Literature DB >> 30250876

Crosstalk between p53 modifiers at PML bodies.

Sonja Matt1, Thomas G Hofmann1.   

Abstract

Tumor protein p53 (TP53, best known as p53), the most frequently mutated tumor suppressor in cancer, plays a central role in cell fate decisions induced by DNA damage. Regulation of p53 activity by post-translational modifications has been linked to promyelocytic leukemia nuclear bodies (PML-NBs), where p53 encounters many of its regulators. Recent evidence implies that crosstalk between p53 regulators at the PML-NB shapes post-translational modifications and function of p53.

Entities:  

Keywords:  DNA damage; HIPK2; PML; SIRT1; apoptosis; crosstalk; nuclear body; p53

Year:  2018        PMID： 30250876      PMCID： PMC6150047          DOI： 10.1080/23723556.2015.1074335

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Blinded by the Light: The Growing Complexity of p53.

Authors:  Karen H Vousden; Carol Prives
Journal:  Cell       Date:  2009-05-01       Impact factor: 41.582

2.  Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.

Authors:  Melanie Winter; Dirk Sombroek; Ilka Dauth; Jutta Moehlenbrink; Karin Scheuermann; Johanna Crone; Thomas G Hofmann
Journal:  Nat Cell Biol       Date:  2008-06-08       Impact factor: 28.824

3.  Acetylation is indispensable for p53 activation.

Authors:  Yi Tang; Wenhui Zhao; Yue Chen; Yingming Zhao; Wei Gu
Journal:  Cell       Date:  2008-05-16       Impact factor: 41.582

Review 4.  PML nuclear bodies: regulation, function and therapeutic perspectives.

Authors:  Umut Sahin; Valérie Lallemand-Breitenbach; Hugues de Thé
Journal:  J Pathol       Date:  2014-11       Impact factor: 7.996

5.  Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.

Authors:  Emma Langley; Mark Pearson; Mario Faretta; Uta-Maria Bauer; Roy A Frye; Saverio Minucci; Pier Giuseppe Pelicci; Tony Kouzarides
Journal:  EMBO J       Date:  2002-05-15       Impact factor: 11.598

6.  Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2.

Authors:  Thomas G Hofmann; Andreas Möller; Hüaeyin Sirma; Hanswalter Zentgraf; Yoichi Taya; Wulf Dröge; Hans Will; M Lienhard Schmitz
Journal:  Nat Cell Biol       Date:  2002-01       Impact factor: 28.824

7.  p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53.

Authors:  K Oda; H Arakawa; T Tanaka; K Matsuda; C Tanikawa; T Mori; H Nishimori; K Tamai; T Tokino; Y Nakamura; Y Taya
Journal:  Cell       Date:  2000-09-15       Impact factor: 41.582

Review 8.  Role of nuclear bodies in apoptosis signalling.

Authors:  Eva Krieghoff-Henning; Thomas G Hofmann
Journal:  Biochim Biophys Acta       Date:  2008-07-16

9.  Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity.

Authors:  Eun-Joo Kim; Jeong-Hoon Kho; Moo-Rim Kang; Soo-Jong Um
Journal:  Mol Cell       Date:  2007-10-26       Impact factor: 17.970

10.  HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism.

Authors:  E Conrad; T Polonio-Vallon; M Meister; S Matt; N Bitomsky; C Herbel; M Liebl; V Greiner; B Kriznik; S Schumacher; E Krieghoff-Henning; T G Hofmann
Journal:  Cell Death Differ       Date:  2015-06-26       Impact factor: 15.828
  10 in total
  5 in total

Review 1.  The Role of ND10 Nuclear Bodies in Herpesvirus Infection: A Frenemy for the Virus?

Authors:  Behdokht Jan Fada; Eleazar Reward; Haidong Gu
Journal:  Viruses       Date:  2021-02-03       Impact factor: 5.048

Review 2.  Regulating the p53 Tumor Suppressor Network at PML Biomolecular Condensates.

Authors:  Magdalena C Liebl; Thomas G Hofmann
Journal:  Cancers (Basel)       Date:  2022-09-20       Impact factor: 6.575

Review 3.  The Interplay Between the Genetic and Immune Landscapes of AML: Mechanisms and Implications for Risk Stratification and Therapy.

Authors:  Lourdes M Mendez; Ryan R Posey; Pier Paolo Pandolfi
Journal:  Front Oncol       Date:  2019-11-07       Impact factor: 6.244

Review 4.  Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene.

Authors:  Alessandro Liquori; Mariam Ibañez; Claudia Sargas; Miguel Ángel Sanz; Eva Barragán; José Cervera
Journal:  Cancers (Basel)       Date:  2020-03-08       Impact factor: 6.639

5.  TRAIL-receptor 2-a novel negative regulator of p53.

Authors:  Anna Willms; Hella Schupp; Michelle Poelker; Alshaimaa Adawy; Jan Frederik Debus; Torsten Hartwig; Tim Krichel; Jürgen Fritsch; Steven Singh; Henning Walczak; Silvia von Karstedt; Heiner Schäfer; Anna Trauzold
Journal:  Cell Death Dis       Date:  2021-07-31       Impact factor: 8.469
  5 in total

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