Literature DB >> 30250916

RIPK1-dependent mitophagy: A novel mechanism to eliminate cells detached from the extracellular matrix.

Mark A Hawk1, Zachary T Schafer1.   

Abstract

For cancer cells to survive during extracellular matrix (ECM)-detachment, they must inhibit anoikis and rectify metabolic deficiencies that lead to the induction of non-apoptotic cell death. Here, we highlight and discuss our recent study implicating receptor-interacting protein kinase-1 (RIPK1) in the induction of mitophagy, the production of reactive oxygen species (ROS) and the consequent elimination of ECM-detached cells.

Entities:  

Keywords:  RIPK1; cell death; mitophagy; reactive oxygen species; signal transduction

Year:  2018        PMID： 30250916      PMCID： PMC6149732          DOI： 10.1080/23723556.2018.1465015

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Metabolism during ECM Detachment: Achilles Heel of Cancer Cells?

Authors:  Joshua A Mason; Kimberly R Hagel; Mark A Hawk; Zachary T Schafer
Journal:  Trends Cancer       Date:  2017-05-23

2.  Oncogenic Ras differentially regulates metabolism and anoikis in extracellular matrix-detached cells.

Authors:  J A Mason; C A Davison-Versagli; A K Leliaert; D J Pape; C McCallister; J Zuo; S M Durbin; C L Buchheit; S Zhang; Z T Schafer
Journal:  Cell Death Differ       Date:  2016-02-26       Impact factor: 15.828

Review 3.  Regulated necrosis: the expanding network of non-apoptotic cell death pathways.

Authors:  Tom Vanden Berghe; Andreas Linkermann; Sandrine Jouan-Lanhouet; Henning Walczak; Peter Vandenabeele
Journal:  Nat Rev Mol Cell Biol       Date:  2014-02       Impact factor: 94.444

4.  The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways.

Authors:  Zhigao Wang; Hui Jiang; She Chen; Fenghe Du; Xiaodong Wang
Journal:  Cell       Date:  2012-01-20       Impact factor: 41.582

Review 5.  Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression.

Authors:  Cassandra L Buchheit; Kelsey J Weigel; Zachary T Schafer
Journal:  Nat Rev Cancer       Date:  2014-08-07       Impact factor: 60.716

6.  CAF-secreted IGFBPs regulate breast cancer cell anoikis.

Authors:  Kelsey J Weigel; Ana Jakimenko; Brooke A Conti; Sarah E Chapman; William J Kaliney; W Matthew Leevy; Matthew M Champion; Zachary T Schafer
Journal:  Mol Cancer Res       Date:  2014-05-06       Impact factor: 5.852

7.  Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment.

Authors:  Zachary T Schafer; Alexandra R Grassian; Loling Song; Zhenyang Jiang; Zachary Gerhart-Hines; Hanna Y Irie; Sizhen Gao; Pere Puigserver; Joan S Brugge
Journal:  Nature       Date:  2009-08-19       Impact factor: 49.962

8.  RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells.

Authors:  Mark A Hawk; Cassandra L Gorsuch; Patrick Fagan; Chan Lee; Sung Eun Kim; Jens C Hamann; Joshua A Mason; Kelsey J Weigel; Matyas Abel Tsegaye; Luqun Shen; Sydney Shuff; Junjun Zuo; Stephan Hu; Lei Jiang; Sarah Chapman; W Matthew Leevy; Ralph J DeBerardinis; Michael Overholtzer; Zachary T Schafer
Journal:  Nat Cell Biol       Date:  2018-02-19       Impact factor: 28.824

9.  Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson's-like movement disorder.

Authors:  Wei Lu; Senthilkumar S Karuppagounder; Danielle A Springer; Michele D Allen; Lixin Zheng; Brittany Chao; Yan Zhang; Valina L Dawson; Ted M Dawson; Michael Lenardo
Journal:  Nat Commun       Date:  2014-09-15       Impact factor: 14.919

10.  Reductive carboxylation supports redox homeostasis during anchorage-independent growth.

Authors:  Lei Jiang; Alexander A Shestov; Pamela Swain; Chendong Yang; Seth J Parker; Qiong A Wang; Lance S Terada; Nicholas D Adams; Michael T McCabe; Beth Pietrak; Stan Schmidt; Christian M Metallo; Brian P Dranka; Benjamin Schwartz; Ralph J DeBerardinis
Journal:  Nature       Date:  2016-04-06       Impact factor: 49.962
  10 in total

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