Literature DB >> 3024593

Effect of treatment on erythrocyte phosphoribosyl pyrophosphate synthetase and glutathione reductase activity in patients with primary gout.

J Braven, T R Hardwell, P Hickling, M Whittaker.   

Abstract

The activities of erythrocyte phosphoribosyl pyrophosphate (PRPP) synthetase and glutathione reductase (GTR) were studied in 26 patients with primary gout who were receiving no treatment or treatment with either allopurinol or azapropazone, and compared with the activity in a group of healthy controls. The activity of PRPP synthetase was significantly higher in the gout group and was not influenced by either drug. No significant difference in the activity of GTR was observed. The failure of either drug to suppress the increased activity of PRPP synthetase associated with gout is discussed.

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Year:  1986        PMID： 3024593      PMCID： PMC1002024          DOI： 10.1136/ard.45.11.941

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  13 in total

1.  Hyperlipidaemia in gout.

Authors:  Y Nishida; I Akaoka; T Nishizawa; T Yoshimura
Journal:  Clin Chim Acta       Date:  1975-07-09       Impact factor: 3.786

2.  Altered kinetic property of erythrocyte phosphoribosylpsyrophosphate synthetase in excessive purine production.

Authors:  O Sperling; P Boer; S Persky-Brosh; E Kanarek; A De Vries
Journal:  Rev Eur Etud Clin Biol       Date:  1972 Aug-Sep

3.  Human phosphoribosylpyrophosphate synthetase. Distribution, purification, and properties.

Authors:  I H Fox; W N Kelley
Journal:  J Biol Chem       Date:  1971-09-25       Impact factor: 5.157

4.  The erythrocyte glutathione reductase activity (E.C. 1.6.4.2) of healthy blood donors.

Authors:  M L Salkie; E Simpson
Journal:  J Clin Pathol       Date:  1970-11       Impact factor: 3.411

5.  Hyperlipoproteinaemia in gout.

Authors:  R Bluestone; B Lewis; I Mervart
Journal:  Ann Rheum Dis       Date:  1971-03       Impact factor: 19.103

6.  A new colorimetric method for the determination of NADH/NADPH dependent glutathione reductase in erythrocytes and in plasma.

Authors:  L Kum-Tatt; I K Tan; A M Seet
Journal:  Clin Chim Acta       Date:  1975-01-20       Impact factor: 3.786

7.  Purine overproduction in man associated with increased phosphoribosylpyrophosphate synthetase activity.

Authors:  M A Becker; L J Meyer; A W Wood; J E Seegmiller
Journal:  Science       Date:  1973-03-16       Impact factor: 47.728

8.  Glutathione reductase in red blood cells: variant associated with gout.

Authors:  W K Long
Journal:  Science       Date:  1967-02-10       Impact factor: 47.728

9.  The measurement of high density lipoprotein subfractions in patients with primary gout using a simple precipitation method.

Authors:  G A Ferns; J Lanham; J Stocks; C Ritchie; J Katz; D J Galton
Journal:  Ann Clin Biochem       Date:  1985-09       Impact factor: 2.057

10.  Secondary hypertriglyceridemia and hyperlipoproteinemia in patients with primary asymptomatic gout.

Authors:  H K Naito; A H Mackenzie
Journal:  Clin Chem       Date:  1979-03       Impact factor: 8.327
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