Literature DB >> 30250899

EXD2: A new regulator of mitochondrial translation and potential target for cancer therapy.

Travis H Stracker1.   

Abstract

In recent work we identified Exonuclease 3'-5' domain-containing protein 2 (EXD2) as an RNase required for efficient mitochondrial translation. Here I describe in brief the cellular phenotypes caused by EXD2 deficiency and make the case that EXD2 inhibitors could be valuable agents for cancer therapy.

Entities:  

Keywords:  Biology of malignant cells; Cancer stem cells; EXD2; Mode of action of anticancer agents; Tumor metabolism; cancer metabolism; glutamine; metabolic reprogramming; metformin; mitochondria; translation

Year:  2018        PMID： 30250899      PMCID： PMC6149756          DOI： 10.1080/23723556.2018.1445943

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

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Review 4.  Targeting mitochondria metabolism for cancer therapy.

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6.  EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation.

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Journal:  Nat Cell Biol       Date:  2018-01-15       Impact factor: 28.824

7.  Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious disease.

Authors:  Rebecca Lamb; Bela Ozsvari; Camilla L Lisanti; Herbert B Tanowitz; Anthony Howell; Ubaldo E Martinez-Outschoorn; Federica Sotgia; Michael P Lisanti
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10.  EXD2 promotes homologous recombination by facilitating DNA end resection.

Authors:  Ronan Broderick; Jadwiga Nieminuszczy; Hannah T Baddock; Rajashree Deshpande; Opher Gileadi; Tanya T Paull; Peter J McHugh; Wojciech Niedzwiedz
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  10 in total

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