Perez; Sylvia Els-Heindl; Jack V Slagis; Tina M Iverson; Annette G Beck-Sickinger; Eugenia V Gurevich; Kevin N Dalby; Vsevolod V Gurevich
Journal: Sci Rep Date: 2016-02-12 Impact factor: 4.379

8. Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling.

Authors: Elisa Alvarez-Curto; Asuka Inoue; Laura Jenkins; Sheikh Zahir Raihan; Rudi Prihandoko; Andrew B Tobin; Graeme Milligan
Journal: J Biol Chem Date: 2016-11-16 Impact factor: 5.157

9. Lack of beta-arrestin signaling in the absence of active G proteins.

Authors: Manuel Grundmann; Nicole Merten; Davide Malfacini; Asuka Inoue; Philip Preis; Katharina Simon; Nelly Rüttiger; Nicole Ziegler; Tobias Benkel; Nina Katharina Schmitt; Satoru Ishida; Ines Müller; Raphael Reher; Kouki Kawakami; Ayumi Inoue; Ulrike Rick; Toni Kühl; Diana Imhof; Junken Aoki; Gabriele M König; Carsten Hoffmann; Jesus Gomeza; Jürgen Wess; Evi Kostenis
Journal: Nat Commun Date: 2018-01-23 Impact factor: 14.919

10. Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.

Authors: Louis M Luttrell; Jialu Wang; Bianca Plouffe; Jeffrey S Smith; Lama Yamani; Suneet Kaur; Pierre-Yves Jean-Charles; Christophe Gauthier; Mi-Hye Lee; Biswaranjan Pani; Jihee Kim; Seungkirl Ahn; Sudarshan Rajagopal; Eric Reiter; Michel Bouvier; Sudha K Shenoy; Stéphane A Laporte; Howard A Rockman; Robert J Lefkowitz
Journal: Sci Signal Date: 2018-09-25 Impact factor: 9.517

10 in total

11 in total

Review 10. GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health and Disease.

Authors: Hanne Leysen; Deborah Walter; Bregje Christiaenssen; Romi Vandoren; İrem Harputluoğlu; Nore Van Loon; Stuart Maudsley
Journal: Int J Mol Sci Date: 2021-12-13 Impact factor: 5.923

Arrestins and G proteins in cellular signaling: The coin has two sides.

Review 1. 'Location, location, location': activation and targeting of MAP kinases by G protein-coupled receptors.

Review 2. Organization and regulation of mitogen-activated protein kinase signaling pathways.

3. Genetic evidence that β-arrestins are dispensable for the initiation of β₂-adrenergic receptor signaling to ERK.

Review 4. Beta-arrestins and cell signaling.

Review 5. The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling.

6. Silent scaffolds: inhibition OF c-Jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant.

7. Peptide mini-scaffold facilitates JNK3 activation in cells.

8. Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling.

9. Lack of beta-arrestin signaling in the absence of active G proteins.

10. Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.

Review 1. Many faces of the GPCR-arrestin interaction.

Review 2. Arrestin recruitment and signaling by G protein-coupled receptor heteromers.

3. Phosphorylation barcode-dependent signal bias of the dopamine D1 receptor.

Review 4. Biased GPCR signaling: Possible mechanisms and inherent limitations.

Review 5. GPCR Signaling Regulation: The Role of GRKs and Arrestins.

Review 6. G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub.

Review 7. GRKs as Modulators of Neurotransmitter Receptors.

Review 8. QR code model: a new possibility for GPCR phosphorylation recognition.

Review 9. New Routes in GPCR/β-Arrestin-Driven Signaling in Cancer Progression and Metastasis.

Review 10. GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health and Disease.