Literature DB >> 30250923

Starving PTEN-deficient prostate cancer cells thrive under nutrient stress by scavenging corpses for their supper.

Vaishali Jayashankar1, Brendan T Finicle1, Aimee L Edinger1.   

Abstract

Our recent work demonstrates that inactivating mutations in phosphatase and tensin homolog (PTEN) are sufficient to drive macropinocytosis in the context of AMP-activated protein kinase (AMPK) activation. Given that blocking macropinocytosis limits PTEN-deficient prostate tumor growth, AMPK or phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) inhibitors could have therapeutic value in castration-resistant prostate cancer patients, particularly when used in combination with standard of care therapies. Abbreviations: ATG5: autophagy related 5; NHE: Na(+)/H(+) exchanger; PAK1: p21-activated kinase 1; PI3K: phosphatidylinositol-4,5-bisphosphate 3-kinase; PIP3: phosphatidylinositol (3,4,5)-trisphosphate; PIP2: phosphatidylinositol (4,5)-bisphosphate; RAC1: Rac family small GTPase 1.

Entities:  

Keywords:  AMPK; PI3K pathway; PTEN; macropinocytosis; necrosis; nutrient scavenging; prostate cancer

Year:  2018        PMID： 30250923      PMCID： PMC6149707          DOI： 10.1080/23723556.2018.1472060

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Phase II trial of the PI3 kinase inhibitor buparlisib (BKM-120) with or without enzalutamide in men with metastatic castration resistant prostate cancer.

Authors:  Andrew J Armstrong; Susan Halabi; Patrick Healy; Joshi J Alumkal; Carolyn Winters; Julie Kephart; Rhonda L Bitting; Carey Hobbs; Colleen F Soleau; Tomasz M Beer; Rachel Slottke; Kelly Mundy; Evan Y Yu; Daniel J George
Journal:  Eur J Cancer       Date:  2017-05-11       Impact factor: 9.162

2.  PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells.

Authors:  Seong M Kim; Tricia T Nguyen; Archna Ravi; Peter Kubiniok; Brendan T Finicle; Vaishali Jayashankar; Leonel Malacrida; Jue Hou; Jane Robertson; Dong Gao; Jonathan Chernoff; Michelle A Digman; Eric O Potma; Bruce J Tromberg; Pierre Thibault; Aimee L Edinger
Journal:  Cancer Discov       Date:  2018-03-23       Impact factor: 39.397

Review 3.  A spatiotemporal hypothesis for the regulation, role, and targeting of AMPK in prostate cancer.

Authors:  Ayesha S Khan; Daniel E Frigo
Journal:  Nat Rev Urol       Date:  2017-02-01       Impact factor: 14.432

Review 4.  Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: an orally active anti-cancer drug waiting for its call-of-duty?

Authors:  Hayden Matthews; Marie Ranson; Michael J Kelso
Journal:  Int J Cancer       Date:  2011-08-01       Impact factor: 7.396

5.  Feedback suppression of PI3Kα signaling in PTEN-mutated tumors is relieved by selective inhibition of PI3Kβ.

Authors:  Sarit Schwartz; John Wongvipat; Cath B Trigwell; Urs Hancox; Brett S Carver; Vanessa Rodrik-Outmezguine; Marie Will; Paige Yellen; Elisa de Stanchina; José Baselga; Howard I Scher; Simon T Barry; Charles L Sawyers; Sarat Chandarlapaty; Neal Rosen
Journal:  Cancer Cell       Date:  2014-12-24       Impact factor: 31.743

6.  Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors.

Authors:  Shawn M Davidson; Oliver Jonas; Mark A Keibler; Han Wei Hou; Alba Luengo; Jared R Mayers; Jeffrey Wyckoff; Amanda M Del Rosario; Matthew Whitman; Christopher R Chin; Kendall J Condon; Alex Lammers; Katherine A Kellersberger; Brian K Stall; Gregory Stephanopoulos; Dafna Bar-Sagi; Jongyoon Han; Joshua D Rabinowitz; Michael J Cima; Robert Langer; Matthew G Vander Heiden
Journal:  Nat Med       Date:  2016-12-26       Impact factor: 53.440

Review 7.  Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation.

Authors:  Youhei Egami; Tomohiko Taguchi; Masashi Maekawa; Hiroyuki Arai; Nobukazu Araki
Journal:  Front Physiol       Date:  2014-09-30       Impact factor: 4.566

Review 8.  A review of the development of tumor vasculature and its effects on the tumor microenvironment.

Authors:  Jake C Forster; Wendy M Harriss-Phillips; Michael Jj Douglass; Eva Bezak
Journal:  Hypoxia (Auckl)       Date:  2017-04-11

9.  Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.

Authors:  Cosimo Commisso; Shawn M Davidson; Rengin G Soydaner-Azeloglu; Seth J Parker; Jurre J Kamphorst; Sean Hackett; Elda Grabocka; Michel Nofal; Jeffrey A Drebin; Craig B Thompson; Joshua D Rabinowitz; Christian M Metallo; Matthew G Vander Heiden; Dafna Bar-Sagi
Journal:  Nature       Date:  2013-05-12       Impact factor: 49.962

10.  Mechanisms of coagulative necrosis in malignant epithelial tumors (Review).

Authors:  Rosario A Caruso; Giovanni Branca; Francesco Fedele; Eleonora Irato; Giuseppe Finocchiaro; Antonio Parisi; Antonio Ieni
Journal:  Oncol Lett       Date:  2014-07-11       Impact factor: 2.967
  10 in total
  2 in total

Review 1.  Leveraging insights into cancer metabolism-a symposium report.

Authors:  Jennifer Cable; Lydia Finley; Benjamin P Tu; Gary J Patti; Trudy G Oliver; Santosha Vardhana; Miyeko Mana; Russell Ericksen; Sanika Khare; Ralph DeBerardinis; Brent R Stockwell; Aimee Edinger; Marcia Haigis; William Kaelin
Journal:  Ann N Y Acad Sci       Date:  2019-12-02       Impact factor: 5.691

Review 2.  Endocytosis in the context-dependent regulation of individual and collective cell properties.

Authors:  Sara Sigismund; Letizia Lanzetti; Giorgio Scita; Pier Paolo Di Fiore
Journal:  Nat Rev Mol Cell Biol       Date:  2021-06-01       Impact factor: 94.444
  2 in total

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