Literature DB >> 30250906

The decisive role of fumarase: Responsive signaling to glucose deficiency.

Qiujing Yu1, Ting Wang1, Yuhui Jiang1.   

Abstract

Our recent study shows that AMPK normally phosphorates fumarase (FH) at Ser75 under glucose deprivation, resulting in FH-ATF2 complex formation that facilitates transcription for cell growth arrest. Meanwhile, O-GlcNAc transferase can compete with AMPK to O-GlcNAcylate FH. In tumor cells, FH is highly O-GlcNAcylated and is proinhibited from AMPK-ATF2 signaling.

Entities:  

Keywords:  AMPK; O-GlcNAc transferase; fumarase; glucose deficiency

Year:  2018        PMID： 30250906      PMCID： PMC6150037          DOI： 10.1080/23723556.2017.1363848

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Synthesis of cell constituents from C2-units by a modified tricarboxylic acid cycle.

Authors:  H L KORNBERG; H A KREBS
Journal:  Nature       Date:  1957-05-18       Impact factor: 49.962

Review 2.  Histone methylation: a dynamic mark in health, disease and inheritance.

Authors:  Eric L Greer; Yang Shi
Journal:  Nat Rev Genet       Date:  2012-04-03       Impact factor: 53.242

3.  O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency.

Authors:  Ting Wang; Qiujing Yu; Jingjie Li; Bin Hu; Qin Zhao; Chunmin Ma; Wenhua Huang; Lingang Zhuo; Houqin Fang; Lujian Liao; Y Eugene Chin; Yuhui Jiang
Journal:  Nat Cell Biol       Date:  2017-06-19       Impact factor: 28.824

Review 4.  Nutrient regulation of gene expression by O-GlcNAcylation of chromatin.

Authors:  Stéphan Hardivillé; Gerald W Hart
Journal:  Curr Opin Chem Biol       Date:  2016-06-17       Impact factor: 8.822

Review 5.  Nutrient-sensing mechanisms and pathways.

Authors:  Alejo Efeyan; William C Comb; David M Sabatini
Journal:  Nature       Date:  2015-01-15       Impact factor: 49.962

Review 6.  How cancer metabolism is tuned for proliferation and vulnerable to disruption.

Authors:  Almut Schulze; Adrian L Harris
Journal:  Nature       Date:  2012-11-15       Impact factor: 49.962

Review 7.  O-GlcNAc transferase and O-GlcNAcase: achieving target substrate specificity.

Authors:  Alexis K Nagel; Lauren E Ball
Journal:  Amino Acids       Date:  2014-08-31       Impact factor: 3.520

8.  Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism.

Authors:  Rushika M Perera; Svetlana Stoykova; Brandon N Nicolay; Kenneth N Ross; Julien Fitamant; Myriam Boukhali; Justine Lengrand; Vikram Deshpande; Martin K Selig; Cristina R Ferrone; Jeff Settleman; Gregory Stephanopoulos; Nicholas J Dyson; Roberto Zoncu; Sridhar Ramaswamy; Wilhelm Haas; Nabeel Bardeesy
Journal:  Nature       Date:  2015-07-13       Impact factor: 49.962

9.  Sweet connections: O-GlcNAcylation links cancer cell metabolism and survival.

Authors:  Christina M Ferrer; Mauricio J Reginato
Journal:  Mol Cell Oncol       Date:  2014-10-29

10.  Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation.

Authors:  Yuhui Jiang; Xu Qian; Jianfeng Shen; Yugang Wang; Xinjian Li; Rui Liu; Yan Xia; Qianming Chen; Guang Peng; Shiaw-Yih Lin; Zhimin Lu
Journal:  Nat Cell Biol       Date:  2015-08-03       Impact factor: 28.213
  10 in total

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