Literature DB >> 30250875

The roles of NANOG in tumorigenesis.

Jinchul Kim1,2, Stefan Yu2, Yang Xu1,2.   

Abstract

The pluripotency factor Nanog is highly expressed in pluripotent stem cells and certain adult stem cells, but is not expressed in normal adult cells. However, Nanog is frequently overexpressed in human cancers. Here, we discuss the distinct oncogenic roles of Nanog at various stages of tumorigenesis.

Entities:  

Keywords:  Differentiation; Nanog; p53; tumorigenesis

Year:  2015        PMID： 30250875      PMCID： PMC6149947          DOI： 10.1080/23723556.2015.1074334

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17.

Authors:  Juan Guinea-Viniegra; Rainer Zenz; Harald Scheuch; María Jiménez; Latifa Bakiri; Peter Petzelbauer; Erwin F Wagner
Journal:  J Clin Invest       Date:  2012-07-09       Impact factor: 14.808

2.  Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma.

Authors:  Juanjuan Shan; Junjie Shen; Limei Liu; Feng Xia; Chuan Xu; Guangjie Duan; Yanmin Xu; Qinghua Ma; Zhi Yang; Qianzhen Zhang; Leina Ma; Jia Liu; Senlin Xu; Xiaochu Yan; Ping Bie; Youhong Cui; Xiu-wu Bian; Cheng Qian
Journal:  Hepatology       Date:  2012-07-12       Impact factor: 17.425

3.  Pluripotency factor Nanog is tumorigenic by deregulating DNA damage response in somatic cells.

Authors:  J Kim; Y Liu; M Qiu; Y Xu
Journal:  Oncogene       Date:  2015-06-15       Impact factor: 9.867

4.  Nanog signaling in cancer promotes stem-like phenotype and immune evasion.

Authors:  Kyung Hee Noh; Bo Wook Kim; Kwon-Ho Song; Hanbyoul Cho; Young-Ho Lee; Jin Hee Kim; Joon-Yong Chung; Jae-Hoon Kim; Stephen M Hewitt; Seung-Yong Seong; Chih-Ping Mao; T-C Wu; Tae Woo Kim
Journal:  J Clin Invest       Date:  2012-10-24       Impact factor: 14.808

5.  Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications.

Authors:  Erika L Abel; Joe M Angel; Kaoru Kiguchi; John DiGiovanni
Journal:  Nat Protoc       Date:  2009-08-27       Impact factor: 13.491

6.  The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis.

Authors:  X Lu; S J Mazur; T Lin; E Appella; Y Xu
Journal:  Oncogene       Date:  2013-06-17       Impact factor: 9.867

7.  Nanog induces hyperplasia without initiating tumors.

Authors:  Gerrit Fischedick; Guangming Wu; Kenjiro Adachi; Marcos J Araúzo-Bravo; Boris Greber; Martina Radstaak; Gabriele Köhler; Natalia Tapia; Roberto Iacone; Konstantinos Anastassiadis; Hans R Schöler; Holm Zaehres
Journal:  Stem Cell Res       Date:  2014-08-10       Impact factor: 2.020

8.  The pluripotency factor NANOG promotes the formation of squamous cell carcinomas.

Authors:  Adelaida R Palla; Daniela Piazzolla; Noelia Alcazar; Marta Cañamero; Osvaldo Graña; Gonzalo Gómez-López; Orlando Dominguez; Marta Dueñas; Jesús M Paramio; Manuel Serrano
Journal:  Sci Rep       Date:  2015-05-19       Impact factor: 4.379

9.  In vivo functional studies of tumor-specific retrogene NanogP8 in transgenic animals.

Authors:  Mark A Badeaux; Collene R Jeter; Shuai Gong; Bigang Liu; Mahipal V Suraneni; Joyce Rundhaug; Susan M Fischer; Tao Yang; Donna Kusewitt; Dean G Tang
Journal:  Cell Cycle       Date:  2013-06-26       Impact factor: 4.534

10.  A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A.

Authors:  Xin Zhang; Irina Neganova; Stefan Przyborski; Chunbo Yang; Michael Cooke; Stuart P Atkinson; George Anyfantis; Stefan Fenyk; W Nicol Keith; Stacey F Hoare; Owen Hughes; Tom Strachan; Miodrag Stojkovic; Philip W Hinds; Lyle Armstrong; Majlinda Lako
Journal:  J Cell Biol       Date:  2009-01-12       Impact factor: 10.539
  10 in total

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