| Literature DB >> 30248062 |
Siddharth Arora1, Naomi P Visanji2, Tiago A Mestre3, Athanasios Tsanas4, Amaal AlDakheel2, Barbara S Connolly5, Carmen Gasca-Salas2, Drew S Kern6, Jennifer Jain2, Elizabeth J Slow2, Achinoam Faust-Socher2, Anthony E Lang2, Max A Little7,8, Connie Marras2.
Abstract
We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations ('aaah' sounds) were recorded from 7 individuals with LRRK2-associated Parkinson's disease (PD), 17 participants with idiopathic PD (iPD), 20 non-manifesting LRRK2-mutation carriers, 25 related non-carriers, and 26 controls. In distinguishing LRRK2-associated PD and iPD, the mean sensitivity was 95.4% (SD 17.8%) and mean specificity was 89.6% (SD 26.5%). Voice features for non-manifesting carriers, related non-carriers, and controls were much less discriminatory. Vocal deficits in LRRK2-associated PD may be different than those in iPD. These preliminary results warrant longitudinal analyses and replication in larger cohorts.Entities:
Keywords: LRRK2 mutation; Parkinson’s disease; biomarker; voice
Mesh：
Substances：
Year: 2018 PMID： 30248062 DOI： 10.3233/JPD-181389
Source DB: PubMed Journal: J Parkinsons Dis ISSN： 1877-7171 Impact factor: 5.568