Literature DB >> 30250894

The histone variant macroH2A1 is a splicing-modulated caretaker of genome integrity and tumor growth.

Jeongkyu Kim1, Philipp Oberdoerffer1, Simran Khurana2.   

Abstract

The macroH2A1.2 histone variant facilitates the response to replication stress with implications for genome maintenance and cell growth. A mutually exclusive splice variant, macroH2A1.1, has opposing effects on DNA repair outcome and proliferation. Here we discuss the potential impact of splicing-modulated macroH2A1 chromatin organization for cell function and malignant transformation.

Entities:  

Year:  2018        PMID： 30250894      PMCID： PMC6149989          DOI： 10.1080/23723556.2018.1441629

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Splicing regulates NAD metabolite binding to histone macroH2A.

Authors:  Georg Kustatscher; Michael Hothorn; Céline Pugieux; Klaus Scheffzek; Andreas G Ladurner
Journal:  Nat Struct Mol Biol       Date:  2005-06-19       Impact factor: 15.369

2.  FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16.

Authors:  Kyu Heo; Hyunjung Kim; Si Ho Choi; Jongkyu Choi; Kyunghwan Kim; Jiafeng Gu; Michael R Lieber; Allen S Yang; Woojin An
Journal:  Mol Cell       Date:  2008-04-11       Impact factor: 17.970

Review 3.  Variants of core histones and their roles in cell fate decisions, development and cancer.

Authors:  Marcus Buschbeck; Sandra B Hake
Journal:  Nat Rev Mol Cell Biol       Date:  2017-02-01       Impact factor: 94.444

4.  Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness.

Authors:  Etienne Dardenne; Sandra Pierredon; Keltouma Driouch; Lise Gratadou; Magali Lacroix-Triki; Micaela Polay Espinoza; Eleonora Zonta; Sophie Germann; Hussein Mortada; Jean-Philippe Villemin; Martin Dutertre; Rosette Lidereau; Stéphan Vagner; Didier Auboeuf
Journal:  Nat Struct Mol Biol       Date:  2012-09-30       Impact factor: 15.369

5.  QKI-mediated alternative splicing of the histone variant MacroH2A1 regulates cancer cell proliferation.

Authors:  Leonid Novikov; Jong Woo Park; Hongshan Chen; Hadassa Klerman; Abubakar S Jalloh; Matthew J Gamble
Journal:  Mol Cell Biol       Date:  2011-08-15       Impact factor: 4.272

6.  MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype.

Authors:  Hongshan Chen; Penelope D Ruiz; Wendy M McKimpson; Leonid Novikov; Richard N Kitsis; Matthew J Gamble
Journal:  Mol Cell       Date:  2015-08-20       Impact factor: 17.970

7.  A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation.

Authors:  Gyula Timinszky; Susanne Till; Paul O Hassa; Michael Hothorn; Georg Kustatscher; Bianca Nijmeijer; Julien Colombelli; Matthias Altmeyer; Ernst H K Stelzer; Klaus Scheffzek; Michael O Hottiger; Andreas G Ladurner
Journal:  Nat Struct Mol Biol       Date:  2009-08-13       Impact factor: 15.369

8.  Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions.

Authors:  Jeongkyu Kim; David Sturgill; Robin Sebastian; Simran Khurana; Andy D Tran; Garrett B Edwards; Alex Kruswick; Sandra Burkett; Eri K Hosogane; William W Hannon; Urbain Weyemi; William M Bonner; Karolin Luger; Philipp Oberdoerffer
Journal:  Mol Cell       Date:  2017-12-14       Impact factor: 17.970

Review 9.  Replication Stress: A Lifetime of Epigenetic Change.

Authors:  Simran Khurana; Philipp Oberdoerffer
Journal:  Genes (Basel)       Date:  2015-09-11       Impact factor: 4.096

10.  A macrohistone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance.

Authors:  Simran Khurana; Michael J Kruhlak; Jeongkyu Kim; Andy D Tran; Jinping Liu; Katherine Nyswaner; Lei Shi; Parthav Jailwala; Myong-Hee Sung; Ofir Hakim; Philipp Oberdoerffer
Journal:  Cell Rep       Date:  2014-08-14       Impact factor: 9.423
  10 in total
  8 in total

Review 1.  The Chromatin Landscape Channels DNA Double-Strand Breaks to Distinct Repair Pathways.

Authors:  Zulong Chen; Jessica K Tyler
Journal:  Front Cell Dev Biol       Date:  2022-06-08

2.  Histone Variant macroH2A1.1 Enhances Nonhomologous End Joining-dependent DNA Double-strand-break Repair and Reprogramming Efficiency of Human iPSCs.

Authors:  Sebastiano Giallongo; Daniela Řeháková; Tommaso Biagini; Oriana Lo Re; Priyanka Raina; Gabriela Lochmanová; Zbyněk Zdráhal; Igor Resnick; Pille Pata; Illar Pata; Martin Mistrík; João Pedro de Magalhães; Tommaso Mazza; Irena Koutná; Manlio Vinciguerra
Journal:  Stem Cells       Date:  2022-03-03       Impact factor: 5.845

3.  Poly(ADP-ribose) binding and macroH2A mediate recruitment and functions of KDM5A at DNA lesions.

Authors:  Ramhari Kumbhar; Anthony Sanchez; Jullian Perren; Fade Gong; David Corujo; Frank Medina; Sravan K Devanathan; Blerta Xhemalce; Andreas Matouschek; Marcus Buschbeck; Bethany A Buck-Koehntop; Kyle M Miller
Journal:  J Cell Biol       Date:  2021-05-18       Impact factor: 10.539

Review 4.  Histone H2A variants: Diversifying chromatin to ensure genome integrity.

Authors:  Philipp Oberdoerffer; Kyle M Miller
Journal:  Semin Cell Dev Biol       Date:  2022-03-21       Impact factor: 7.499

5.  The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening.

Authors:  Jeongkyu Kim; Chongkui Sun; Andy D Tran; Pei-Ju Chin; Penelope D Ruiz; Kun Wang; Richard J Gibbons; Matthew J Gamble; Yie Liu; Philipp Oberdoerffer
Journal:  Nat Struct Mol Biol       Date:  2019-03-04       Impact factor: 15.369

6.  Spatial and Functional Organization of Human Papillomavirus Replication Foci in the Productive Stage of Infection.

Authors:  Simran Khurana; Tovah E Markowitz; Juraj Kabat; Alison A McBride
Journal:  mBio       Date:  2021-11-09       Impact factor: 7.867

7.  The histone variant macroH2A1.1 regulates RNA polymerase II-paused genes within defined chromatin interaction landscapes.

Authors:  Ludmila Recoules; Alexandre Heurteau; Flavien Raynal; Nezih Karasu; Fatima Moutahir; Fabienne Bejjani; Isabelle Jariel-Encontre; Olivier Cuvier; Thomas Sexton; Anne-Claire Lavigne; Kerstin Bystricky
Journal:  J Cell Sci       Date:  2022-04-11       Impact factor: 5.235

8.  Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing.

Authors:  Lilas Courtot; Elodie Bournique; Chrystelle Maric; Laure Guitton-Sert; Miguel Madrid-Mencía; Vera Pancaldi; Jean-Charles Cadoret; Jean-Sébastien Hoffmann; Valérie Bergoglio
Journal:  Int J Mol Sci       Date:  2021-05-07       Impact factor: 5.923
  8 in total

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