Literature DB >> 30250880

Aggressive leukemia driven by MLL-AF9.

Vaia Stavropoulou1, Antoine H F M Peters2,3, Juerg Schwaller1.   

Abstract

We recently showed that cellular origin impacts the aggressiveness and the phenotype of acute myeloid leukemia (AML). Direct induction of the MLL-AF9 fusion in various hematopoietic compartments in vivo using a doxycycline (DOX) regulated mouse model (iMLL-AF9) led to an invasive chemoresistant AML expressing several genes known to be involved in epithelial to mesenchymal transition (EMT) in solid cancers. Many of these genes play important roles in migration and invasion and are significantly associated with poor overall survival in AML patients.

Entities:  

Keywords:  AML; EMT; Evi1; LT-HSC; MLL-AF9

Year:  2017        PMID： 30250880      PMCID： PMC6149880          DOI： 10.1080/23723556.2016.1241854

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells.

Authors:  Ryo Yamamoto; Yohei Morita; Jun Ooehara; Sanae Hamanaka; Masafumi Onodera; Karl Lenhard Rudolph; Hideo Ema; Hiromitsu Nakauchi
Journal:  Cell       Date:  2013-08-29       Impact factor: 41.582

Review 2.  New insights into the regulation of epithelial-mesenchymal transition and tissue fibrosis.

Authors:  KangAe Lee; Celeste M Nelson
Journal:  Int Rev Cell Mol Biol       Date:  2012       Impact factor: 6.813

3.  Cell of origin determines clinically relevant subtypes of MLL-rearranged AML.

Authors:  A V Krivtsov; M E Figueroa; A U Sinha; M C Stubbs; Z Feng; P J M Valk; R Delwel; K Döhner; L Bullinger; A L Kung; A M Melnick; S A Armstrong
Journal:  Leukemia       Date:  2012-12-13       Impact factor: 11.528

4.  Hematopoietic stem cells are intrinsically protected against MLL-ENL-mediated transformation.

Authors:  Amol Ugale; Gudmundur L Norddahl; Martin Wahlestedt; Petter Säwén; Pekka Jaako; Cornelis Jan Pronk; Shamit Soneji; Jörg Cammenga; David Bryder
Journal:  Cell Rep       Date:  2014-11-13       Impact factor: 9.423

5.  EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs.

Authors:  Eric M J Bindels; Marije Havermans; Sanne Lugthart; Claudia Erpelinck; Elizabeth Wocjtowicz; Andrei V Krivtsov; Elwin Rombouts; Scott A Armstrong; Erdogan Taskesen; Jurgen R Haanstra; H Berna Beverloo; Hartmut Döhner; Wendy A Hudson; John H Kersey; Ruud Delwel; Ashish R Kumar
Journal:  Blood       Date:  2012-05-02       Impact factor: 22.113

Review 6.  Cells of origin in cancer.

Authors:  Jane E Visvader
Journal:  Nature       Date:  2011-01-20       Impact factor: 49.962

7.  MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome.

Authors:  Vaia Stavropoulou; Susanne Kaspar; Laurent Brault; Mathijs A Sanders; Sabine Juge; Stefano Morettini; Alexandar Tzankov; Michelina Iacovino; I-Jun Lau; Thomas A Milne; Hélène Royo; Michael Kyba; Peter J M Valk; Antoine H F M Peters; Juerg Schwaller
Journal:  Cancer Cell       Date:  2016-06-23       Impact factor: 31.743

8.  The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias.

Authors:  Anna K Andersson; Jing Ma; Jianmin Wang; Xiang Chen; Amanda Larson Gedman; Jinjun Dang; Joy Nakitandwe; Linda Holmfeldt; Matthew Parker; John Easton; Robert Huether; Richard Kriwacki; Michael Rusch; Gang Wu; Yongjin Li; Heather Mulder; Susana Raimondi; Stanley Pounds; Guolian Kang; Lei Shi; Jared Becksfort; Pankaj Gupta; Debbie Payne-Turner; Bhavin Vadodaria; Kristy Boggs; Donald Yergeau; Jayanthi Manne; Guangchun Song; Michael Edmonson; Panduka Nagahawatte; Lei Wei; Cheng Cheng; Deqing Pei; Rosemary Sutton; Nicola C Venn; Albert Chetcuti; Amanda Rush; Daniel Catchpoole; Jesper Heldrup; Thoas Fioretos; Charles Lu; Li Ding; Ching-Hon Pui; Sheila Shurtleff; Charles G Mullighan; Elaine R Mardis; Richard K Wilson; Tanja A Gruber; Jinghui Zhang; James R Downing
Journal:  Nat Genet       Date:  2015-03-02       Impact factor: 38.330

9.  Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells.

Authors:  Joshy George; Asli Uyar; Kira Young; Lauren Kuffler; Kaiden Waldron-Francis; Eladio Marquez; Duygu Ucar; Jennifer J Trowbridge
Journal:  Nat Commun       Date:  2016-07-11       Impact factor: 14.919

10.  Mitotic History Reveals Distinct Stem Cell Populations and Their Contributions to Hematopoiesis.

Authors:  Petter Säwén; Stefan Lang; Pankaj Mandal; Derrick J Rossi; Shamit Soneji; David Bryder
Journal:  Cell Rep       Date:  2016-03-17       Impact factor: 9.423
  10 in total
  4 in total

1.  Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1.

Authors:  Xiaomin Ni; David Heidenreich; Thomas Christott; James Bennett; Moses Moustakim; Paul E Brennan; Oleg Fedorov; Stefan Knapp; Apirat Chaikuad
Journal:  ACS Med Chem Lett       Date:  2019-11-25       Impact factor: 4.345

2.  P2X7 promotes the progression of MLL-AF9 induced acute myeloid leukemia by upregulation of Pbx3.

Authors:  Wenli Feng; Xiao Yang; Lina Wang; Rong Wang; Feifei Yang; Hao Wang; Xiaoli Liu; Qian Ren; Yingchi Zhang; Xiaofan Zhu; Guoguang Zheng
Journal:  Haematologica       Date:  2021-05-01       Impact factor: 9.941

Review 3.  High-Throughput CRISPR Screening in Hematological Neoplasms.

Authors:  Raquel Ancos-Pintado; Irene Bragado-García; María Luz Morales; Roberto García-Vicente; Andrés Arroyo-Barea; Alba Rodríguez-García; Joaquín Martínez-López; María Linares; María Hernández-Sánchez
Journal:  Cancers (Basel)       Date:  2022-07-25       Impact factor: 6.575

Review 4.  Insights on the Interplay between Cells Metabolism and Signaling: A Therapeutic Perspective in Pediatric Acute Leukemias.

Authors:  Laura Anselmi; Salvatore Nicola Bertuccio; Annalisa Lonetti; Arcangelo Prete; Riccardo Masetti; Andrea Pession
Journal:  Int J Mol Sci       Date:  2020-08-28       Impact factor: 5.923
  4 in total

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