Literature DB >> 3025220

Protein translocation across the yeast microsomal membrane is stimulated by a soluble factor.

M G Waters, W J Chirico, G Blobel.   

Abstract

We have found that a soluble activity present in the postribosomal supernatant fraction of Saccharomyces cerevisiae stimulates posttranslational translocation of yeast prepro-alpha-factor across yeast microsomal membranes. Stimulation of translocation is not due to a nonspecific affect on ATP levels. The activity is likely to be due to protein(s) as it is destroyed by N-ethylmaleimide, protease, or heat treatment but not by incubation with RNase. Its apparent sedimentation coefficient is approximately 9.6 S.

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Year:  1986        PMID： 3025220      PMCID： PMC2114630          DOI： 10.1083/jcb.103.6.2629

Source DB:  PubMed          Journal:  J Cell Biol        ISSN： 0021-9525            Impact factor:   10.539


  27 in total

1.  Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum.

Authors:  P Walter; G Blobel
Journal:  Nature       Date:  1982-10-21       Impact factor: 49.962

2.  Structure of a yeast pheromone gene (MF alpha): a putative alpha-factor precursor contains four tandem copies of mature alpha-factor.

Authors:  J Kurjan; I Herskowitz
Journal:  Cell       Date:  1982-10       Impact factor: 41.582

3.  Secretory protein translocation across membranes-the role of the "docking protein'.

Authors:  D I Meyer; E Krause; B Dobberstein
Journal:  Nature       Date:  1982-06-24       Impact factor: 49.962

4.  Effect of glucosylation of lipid intermediates on oligosaccharide transfer in solubilized microsomes from Saccharomyces cerevisiae.

Authors:  R B Trimble; J C Byrd; F Maley
Journal:  J Biol Chem       Date:  1980-12-25       Impact factor: 5.157

5.  Biosynthesis of yeast glycoproteins. Processing of the oligosaccharides transferred from dolichol derivatives.

Authors:  A J Parodi
Journal:  J Biol Chem       Date:  1979-10-25       Impact factor: 5.157

6.  Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum.

Authors:  P Walter; G Blobel
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

7.  Secretion in yeast: translocation and glycosylation of prepro-alpha-factor in vitro can occur via an ATP-dependent post-translational mechanism.

Authors:  J A Rothblatt; D I Meyer
Journal:  EMBO J       Date:  1986-05       Impact factor: 11.598

8.  Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.

Authors:  P Walter; G Blobel
Journal:  J Cell Biol       Date:  1981-11       Impact factor: 10.539

9.  Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor.

Authors:  R Gilmore; P Walter; G Blobel
Journal:  J Cell Biol       Date:  1982-11       Impact factor: 10.539

10.  Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.

Authors:  G Blobel; B Dobberstein
Journal:  J Cell Biol       Date:  1975-12       Impact factor: 10.539
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  29 in total

1.  Requirement of different mitochondrial targeting sequences of the yeast mitochondrial transcription factor Mtf1p when synthesized in alternative translation systems.

Authors:  Tapan K Biswas; Godfrey S Getz
Journal:  Biochem J       Date:  2004-10-15       Impact factor: 3.857

Review 2.  Ribonucleoparticle-independent transport of proteins into mammalian microsomes.

Authors:  R Zimmermann; M Zimmermann; H Wiech; G Schlenstedt; G Müller; F Morel; P Klappa; C Jung; W W Cobet
Journal:  J Bioenerg Biomembr       Date:  1990-12       Impact factor: 2.945

3.  A Soluble Protein Factor is Required in Vitro for Membrane Insertion of the Thylakoid Precursor Protein, pLHCP.

Authors:  D R Fulson; K Cline
Journal:  Plant Physiol       Date:  1988-12       Impact factor: 8.340

4.  Membrane integration of in vitro-translated gap junctional proteins: co- and post-translational mechanisms.

Authors:  J T Zhang; M Chen; C I Foote; B J Nicholson
Journal:  Mol Biol Cell       Date:  1996-03       Impact factor: 4.138

5.  Single-amino-acid substitutions within the signal sequence of yeast prepro-alpha-factor affect membrane translocation.

Authors:  D S Allison; E T Young
Journal:  Mol Cell Biol       Date:  1988-05       Impact factor: 4.272

Review 6.  Signal peptidases and signal peptide hydrolases.

Authors:  I K Dev; P H Ray
Journal:  J Bioenerg Biomembr       Date:  1990-06       Impact factor: 2.945

Review 7.  Protein transport and compartmentation in yeast.

Authors:  J Horák
Journal:  Folia Microbiol (Praha)       Date:  1991       Impact factor: 2.099

8.  Requirement of heat-labile cytoplasmic protein factors for posttranslational translocation of OmpA protein precursors into Escherichia coli membrane vesicles.

Authors:  Q P Weng; L L Chen; P C Tai
Journal:  J Bacteriol       Date:  1988-01       Impact factor: 3.490

9.  Soluble factors stimulating secretory protein translocation in bacteria and yeast can substitute for each other.

Authors:  I T Fecycz; G Blobel
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

10.  Identification of an essential Schizosaccharomyces pombe RNA homologous to the 7SL component of signal recognition particle.

Authors:  P Brennwald; X Liao; K Holm; G Porter; J A Wise
Journal:  Mol Cell Biol       Date:  1988-04       Impact factor: 4.272
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