Literature DB >> 3025347

T cell-macrophage interactions in the immune response to herpes simplex virus: the significance of interferon-gamma.

J M Seid, M Liberto, L Bonina, K N Leung, A A Nash.   

Abstract

The antiviral properties of a herpex simplex virus type 1-specific 'helper' T cell clone were investigated. The clone was found to be deficient in interleukin 2 production, although it produced interleukin 3 and interferon-gamma upon stimulation with the virus in vitro. Supernatants containing these lymphokines were observed to increase the virocidal activity of macrophages in vitro and furthermore induced these cells to mediate cytotoxic activity against virus-infected target cells. Macrophage activation was linked to the presence of interferon-gamma in the clone supernatant. The implications of these results for protection against this virus in vivo are discussed.

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Year:  1986        PMID： 3025347     DOI： 10.1099/0022-1317-67-12-2799

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  5 in total

1.  Herpes simplex virus selectively induces expression of the CC chemokine RANTES/CCL5 in macrophages through a mechanism dependent on PKR and ICP0.

Authors:  Jesper Melchjorsen; Finn S Pedersen; Søren C Mogensen; Søren R Paludan
Journal:  J Virol       Date:  2002-03       Impact factor: 5.103

2.  Role of virus-specific CD4+ cytotoxic T cells in recovery from mouse hepatitis virus infection.

Authors:  O L Wijburg; M H Heemskerk; A Sanders; C J Boog; N Van Rooijen
Journal:  Immunology       Date:  1996-01       Impact factor: 7.397

3.  Sendai virus pneumonia: evidence for the early recruitment of gamma delta T cells during the disease course.

Authors:  T Ogasawara; M Emoto; K Kiyotani; K Shimokata; T Yoshida; Y Nagai; Y Yoshikai
Journal:  J Virol       Date:  1994-06       Impact factor: 5.103

4.  Analysis of the cytolytic T-lymphocyte response to herpes simplex virus type 1 glycoprotein B during primary and secondary infection.

Authors:  C T Nugent; R M Wolcott; R Chervenak; S R Jennings
Journal:  J Virol       Date:  1994-11       Impact factor: 5.103

5.  Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes.

Authors:  S Jonjić; I Pavić; P Lucin; D Rukavina; U H Koszinowski
Journal:  J Virol       Date:  1990-11       Impact factor: 5.103
  5 in total

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