Literature DB >> 30250913

EnABLing Cathepsin-Driven Melanoma Metastasis.

Rakshamani Tripathi1, Rina Plattner1.   

Abstract

Metastatic melanoma remains incurable for many due to its aggressive nature. Secreted cathepsins promote metastasis by cleaving matrix and activating pro-invasive proteases. We reported that ABL kinases induce cathepsin secretion and subsequent metastasis by activating ETS1, SP1, and RELA pathways, indicating that ABL inhibitors may serve as novel anti-cathepsin agents.

Entities:  

Keywords:  ABL1; ABL2; Abl; Arg; ETS1; NF-κB; RELA; SP1; cathepsin; cysteine cathepsins

Year:  2018        PMID： 30250913      PMCID： PMC6149941          DOI： 10.1080/23723556.2018.1458016

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Cathepsin L targeting in cancer treatment.

Authors:  Dhivya R Sudhan; Dietmar W Siemann
Journal:  Pharmacol Ther       Date:  2015-08-20       Impact factor: 12.310

Review 2.  The role of the transcription factor Ets1 in carcinoma.

Authors:  Jürgen Dittmer
Journal:  Semin Cancer Biol       Date:  2015-09-25       Impact factor: 15.707

Review 3.  Sp1 transcription factor: A long-standing target in cancer chemotherapy.

Authors:  Carolina Vizcaíno; Sylvia Mansilla; José Portugal
Journal:  Pharmacol Ther       Date:  2015-05-08       Impact factor: 12.310

4.  Activation of abl family kinases in solid tumors.

Authors:  Sourik S Ganguly; Rina Plattner
Journal:  Genes Cancer       Date:  2012-05

5.  Nuclear factor-κB expression is predictive of overall survival in patients with cutaneous melanoma.

Authors:  Daniela Murtas; Franca Piras; Luigi Minerba; Jorge Ugalde; Michela Piga; Cristina Maxia; Maria Teresa Perra; Paola Sirigu
Journal:  Oncol Lett       Date:  2010-07-01       Impact factor: 2.967

Review 6.  Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response.

Authors:  Oakley C Olson; Johanna A Joyce
Journal:  Nat Rev Cancer       Date:  2015-12       Impact factor: 60.716

7.  Abl and Arg mediate cysteine cathepsin secretion to facilitate melanoma invasion and metastasis.

Authors:  Rakshamani Tripathi; Leann S Fiore; Dana L Richards; Yuchen Yang; Jinpeng Liu; Chi Wang; Rina Plattner
Journal:  Sci Signal       Date:  2018-02-20       Impact factor: 8.192

8.  c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion via distinct pathways, and drive metastatic progression.

Authors:  S S Ganguly; L S Fiore; J T Sims; J W Friend; D Srinivasan; M A Thacker; M L Cibull; C Wang; M Novak; D M Kaetzel; R Plattner
Journal:  Oncogene       Date:  2011-09-05       Impact factor: 9.867

9.  Abl kinase regulation by BRAF/ERK and cooperation with Akt in melanoma.

Authors:  A Jain; R Tripathi; C P Turpin; C Wang; R Plattner
Journal:  Oncogene       Date:  2017-04-03       Impact factor: 9.867

10.  c-Abl and Arg induce cathepsin-mediated lysosomal degradation of the NM23-H1 metastasis suppressor in invasive cancer.

Authors:  Leann S Fiore; Sourik S Ganguly; James Sledziona; Michael L Cibull; Chi Wang; Dana L Richards; Janna M Neltner; Carol Beach; Joseph R McCorkle; David M Kaetzel; Rina Plattner
Journal:  Oncogene       Date:  2013-10-07       Impact factor: 9.867
  10 in total

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