Literature DB >> 30251034

Pregnane glycosides from the bark of Marsdenia cundurango and their cytotoxic activity.

Satoru Tatsuno1, Akihito Yokosuka2, Fusako Hatsuma1, Yuto Mashiko1, Yoshihiro Mimaki1.   

Abstract

Seven new pregnane glycosides (1-7) and eight known compounds (8-15) were isolated from the bark of Marsdenia cundurango (Asclepiadaceae). The structures of 1-7 were determined by spectroscopic analysis, including two-dimension NMR spectroscopy, chemical transformations, and chromatographic analysis of the hydrolyzed products. The isolated compounds 1-15 were evaluated for their cytotoxic activity against HL-60 human leukemia cells, A549 human lung adenocarcinoma cells, and TIG-3 normal human lung cells, including apoptosis-inducing activity of a representative pregnane glycoside in HL-60 cells.

Entities:  

Keywords:  A549 cell line; Apoptosis; Asclepiadaceae; Cytotoxic activity; HL-60 cell line; Marsdenia cundurango; Pregnane glycosides; TIG-3 cell line

Mesh：

Substances：

Year:  2018        PMID： 30251034     DOI： 10.1007/s11418-018-1248-0

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  8 in total

1.  Pregnanes and pregnane glycosides from Marsdenia roylei.

Authors:  Vijay S Gupta; Alok Kumar; Desh Deepak; Anakshi Khare; Naveen K Khare
Journal:  Phytochemistry       Date:  2003-12       Impact factor: 4.072

2.  [Digitanolglycosides. XIX. The structure of kondurangoglycosides A, A1, and C, C1].

Authors:  R Tschesche; H Kohl
Journal:  Tetrahedron       Date:  1968-06       Impact factor: 2.457

3.  Amurensiosides L-P, five new cardenolide glycosides from the roots of Adonis amurensis.

Authors:  Satoshi Kubo; Minpei Kuroda; Akihito Yokosuka; Hiroshi Sakagami; Yoshihiro Mimaki
Journal:  Nat Prod Commun       Date:  2015-01       Impact factor: 0.986

4.  Studies on differentiation inducers. IV. Pregnane derivatives from condurango cortex.

Authors:  K Umehara; M Endoh; T Miyase; M Kuroyanagi; A Ueno
Journal:  Chem Pharm Bull (Tokyo)       Date:  1994-03       Impact factor: 1.645

5.  Further investigation of antitumor condurangoglycosides with C-18 oxygenated aglycone.

Authors:  K Hayashi; K Wada; H Mitsuhashi; H Bando; M Takase; S Terada; Y Koide; T Aiba; T Narita; D Mizuno
Journal:  Chem Pharm Bull (Tokyo)       Date:  1981-09       Impact factor: 1.645

6.  Antitumor active glycosides from Condurango Cortex.

Authors:  K Hayashi; K Wada; H Mitsuhashi; H Bando; M Takase; S Terada; Y Koide; T Aiba; T Narita; D Mizuno
Journal:  Chem Pharm Bull (Tokyo)       Date:  1980-06       Impact factor: 1.645

7.  Condurango glycoside-rich components stimulate DNA damage-induced cell cycle arrest and ROS-mediated caspase-3 dependent apoptosis through inhibition of cell-proliferation in lung cancer, in vitro and in vivo.

Authors:  Sourav Sikdar; Avinaba Mukherjee; Samrat Ghosh; Anisur Rahman Khuda-Bukhsh
Journal:  Environ Toxicol Pharmacol       Date:  2013-12-15       Impact factor: 4.860

8.  Steroidal and pregnane glycosides from the rhizomes of Tacca chantrieri.

Authors:  Akihito Yokosuka; Yoshihiro Mimaki; Yutaka Sashida
Journal:  J Nat Prod       Date:  2002-09       Impact factor: 4.050
  8 in total
  2 in total

Review 1.  Poorly Investigated Ecuadorian Medicinal Plants.

Authors:  Chabaco Armijos; Jorge Ramírez; Giovanni Vidari
Journal:  Plants (Basel)       Date:  2022-06-16

2.  Five New Polyoxypregnane Glycosides from the Vines of Aspidopterysobcordata and Their Antinephrolithiasis Activity.

Authors:  Zhaocui Sun; Meiying Chen; Qinglong Li; Guoxu Ma; Haifeng Wu; Junshan Yang; Yihang Li; Xudong Xu
Journal:  Molecules       Date:  2022-07-19       Impact factor: 4.927
  2 in total

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