Hong Chen1, Yi Li2, Xia Gao3, Xiaohui Shen4. 1. Department of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline (Laboratory), NO. 321 Zhongshan Road, Nanjing 210008, Jiangsu, China; Research Institution of Otolaryngology, NO. 321 Zhongshan Road, Nanjing 210008, Jiangsu, China. 2. Department of Nuclear Medicine, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. Electronic address: yil15@fudan.edu.cn. 3. Department of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline (Laboratory), NO. 321 Zhongshan Road, Nanjing 210008, Jiangsu, China; Research Institution of Otolaryngology, NO. 321 Zhongshan Road, Nanjing 210008, Jiangsu, China. Electronic address: 541749457@qq.com. 4. Department of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline (Laboratory), NO. 321 Zhongshan Road, Nanjing 210008, Jiangsu, China; Research Institution of Otolaryngology, NO. 321 Zhongshan Road, Nanjing 210008, Jiangsu, China. Electronic address: 13327829269@163.com.
Abstract
PURPOSE: To evaluate the diagnostic value of 99mTc-HYNIC-TOC SPECT/CT in the detection of primary small cell neuroendocrine carcinomas of the nasal cavity and paranasal sinuses. METHODS: From September 2005 to November 2015, 19 patients (mean age 53.9 years, range 37-77; male 6, female 13) with sinonasal small cell neuroendocrine carcinoma (SNEC) underwent whole-body 99mTc-HYNIC-TOC SPECT/CT scan. RESULTS: All 19 primary lesions were detected by 99mTc-HYNIC-TOC SPECT/CT. A total of 212 metastatic lesions were identified by organ-based analysis, and the sensitivity and specificity of 99mTc-HYNIC-TOC SPECT/CT were 90.5% and 92.3%, respectively. The application of 99mTc-HYNIC-TOC SPECT/CT resulted in the detection of a higher number of lesions in 11 patients (57.9%) and in the successful alteration of the treatment in 7 patients (36.8%) compared with the morphological imaging methods. CONCLUSION: 99mTc-HYNIC-TOC scintigraphy is an effective method for the detection of the sinonasal SNEC.
PURPOSE: To evaluate the diagnostic value of 99mTc-HYNIC-TOC SPECT/CT in the detection of primary small cell neuroendocrine carcinomas of the nasal cavity and paranasal sinuses. METHODS: From September 2005 to November 2015, 19 patients (mean age 53.9 years, range 37-77; male 6, female 13) with sinonasal small cell neuroendocrine carcinoma (SNEC) underwent whole-body 99mTc-HYNIC-TOC SPECT/CT scan. RESULTS: All 19 primary lesions were detected by 99mTc-HYNIC-TOC SPECT/CT. A total of 212 metastatic lesions were identified by organ-based analysis, and the sensitivity and specificity of 99mTc-HYNIC-TOC SPECT/CT were 90.5% and 92.3%, respectively. The application of 99mTc-HYNIC-TOC SPECT/CT resulted in the detection of a higher number of lesions in 11 patients (57.9%) and in the successful alteration of the treatment in 7 patients (36.8%) compared with the morphological imaging methods. CONCLUSION: 99mTc-HYNIC-TOC scintigraphy is an effective method for the detection of the sinonasal SNEC.