A S Gersing1, G Feuerriegel2, C Holwein3, J Suchowierski4, D C Karampinos5, B Haller6, T Baum7, B J Schwaiger8, J S Kirschke9, E J Rummeny10, A B Imhoff11, K Woertler12, P M Jungmann13. 1. Department of Radiology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany. Electronic address: alexandra.gersing@tum.de. 2. Department of Radiology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany. Electronic address: g.feuerriegel@gmail.com. 3. Department of Orthopaedic Sports Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany; Department of Trauma and Orthopaedic Surgery, BG Unfallklinik Murnau, Murnau, Germany. Electronic address: christian.holwein@klinikum-gap.de. 4. Department of Orthopaedic Sports Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany. Electronic address: joachim.suchowierski@gmail.com. 5. Department of Radiology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany. Electronic address: dimitrios.karampinos@tum.de. 6. Institute of Medical Informatics, Statistics and Epidemiology, Technical University of Munich, Munich, Germany. Electronic address: bernhard.haller@tum.de. 7. Department of Neuroradiology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany. Electronic address: thomas.baum@tum.de. 8. Department of Radiology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany. Electronic address: bschwaiger@gmx.com. 9. Department of Neuroradiology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany. Electronic address: jan.kirschke@tum.de. 10. Department of Radiology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany. Electronic address: ernst.rummeny@tum.de. 11. Department of Orthopaedic Sports Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany. Electronic address: imhoff@tum.de. 12. Department of Radiology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany. Electronic address: klaus.woertler@tum.de. 13. Department of Radiology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany; Department of Neuroradiology, University Hospital Zurich, University of Zurich, Switzerland. Electronic address: pia.jungmann@usz.ch.
Abstract
OBJECTIVE: To investigate whether T2 relaxation time measurements of cartilage repair tissue and structural changes of the knee joint are associated with subchondral bone architecture after spongiosa-augmented matrix-associated autologous chondrocyte implantation (MACI). DESIGN: Both knees of 25 patients (25.5 ± 7.8y; 10 women) were examined preoperatively and 2.7 years after unilateral spongiosa-augmented MACI with 3T magnetic resonance (MR) imaging. Cartilage composition was assessed using T2 relaxation time measurements, subchondral trabecular bone microstructure was quantified using a 3D phase-cycled balanced steady state free-precision sequence. Structural knee joint changes were assessed using the modified Whole-Organ Magnetic Resonance Imaging Score (WORMS). The Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score was used for the postoperative description of the area that underwent MACI. Correlations were assessed using Spearman's rank correlation coefficients. RESULTS: Hypertrophy of the cartilage repair tissue was found in 2 of 25 patients, both after a MACI procedure at the patella, 21 patients showed congruent filling. In subchondral bone of the cartilage repair compartment, apparent trabecular thickness was significantly higher in compartments with elevated cartilage T2 (n = 17; 0.37 ± 0.05 mm) compared to those showing no difference in cartilage T2 compared to the same compartment in the contralateral knee (n = 8; 0.27 ± 0.05 mm; P = 0.042). Significant correlations were found between the overall progression of WORMS and the ipsilateral vs contralateral ratio of average trabecular thickness (r = 0.48, P = 0.031) and bone fraction (r = 0.57, P = 0.007). CONCLUSIONS: After spongiosa-augmented MACI, T2 values of cartilage repair tissue and structural knee joint changes correlated with the quality of the underlying trabecular bone.
OBJECTIVE: To investigate whether T2 relaxation time measurements of cartilage repair tissue and structural changes of the knee joint are associated with subchondral bone architecture after spongiosa-augmented matrix-associated autologous chondrocyte implantation (MACI). DESIGN: Both knees of 25 patients (25.5 ± 7.8y; 10 women) were examined preoperatively and 2.7 years after unilateral spongiosa-augmented MACI with 3T magnetic resonance (MR) imaging. Cartilage composition was assessed using T2 relaxation time measurements, subchondral trabecular bone microstructure was quantified using a 3D phase-cycled balanced steady state free-precision sequence. Structural knee joint changes were assessed using the modified Whole-Organ Magnetic Resonance Imaging Score (WORMS). The Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score was used for the postoperative description of the area that underwent MACI. Correlations were assessed using Spearman's rank correlation coefficients. RESULTS:Hypertrophy of the cartilage repair tissue was found in 2 of 25 patients, both after a MACI procedure at the patella, 21 patients showed congruent filling. In subchondral bone of the cartilage repair compartment, apparent trabecular thickness was significantly higher in compartments with elevated cartilage T2 (n = 17; 0.37 ± 0.05 mm) compared to those showing no difference in cartilage T2 compared to the same compartment in the contralateral knee (n = 8; 0.27 ± 0.05 mm; P = 0.042). Significant correlations were found between the overall progression of WORMS and the ipsilateral vs contralateral ratio of average trabecular thickness (r = 0.48, P = 0.031) and bone fraction (r = 0.57, P = 0.007). CONCLUSIONS: After spongiosa-augmented MACI, T2 values of cartilage repair tissue and structural knee joint changes correlated with the quality of the underlying trabecular bone.
Authors: Jacky Cheung; John P Neri; Madeleine A Gao; Bin Lin; Alissa J Burge; Hollis G Potter; Kevin M Koch; Matthew F Koff Journal: HSS J Date: 2021-02-25
Authors: C Holwein; P M Jungmann; J Suchowierski; A S Gersing; K Wörtler; P U Brucker; P Angele; A B Imhoff; S Vogt Journal: Cartilage Date: 2022 Jul-Sep Impact factor: 3.117
Authors: Matthias Jung; Stefan Ruschke; Dimitrios C Karampinos; Christian Holwein; Thomas Baum; Alexandra S Gersing; Fabian Bamberg; Pia M Jungmann Journal: Cartilage Date: 2022 Jul-Sep Impact factor: 3.117