Literature DB >> 30245439

Simplified and automatable radiochemical separation strategy for the production of radiopharmaceutical quality 86Y using single column extraction chromatography.

Eduardo Aluicio-Sarduy1, Reinier Hernandez2, Hector F Valdovinos1, Christopher J Kutyreff1, Paul A Ellison1, Todd E Barnhart1, Robert J Nickles1, Jonathan W Engle3.   

Abstract

We present a simplified, automatable single-column radiochemical separation method using the extraction chromatographic branched-DGA resin for the production of no-carrier-added 86Y with a radiochemical yield higher than 95%, an apparent molar activity of 1.4 ± 0.4 Ci/μmol (DOTA) and 2.3 ± 0.7 Ci/μmol (DTPA), and a run-to-run recycling efficiency of the isotopically-enriched target of 98 ± 1%. These results enable the preparation of 86Y radiopharmaceuticals for 86Y/90Y-based cancer theranostic applications.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  PET; Radionuclide production; Single column extraction chromatography; Theranostic; Y-86

Year:  2018        PMID： 30245439     DOI： 10.1016/j.apradiso.2018.09.016

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  10 in total

1.  Coordination chemistry of [Y(pypa)]- and comparison immuno-PET imaging of [44Sc]Sc- and [86Y]Y-pypa-phenyl-TRC105.

Authors:  Lily Li; María de Guadalupe Jaraquemada-Peláez; Eduardo Aluicio-Sarduy; Xiaozhu Wang; Todd E Barnhart; Weibo Cai; Valery Radchenko; Paul Schaffer; Jonathan W Engle; Chris Orvig
Journal:  Dalton Trans       Date:  2020-04-09       Impact factor: 4.390

2.  Low-Dose Radiation Potentiates the Propagation of Anti-Tumor Immunity against Melanoma Tumor in the Brain after In Situ Vaccination at a Tumor outside the Brain.

Authors:  Paul A Clark; Raghava N Sriramaneni; Amber M Bates; Won Jong Jin; Justin C Jagodinsky; Reinier Hernandez; Trang Le; Justin J Jeffery; Ian R Marsh; Joseph J Grudzinski; Eduardo Aluicio-Sarduy; Todd E Barnhart; Bryce R Anderson; Ishan Chakravarty; Ian S Arthur; KyungMann Kim; Jonathan W Engle; Bryan P Bednarz; Jamey P Weichert; Zachary S Morris
Journal:  Radiat Res       Date:  2021-06-01       Impact factor: 2.841

3.  ImmunoPET: Concept, Design, and Applications.

Authors:  Weijun Wei; Zachary T Rosenkrans; Jianjun Liu; Gang Huang; Quan-Yong Luo; Weibo Cai
Journal:  Chem Rev       Date:  2020-03-23       Impact factor: 60.622

Review 4.  Imaging using radiolabelled targeted proteins: radioimmunodetection and beyond.

Authors:  Javad Garousi; Anna Orlova; Fredrik Y Frejd; Vladimir Tolmachev
Journal:  EJNMMI Radiopharm Chem       Date:  2020-06-23

5.  90Y-NM600 targeted radionuclide therapy induces immunologic memory in syngeneic models of T-cell Non-Hodgkin's Lymphoma.

Authors:  Reinier Hernandez; Kirsti L Walker; Joseph J Grudzinski; Eduardo Aluicio-Sarduy; Ravi Patel; Christopher D Zahm; Anatoly N Pinchuk; Christopher F Massey; Ariana N Bitton; Ryan J Brown; Paul M Sondel; Zachary S Morris; Jonathan W Engle; Christian M Capitini; Jamey P Weichert
Journal:  Commun Biol       Date:  2019-02-26

6.  Production and in vivo PET/CT imaging of the theranostic pair 132/135La.

Authors:  Eduardo Aluicio-Sarduy; Reinier Hernandez; Aeli P Olson; Todd E Barnhart; Weibo Cai; Paul A Ellison; Jonathan W Engle
Journal:  Sci Rep       Date:  2019-07-23       Impact factor: 4.379

7.  Safety and feasibility of an in situ vaccination and immunomodulatory targeted radionuclide combination immuno-radiotherapy approach in a comparative (companion dog) setting.

Authors:  Kara Magee; Ian R Marsh; Michelle M Turek; Joseph Grudzinski; Eduardo Aluicio-Sarduy; Jonathan W Engle; Ilene D Kurzman; Cindy L Zuleger; Elizabeth A Oseid; Christine Jaskowiak; Mark R Albertini; Karla Esbona; Bryan Bednarz; Paul M Sondel; Jamey P Weichert; Zachary S Morris; Reinier Hernandez; David M Vail
Journal:  PLoS One       Date:  2021-08-12       Impact factor: 3.752

8.  Py-Macrodipa: A Janus Chelator Capable of Binding Medicinally Relevant Rare-Earth Radiometals of Disparate Sizes.

Authors:  Aohan Hu; Eduardo Aluicio-Sarduy; Victoria Brown; Samantha N MacMillan; Kaelyn V Becker; Todd E Barnhart; Valery Radchenko; Caterina F Ramogida; Jonathan W Engle; Justin J Wilson
Journal:  J Am Chem Soc       Date:  2021-06-30       Impact factor: 16.383

9.  177Lu-NM600 Targeted Radionuclide Therapy Extends Survival in Syngeneic Murine Models of Triple-Negative Breast Cancer.

Authors:  Reinier Hernandez; Joseph J Grudzinski; Eduardo Aluicio-Sarduy; Christopher F Massey; Anatoly N Pinchuk; Ariana N Bitton; Ravi Patel; Ray Zhang; Aakarsha V Rao; Gopal Iyer; Jonathan W Engle; Jamey P Weichert
Journal:  J Nucl Med       Date:  2019-12-20       Impact factor: 10.057

10.  A High Separation Factor for 165Er from Ho for Targeted Radionuclide Therapy.

Authors:  Isidro Da Silva; Taylor R Johnson; Jason C Mixdorf; Eduardo Aluicio-Sarduy; Todd E Barnhart; R Jerome Nickles; Jonathan W Engle; Paul A Ellison
Journal:  Molecules       Date:  2021-12-11       Impact factor: 4.927
  10 in total

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