Literature DB >> 30250882

Nutrient availability dictates the regulation of metabolism by the ribosomal protein-MDM2-p53 pathway.

Derek Franklin1,2,3, Yanping Zhang1,2,3,4.   

Abstract

Nutrient availability alters ribosomal biogenesis, causing ribosomal proteins to act as secondary messengers of nutrient response by binding to MDM2 and activating p53. Recent work suggests that the ribosomal protein (RP)-MDM2-p53 pathway responds to the deficiency or overabundance of nutrients through seemingly contradictory mechanisms; however, both of these responses promote organism survival.

Entities:  

Keywords:  High-fat diet; MDM2; lipid metabolism; nutrient availability; p53; ribosomal proteins

Year:  2017        PMID： 30250882      PMCID： PMC6150035          DOI： 10.1080/23723556.2017.1302904

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

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Authors:  J R Warner
Journal:  Trends Biochem Sci       Date:  1999-11       Impact factor: 13.807

Review 2.  The MDM2-p53 interaction.

Authors:  Ute M Moll; Oleksi Petrenko
Journal:  Mol Cancer Res       Date:  2003-12       Impact factor: 5.852

Review 3.  The origins and evolution of the p53 family of genes.

Authors:  Vladimir A Belyi; Prashanth Ak; Elke Markert; Haijian Wang; Wenwei Hu; Anna Puzio-Kuter; Arnold J Levine
Journal:  Cold Spring Harb Perspect Biol       Date:  2009-12-16       Impact factor: 10.005

4.  Cancer. p53, guardian of the genome.

Authors:  D P Lane
Journal:  Nature       Date:  1992-07-02       Impact factor: 49.962

5.  p53 dynamics control cell fate.

Authors:  Jeremy E Purvis; Kyle W Karhohs; Caroline Mock; Eric Batchelor; Alexander Loewer; Galit Lahav
Journal:  Science       Date:  2012-06-15       Impact factor: 47.728

6.  Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence.

Authors:  Tongyuan Li; Ning Kon; Le Jiang; Minjia Tan; Thomas Ludwig; Yingming Zhao; Richard Baer; Wei Gu
Journal:  Cell       Date:  2012-06-08       Impact factor: 41.582

7.  An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction.

Authors:  Everardo Macias; Aiwen Jin; Chad Deisenroth; Krishna Bhat; Hua Mao; Mikael S Lindström; Yanping Zhang
Journal:  Cancer Cell       Date:  2010-09-14       Impact factor: 31.743

Review 8.  The Evolution of the Ribosomal Protein-MDM2-p53 Pathway.

Authors:  Chad Deisenroth; Derek A Franklin; Yanping Zhang
Journal:  Cold Spring Harb Perspect Med       Date:  2016-12-01       Impact factor: 6.915

9.  Protection against High-Fat-Diet-Induced Obesity in MDM2C305F Mice Due to Reduced p53 Activity and Enhanced Energy Expenditure.

Authors:  Shijie Liu; Tae-Hyung Kim; Derek A Franklin; Yanping Zhang
Journal:  Cell Rep       Date:  2017-01-24       Impact factor: 9.423

10.  Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation.

Authors:  Yong Liu; Yizhou He; Aiwen Jin; Andrey P Tikunov; Lishi Zhou; Laura A Tollini; Patrick Leslie; Tae-Hyung Kim; Lei O Li; Rosalind A Coleman; Zhennan Gu; Yong Q Chen; Jeffrey M Macdonald; Lee M Graves; Yanping Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2014-05-28       Impact factor: 11.205
  10 in total

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