Literature DB >> 30250886

Tumor-suppressive or tumor-supportive: For p53, that is the question.

Muhammad Riaz Khan1, Mian Wu1,2, Guangzhi Liu1.   

Abstract

We have recently reported a TP53 (known as p53) regulated long noncoding RNA named TRINGS (Tp53-regulated inhibitor of necrosis under glucose starvation). With the aid of TRINGS, p53 was shown to prevent cancer cells against necroptosis under glucose starvation. Our findings suggest that p53 may act as an oncogenic player in metabolic reprogramming.

Entities:  

Keywords:  glucose starvation; lncRNA; necroptosis; p53

Year:  2018        PMID： 30250886      PMCID： PMC6149755          DOI： 10.1080/23723556.2017.1408537

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

1.  NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration.

Authors:  Claudio Mauro; Shi Chi Leow; Elena Anso; Sonia Rocha; Anil K Thotakura; Laura Tornatore; Marta Moretti; Enrico De Smaele; Amer A Beg; Vinay Tergaonkar; Navdeep S Chandel; Guido Franzoso
Journal:  Nat Cell Biol       Date:  2011-08-28       Impact factor: 28.824

Review 2.  p53 in survival, death and metabolic health: a lifeguard with a licence to kill.

Authors:  Flore Kruiswijk; Christiaan F Labuschagne; Karen H Vousden
Journal:  Nat Rev Mol Cell Biol       Date:  2015-07       Impact factor: 94.444

3.  The p53-inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation.

Authors:  Muhammad Riaz Khan; Shaoxun Xiang; Zhiyin Song; Mian Wu
Journal:  EMBO J       Date:  2017-10-18       Impact factor: 11.598

4.  Role of STRAP in regulating GSK3β function and Notch3 stabilization.

Authors:  Nilesh D Kashikar; Wanguang Zhang; Pierre P Massion; Adriana L Gonzalez; Pran K Datta
Journal:  Cell Cycle       Date:  2011-05-15       Impact factor: 4.534

5.  MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma.

Authors:  Lei Jin; Wang Lai Hu; Chen Chen Jiang; Jia Xu Wang; Chuan Chun Han; Ping Chu; Lin Jie Zhang; Rick F Thorne; James Wilmott; Richard A Scolyer; Peter Hersey; Xu Dong Zhang; Mian Wu
Journal:  Proc Natl Acad Sci U S A       Date:  2011-09-06       Impact factor: 11.205

Review 6.  Shaping genetic alterations in human cancer: the p53 mutation paradigm.

Authors:  Thierry Soussi; Klas G Wiman
Journal:  Cancer Cell       Date:  2007-10       Impact factor: 31.743

7.  Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses.

Authors:  Connie Chao; Manfred Hergenhahn; Matthias D Kaeser; Zhiqun Wu; Shin'ichi Saito; Richard Iggo; Monica Hollstein; Ettore Appella; Yang Xu
Journal:  J Biol Chem       Date:  2003-08-08       Impact factor: 5.157

8.  Genome-wide analysis of the human p53 transcriptional network unveils a lncRNA tumour suppressor signature.

Authors:  Yolanda Sánchez; Victor Segura; Oskar Marín-Béjar; Alejandro Athie; Francesco P Marchese; Jovanna González; Luis Bujanda; Shuling Guo; Ander Matheu; Maite Huarte
Journal:  Nat Commun       Date:  2014-12-19       Impact factor: 14.919

9.  Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

Authors:  Oliver D K Maddocks; Celia R Berkers; Susan M Mason; Liang Zheng; Karen Blyth; Eyal Gottlieb; Karen H Vousden
Journal:  Nature       Date:  2012-12-16       Impact factor: 49.962
  9 in total
  3 in total

Review 1.  Progress in understanding the role of lncRNA in programmed cell death.

Authors:  Na Jiang; Xiaoyu Zhang; Xuejun Gu; Xiaozhuang Li; Lei Shang
Journal:  Cell Death Discov       Date:  2021-02-08

2.  Identification and validation of a novel necroptosis-related prognostic signature in cervical squamous cell carcinoma and endocervical adenocarcinoma.

Authors:  Weiyu Zhang; Wujun Cao; Zhuting Tong; Qinqin Jin; Xiya Jiang; Yinting Yang; Hui Yao; Guo Chen; Wei Gao; Yuting Zhu; Shuguang Zhou
Journal:  Front Oncol       Date:  2022-09-16       Impact factor: 5.738

3.  A novel necroptosis-related lncRNAs signature for survival prediction in clear cell renal cell carcinoma.

Authors:  Liwen Zhao; Huaijing Luo; Xingmo Dong; Zhihui Zeng; Jianlong Zhang; Yi Yi; Chaolu Lin
Journal:  Medicine (Baltimore)       Date:  2022-09-30       Impact factor: 1.817
  3 in total

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