Literature DB >> 30250877

Linking SLAMF1 to autophagy and sensitivity to therapy in chronic lymphocytic leukemia.

Cinzia Bologna1,2, Silvia Deaglio1,2.   

Abstract

We recently reported that expression of the costimulatory molecule and microbial sensor SLAMF1 (signaling lymphocytic activation molecule family 1, also known as CD150) is lost in chronic lymphocytic leukemia (CLL) patients characterized by a shorter overall survival. SLAMF1 modulates CLL responses to chemokines and regulates autophagy. Loss of SLAMF1 renders CLL cells relatively unresponsive to autophagy-inducing drugs, including B-cell CLL/lymphoma 2 (BCL2) inhibitors.

Entities:  

Keywords:  Autophagy; CLL; SLAMF1

Year:  2018        PMID： 30250877      PMCID： PMC6149729          DOI： 10.1080/23723556.2016.1143077

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol.

Authors:  Emilia Mahoney; David M Lucas; Sneha V Gupta; Amy J Wagner; Sarah E M Herman; Lisa L Smith; Yuh-Ying Yeh; Leslie Andritsos; Jeffrey A Jones; Joseph M Flynn; Kristie A Blum; Xiaoli Zhang; Amy Lehman; Hui Kong; Metin Gurcan; Michael R Grever; Amy J Johnson; John C Byrd
Journal:  Blood       Date:  2012-06-27       Impact factor: 22.113

Review 2.  Chronic lymphocytic leukemia.

Authors:  Nicholas Chiorazzi; Kanti R Rai; Manlio Ferrarini
Journal:  N Engl J Med       Date:  2005-02-24       Impact factor: 91.245

3.  CD38 increases CXCL12-mediated signals and homing of chronic lymphocytic leukemia cells.

Authors:  T Vaisitti; S Aydin; D Rossi; F Cottino; L Bergui; G D'Arena; L Bonello; A L Horenstein; P Brennan; C Pepper; G Gaidano; F Malavasi; S Deaglio
Journal:  Leukemia       Date:  2010-03-11       Impact factor: 11.528

Review 4.  Molecular pathogenesis of chronic lymphocytic leukemia.

Authors:  Gianluca Gaidano; Robin Foà; Riccardo Dalla-Favera
Journal:  J Clin Invest       Date:  2012-10-01       Impact factor: 14.808

5.  SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages.

Authors:  Scott B Berger; Xavier Romero; Chunyan Ma; Guoxing Wang; William A Faubion; Gongxian Liao; Ewoud Compeer; Marton Keszei; Lucia Rameh; Ninghai Wang; Marianne Boes; Jose R Regueiro; Hans-Christian Reinecker; Cox Terhorst
Journal:  Nat Immunol       Date:  2010-09-05       Impact factor: 25.606

6.  An inhibitor of Bcl-2 family proteins induces regression of solid tumours.

Authors:  Tilman Oltersdorf; Steven W Elmore; Alexander R Shoemaker; Robert C Armstrong; David J Augeri; Barbara A Belli; Milan Bruncko; Thomas L Deckwerth; Jurgen Dinges; Philip J Hajduk; Mary K Joseph; Shinichi Kitada; Stanley J Korsmeyer; Aaron R Kunzer; Anthony Letai; Chi Li; Michael J Mitten; David G Nettesheim; ShiChung Ng; Paul M Nimmer; Jacqueline M O'Connor; Anatol Oleksijew; Andrew M Petros; John C Reed; Wang Shen; Stephen K Tahir; Craig B Thompson; Kevin J Tomaselli; Baole Wang; Michael D Wendt; Haichao Zhang; Stephen W Fesik; Saul H Rosenberg
Journal:  Nature       Date:  2005-05-15       Impact factor: 49.962

Review 7.  Autophagy in malignant transformation and cancer progression.

Authors:  Lorenzo Galluzzi; Federico Pietrocola; José Manuel Bravo-San Pedro; Ravi K Amaravadi; Eric H Baehrecke; Francesco Cecconi; Patrice Codogno; Jayanta Debnath; David A Gewirtz; Vassiliki Karantza; Alec Kimmelman; Sharad Kumar; Beth Levine; Maria Chiara Maiuri; Seamus J Martin; Josef Penninger; Mauro Piacentini; David C Rubinsztein; Hans-Uwe Simon; Anne Simonsen; Andrew M Thorburn; Guillermo Velasco; Kevin M Ryan; Guido Kroemer
Journal:  EMBO J       Date:  2015-02-23       Impact factor: 11.598

8.  SLAMF1 regulation of chemotaxis and autophagy determines CLL patient response.

Authors:  Cinzia Bologna; Roberta Buonincontri; Sara Serra; Tiziana Vaisitti; Valentina Audrito; Davide Brusa; Andrea Pagnani; Marta Coscia; Giovanni D'Arena; Elisabetta Mereu; Roberto Piva; Richard R Furman; Davide Rossi; Gianluca Gaidano; Cox Terhorst; Silvia Deaglio
Journal:  J Clin Invest       Date:  2015-11-30       Impact factor: 14.808

Review 9.  The SLAM and SAP gene families control innate and adaptive immune responses.

Authors:  Silvia Calpe; Ninghai Wang; Xavier Romero; Scott B Berger; Arpad Lanyi; Pablo Engel; Cox Terhorst
Journal:  Adv Immunol       Date:  2008       Impact factor: 3.543

Review 10.  Autophagy and the integrated stress response.

Authors:  Guido Kroemer; Guillermo Mariño; Beth Levine
Journal:  Mol Cell       Date:  2010-10-22       Impact factor: 17.970
  10 in total
  1 in total

1.  Human M1 macrophages express unique innate immune response genes after mycobacterial infection to defend against tuberculosis.

Authors:  Arshad Khan; Kangling Zhang; Vipul K Singh; Abhishek Mishra; Priyanka Kachroo; Tian Bing; Jong Hak Won; Arunmani Mani; Ramesha Papanna; Lovepreet K Mann; Eder Ledezma-Campos; Genesis Aguillon-Duran; David H Canaday; Sunil A David; Blanca I Restrepo; Nhung Nguyen Viet; Ha Phan; Edward A Graviss; James M Musser; Deepak Kaushal; Marie Claire Gauduin; Chinnaswamy Jagannath
Journal:  Commun Biol       Date:  2022-05-19
  1 in total

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