Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The Cohesion complex maintains genome stability by preventing end joining of distant DNA ends in S phase.

Literature DB >> 30250878

The Cohesion complex maintains genome stability by preventing end joining of distant DNA ends in S phase.

Camille Gelot¹, Josée Guirouilh-Barbat¹, Bernard S Lopez¹.

Abstract

Genome instability is a hallmark of cancer cells. The joining of distant DNA double-strand ends (DSEs) ineluctably leads to genome rearrangements. We found that the cohesion complex maintains genome stability by repressing the joining of distant DSEs specifically in the S phase, i.e., the main phase producing one-ended DSEs.

Entities: Chemical Disease

Keywords: Cohesin; NHEJ; double-strand break repair; genome rearrangements; replication stress

Year: 2018 PMID： 30250878 PMCID： PMC6149804 DOI： 10.1080/23723556.2016.1154123

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

10 in total

1. The Cohesin Complex Prevents the End Joining of Distant DNA Double-Strand Ends.

Authors: Camille Gelot; Josée Guirouilh-Barbat; Tangui Le Guen; Elodie Dardillac; Catherine Chailleux; Yvan Canitrot; Bernard S Lopez
Journal: Mol Cell Date: 2015-12-10 Impact factor: 17.970

2. Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.

Authors: Ayana Kon; Lee-Yung Shih; Masashi Minamino; Masashi Sanada; Yuichi Shiraishi; Yasunobu Nagata; Kenichi Yoshida; Yusuke Okuno; Masashige Bando; Ryuichiro Nakato; Shumpei Ishikawa; Aiko Sato-Otsubo; Genta Nagae; Aiko Nishimoto; Claudia Haferlach; Daniel Nowak; Yusuke Sato; Tamara Alpermann; Masao Nagasaki; Teppei Shimamura; Hiroko Tanaka; Kenichi Chiba; Ryo Yamamoto; Tomoyuki Yamaguchi; Makoto Otsu; Naoshi Obara; Mamiko Sakata-Yanagimoto; Tsuyoshi Nakamaki; Ken Ishiyama; Florian Nolte; Wolf-Karsten Hofmann; Shuichi Miyawaki; Shigeru Chiba; Hiraku Mori; Hiromitsu Nakauchi; H Phillip Koeffler; Hiroyuki Aburatani; Torsten Haferlach; Katsuhiko Shirahige; Satoru Miyano; Seishi Ogawa
Journal: Nat Genet Date: 2013-08-18 Impact factor: 38.330

3. CTCF/cohesin-binding sites are frequently mutated in cancer.

Authors: Riku Katainen; Kashyap Dave; Esa Pitkänen; Kimmo Palin; Teemu Kivioja; Niko Välimäki; Alexandra E Gylfe; Heikki Ristolainen; Ulrika A Hänninen; Tatiana Cajuso; Johanna Kondelin; Tomas Tanskanen; Jukka-Pekka Mecklin; Heikki Järvinen; Laura Renkonen-Sinisalo; Anna Lepistö; Eevi Kaasinen; Outi Kilpivaara; Sari Tuupanen; Martin Enge; Jussi Taipale; Lauri A Aaltonen
Journal: Nat Genet Date: 2015-06-08 Impact factor: 38.330

4. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions.

Authors: Vassilis G Gorgoulis; Leandros-Vassilios F Vassiliou; Panagiotis Karakaidos; Panayotis Zacharatos; Athanassios Kotsinas; Triantafillos Liloglou; Monica Venere; Richard A Ditullio; Nikolaos G Kastrinakis; Brynn Levy; Dimitris Kletsas; Akihiro Yoneta; Meenhard Herlyn; Christos Kittas; Thanos D Halazonetis
Journal: Nature Date: 2005-04-14 Impact factor: 49.962

5. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis.

Authors: Jirina Bartkova; Zuzana Horejsí; Karen Koed; Alwin Krämer; Frederic Tort; Karsten Zieger; Per Guldberg; Maxwell Sehested; Jahn M Nesland; Claudia Lukas; Torben Ørntoft; Jiri Lukas; Jiri Bartek
Journal: Nature Date: 2005-04-14 Impact factor: 49.962

6. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.

Authors: Jirina Bartkova; Nousin Rezaei; Michalis Liontos; Panagiotis Karakaidos; Dimitris Kletsas; Natalia Issaeva; Leandros-Vassilios F Vassiliou; Evangelos Kolettas; Katerina Niforou; Vassilis C Zoumpourlis; Munenori Takaoka; Hiroshi Nakagawa; Frederic Tort; Kasper Fugger; Fredrik Johansson; Maxwell Sehested; Claus L Andersen; Lars Dyrskjot; Torben Ørntoft; Jiri Lukas; Christos Kittas; Thomas Helleday; Thanos D Halazonetis; Jiri Bartek; Vassilis G Gorgoulis
Journal: Nature Date: 2006-11-30 Impact factor: 49.962

1 in total

Review 1. Replication Stress, DNA Damage, Inflammatory Cytokines and Innate Immune Response.

Authors: Sandrine Ragu; Gabriel Matos-Rodrigues; Bernard S Lopez
Journal: Genes (Basel) Date: 2020-04-09 Impact factor: 4.096

1 in total

The Cohesion complex maintains genome stability by preventing end joining of distant DNA ends in S phase.

1. The Cohesin Complex Prevents the End Joining of Distant DNA Double-Strand Ends.

2. Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.

3. CTCF/cohesin-binding sites are frequently mutated in cancer.

4. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions.

5. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis.

6. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.

Review 7. The ancient and evolving roles of cohesin in gene expression and DNA repair.

8. Deregulation of RAD21 and RUNX1 expression in endometrial cancer.

Review 9. Replication stress in Mammalian cells and its consequences for mitosis.

Review 10. Is non-homologous end-joining really an inherently error-prone process?

Review 1. Replication Stress, DNA Damage, Inflammatory Cytokines and Innate Immune Response.