Cheng-Chieh Lin6,7, Kuo-Tung Tang3, Chia-Ing Li4,2, Chiu-Shong Liu1,2, Ming-May Lai1,2, Wen-Yuan Lin1,2,5, Cheng-Chieh Lin6,7. 1. Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan. 2. Department of Family Medicine, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan. 3. Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan. 4. Medical Research, China Medical University Hospital, Taichung, Taiwan. 5. Social Medicine, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan. 6. Department of Family Medicine, China Medical University Hospital, Taichung, Taiwancclin@mail.cmuh.org.tw. 7. Department of Family Medicine, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwancclin@mail.cmuh.org.tw.
Abstract
BACKGROUND/AIMS: Brachial-ankle pulse wave velocity (baPWV) reflects the stiffness of muscular arteries. Albuminuria is recognized as a marker of vascular dysfunction. We assessed the association between arterial stiffness and albuminuria in a population-based longitudinal study. METHODS: 1116 adults aged ≥ 40 years in the Taichung Community Health Study (TCHS) in 2004 attended a follow-up visit in 2011. Albuminuria was defined as an urinary albumin-to-creatinine ratio (UACR) ≥ 30 mg/g. Arterial stiffness was defined as BaPWV ≥ 1540 cm/sec in males and BaPWV ≥ 1480 cm/sec in females, respectively. ∆baPWV was calculated as baPWV at follow-up minus baPWV at baseline, while ∆UACR was calculated as UACR at follow-up minus UACR at baseline. Multiple linear and logistic regression analyses were used to explore the relationship between albuminuria and arterial stiffness. RESULTS: Among 652 subjects without arterial stiffness at baseline, 209 (32%) subjects developed incident arterial stiffness after an average of 6.6 years. In male subjects, baseline albuminuria was associated with development of arterial stiffness (odds ratio: 4.47, 95% confidence interval [CI]: 1.04-19.31) and ∆baPWV was modestly positively associated with ∆UACR. CONCLUSION: Our results indicated that male adults with albuminuria had an increased risk for developing arterial stiffness.
BACKGROUND/AIMS: Brachial-ankle pulse wave velocity (baPWV) reflects the stiffness of muscular arteries. Albuminuria is recognized as a marker of vascular dysfunction. We assessed the association between arterial stiffness and albuminuria in a population-based longitudinal study. METHODS: 1116 adults aged ≥ 40 years in the Taichung Community Health Study (TCHS) in 2004 attended a follow-up visit in 2011. Albuminuria was defined as an urinary albumin-to-creatinine ratio (UACR) ≥ 30 mg/g. Arterial stiffness was defined as BaPWV ≥ 1540 cm/sec in males and BaPWV ≥ 1480 cm/sec in females, respectively. ∆baPWV was calculated as baPWV at follow-up minus baPWV at baseline, while ∆UACR was calculated as UACR at follow-up minus UACR at baseline. Multiple linear and logistic regression analyses were used to explore the relationship between albuminuria and arterial stiffness. RESULTS: Among 652 subjects without arterial stiffness at baseline, 209 (32%) subjects developed incident arterial stiffness after an average of 6.6 years. In male subjects, baseline albuminuria was associated with development of arterial stiffness (odds ratio: 4.47, 95% confidence interval [CI]: 1.04-19.31) and ∆baPWV was modestly positively associated with ∆UACR. CONCLUSION: Our results indicated that male adults with albuminuria had an increased risk for developing arterial stiffness.