Literature DB >> 30250898

Autophagy-independent effects of autophagy-related-5 (Atg5) on exosome production and metastasis.

Huishan Guo1,2, Remy Sadoul3, Derrick Gibbings1,2.   

Abstract

Autophagy-related-5 (Atg5) and Autophagy-related-16-Like-1 (Atg16L1) canonically participate in autophagy. Recent research demonstrates that apart from this, they also control production of extracellular vesicles called exosomes by regulating acidification of late endosomes. Atg5-mediated exosome production increased migration and metastasis of breast cancer cells suggesting exosomes may perform some functions ascribed to autophagy.

Entities:  

Keywords:  V1V0-ATPase; acidification; autophagy; biology of malignant cells; exosomes; mechanisms of oncogenesis and tumor progression; metastasis

Year:  2018        PMID： 30250898      PMCID： PMC6149948          DOI： 10.1080/23723556.2018.1445941

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles.

Authors:  Marina Colombo; Graça Raposo; Clotilde Théry
Journal:  Annu Rev Cell Dev Biol       Date:  2014-08-21       Impact factor: 13.827

Review 2.  LC3/GABARAP family proteins: autophagy-(un)related functions.

Authors:  Marco B E Schaaf; Tom G Keulers; Marc A Vooijs; Kasper M A Rouschop
Journal:  FASEB J       Date:  2016-09-06       Impact factor: 5.191

3.  Atg5 Disassociates the V1V0-ATPase to Promote Exosome Production and Tumor Metastasis Independent of Canonical Macroautophagy.

Authors:  Huishan Guo; Maneka Chitiprolu; Luc Roncevic; Charlotte Javalet; Fiona J Hemming; My Tran Trung; Lingrui Meng; Elyse Latreille; Christiano Tanese de Souza; Danielle McCulloch; R Mitchell Baldwin; Rebecca Auer; Jocelyn Côté; Ryan Charles Russell; Rémy Sadoul; Derrick Gibbings
Journal:  Dev Cell       Date:  2017-12-18       Impact factor: 12.270

Review 4.  Mammalian Autophagy: How Does It Work?

Authors:  Carla F Bento; Maurizio Renna; Ghita Ghislat; Claudia Puri; Avraham Ashkenazi; Mariella Vicinanza; Fiona M Menzies; David C Rubinsztein
Journal:  Annu Rev Biochem       Date:  2016-02-08       Impact factor: 23.643

Review 5.  Autophagy and Tumor Metabolism.

Authors:  Alec C Kimmelman; Eileen White
Journal:  Cell Metab       Date:  2017-05-02       Impact factor: 27.287

Review 6.  Autophagy in malignant transformation and cancer progression.

Authors:  Lorenzo Galluzzi; Federico Pietrocola; José Manuel Bravo-San Pedro; Ravi K Amaravadi; Eric H Baehrecke; Francesco Cecconi; Patrice Codogno; Jayanta Debnath; David A Gewirtz; Vassiliki Karantza; Alec Kimmelman; Sharad Kumar; Beth Levine; Maria Chiara Maiuri; Seamus J Martin; Josef Penninger; Mauro Piacentini; David C Rubinsztein; Hans-Uwe Simon; Anne Simonsen; Andrew M Thorburn; Guillermo Velasco; Kevin M Ryan; Guido Kroemer
Journal:  EMBO J       Date:  2015-02-23       Impact factor: 11.598

Review 7.  Recent Insights into the Structure, Regulation, and Function of the V-ATPases.

Authors:  Kristina Cotter; Laura Stransky; Christina McGuire; Michael Forgac
Journal:  Trends Biochem Sci       Date:  2015-10       Impact factor: 13.807

Review 8.  Hidden behind autophagy: the unconventional roles of ATG proteins.

Authors:  Jovanka Bestebroer; Philip V'kovski; Mario Mauthe; Fulvio Reggiori
Journal:  Traffic       Date:  2013-07-30       Impact factor: 6.215

9.  Tumour exosome integrins determine organotropic metastasis.

Authors:  Ayuko Hoshino; Bruno Costa-Silva; Tang-Long Shen; Goncalo Rodrigues; Ayako Hashimoto; Milica Tesic Mark; Henrik Molina; Shinji Kohsaka; Angela Di Giannatale; Sophia Ceder; Swarnima Singh; Caitlin Williams; Nadine Soplop; Kunihiro Uryu; Lindsay Pharmer; Tari King; Linda Bojmar; Alexander E Davies; Yonathan Ararso; Tuo Zhang; Haiying Zhang; Jonathan Hernandez; Joshua M Weiss; Vanessa D Dumont-Cole; Kimberly Kramer; Leonard H Wexler; Aru Narendran; Gary K Schwartz; John H Healey; Per Sandstrom; Knut Jørgen Labori; Elin H Kure; Paul M Grandgenett; Michael A Hollingsworth; Maria de Sousa; Sukhwinder Kaur; Maneesh Jain; Kavita Mallya; Surinder K Batra; William R Jarnagin; Mary S Brady; Oystein Fodstad; Volkmar Muller; Klaus Pantel; Andy J Minn; Mina J Bissell; Benjamin A Garcia; Yibin Kang; Vinagolu K Rajasekhar; Cyrus M Ghajar; Irina Matei; Hector Peinado; Jacqueline Bromberg; David Lyden
Journal:  Nature       Date:  2015-10-28       Impact factor: 49.962

Review 10.  Autophagy in cancer metastasis.

Authors:  E E Mowers; M N Sharifi; K F Macleod
Journal:  Oncogene       Date:  2016-09-05       Impact factor: 9.867
  10 in total
  2 in total

1.  PPRV-Induced Autophagy Facilitates Infectious Virus Transmission by the Exosomal Pathway.

Authors:  Yangli Wan; Yan Chen; Ting Wang; Bao Zhao; Wei Zeng; Leyan Zhang; Yanming Zhang; Shengyan Cao; Jingyu Wang; Qinghong Xue; Xuefeng Qi
Journal:  J Virol       Date:  2022-03-23       Impact factor: 6.549

2.  The plasma peptides of breast versus ovarian cancer.

Authors:  Jaimie Dufresne; Pete Bowden; Thanusi Thavarajah; Angelique Florentinus-Mefailoski; Zhuo Zhen Chen; Monika Tucholska; Tenzin Norzin; Margaret Truc Ho; Morla Phan; Nargiz Mohamed; Amir Ravandi; Eric Stanton; Arthur S Slutsky; Claudia C Dos Santos; Alexander Romaschin; John C Marshall; Christina Addison; Shawn Malone; Daren Heyland; Philip Scheltens; Joep Killestein; Charlotte Teunissen; Eleftherios P Diamandis; K W M Siu; John G Marshall
Journal:  Clin Proteomics       Date:  2019-12-23       Impact factor: 3.988
  2 in total

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