Mikkel Herly1, Mathias Ørholt2, Andreas Larsen2, Christian B Pipper3, Rikke Bredgaard2, Christina S Gramkow2, Adam J Katz4, Krzysztof T Drzewiecki2, Peter V Vester-Glowinski2. 1. Department of Plastic Surgery, Breast Surgery and Burns, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Electronic address: mikkel.herly@regionh.dk. 2. Department of Plastic Surgery, Breast Surgery and Burns, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. 3. Section of Biostatistics, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. 4. Division of Plastic and Reconstructive Surgery, University of Florida, College of Medicine, Gainesville, United States.
Abstract
BACKGROUND: Breast reconstruction with fat grafting is a new alternative to prosthetic implants and flaps for women with breast cancer. In this study, we investigate the efficacy of fat grafting for breast reconstruction in a meta-analysis. METHODS: The study followed the PRISMA and MOOSE guidelines for systematic reviews and meta-analyses. Studies were included if the patients underwent complete breast reconstruction with fat grafting as the only treatment modality. The number of fat grafting treatments needed to complete a breast reconstruction was modeled in a meta-analysis for five treatment categories: modified radical mastectomy, skin-sparing mastectomy, and breast-conserving surgery; the two mastectomy groups were subdivided into nonirradiated and irradiated. RESULTS: Twenty-one studies were included in the meta-analysis. The studies comprised 1011 breast reconstructions in 834 patients. The estimated numbers of treatments to complete a reconstruction were 2.84-4.66 in the mastectomy groups and 1.72 in the breast-conserving surgery group. The number of fat grafting sessions needed to complete a breast reconstruction was significantly higher for the irradiated patients than for the nonirradiated patients (p < 0.05). There was no significant difference in the number of fat grafting sessions needed to complete a breast reconstruction after a modified radical mastectomy versus a skin-sparing mastectomy. CONCLUSIONS: This study provides an evidence-based foundation for several practical issues related to breast reconstruction with fat grafting. The analysis showed that radiotherapy is the most important factor associated with the number of treatment sessions needed to complete a breast reconstruction and with the rate of complications.
BACKGROUND: Breast reconstruction with fat grafting is a new alternative to prosthetic implants and flaps for women with breast cancer. In this study, we investigate the efficacy of fat grafting for breast reconstruction in a meta-analysis. METHODS: The study followed the PRISMA and MOOSE guidelines for systematic reviews and meta-analyses. Studies were included if the patients underwent complete breast reconstruction with fat grafting as the only treatment modality. The number of fat grafting treatments needed to complete a breast reconstruction was modeled in a meta-analysis for five treatment categories: modified radical mastectomy, skin-sparing mastectomy, and breast-conserving surgery; the two mastectomy groups were subdivided into nonirradiated and irradiated. RESULTS: Twenty-one studies were included in the meta-analysis. The studies comprised 1011 breast reconstructions in 834 patients. The estimated numbers of treatments to complete a reconstruction were 2.84-4.66 in the mastectomy groups and 1.72 in the breast-conserving surgery group. The number of fat grafting sessions needed to complete a breast reconstruction was significantly higher for the irradiated patients than for the nonirradiated patients (p < 0.05). There was no significant difference in the number of fat grafting sessions needed to complete a breast reconstruction after a modified radical mastectomy versus a skin-sparing mastectomy. CONCLUSIONS: This study provides an evidence-based foundation for several practical issues related to breast reconstruction with fat grafting. The analysis showed that radiotherapy is the most important factor associated with the number of treatment sessions needed to complete a breast reconstruction and with the rate of complications.
Authors: Kais Razzouk; Alfred Fitoussi; Noor Al Khori; Jennifer Pasquier; Lotfi Chouchane; Arash Rafii Tabrizi Journal: Plast Reconstr Surg Glob Open Date: 2020-05-26
Authors: Nestor M Diaz Deleon; Sandeep Adem; Christopher V Lavin; Darren B Abbas; Michelle Griffin; Megan E King; Mimi R Borrelli; Ronak A Patel; Evan J Fahy; Daniel Lee; Abra H Shen; Arash Momeni; Michael T Longaker; Derrick C Wan Journal: J Tissue Eng Regen Med Date: 2021-10-05 Impact factor: 3.963