Biodistribution and Excretion of Intravenously Injected Mesoporous Silica Nanoparticles: Implications for Drug Delivery Efficiency and Safety.

Mesoporous silica nanoparticles (MSNs) are currently attracting a high interest for use as drug carriers in vivo. To date only data on the biodistribution in small animals are available. As any nanoparticle system, the MSNs typically accumulate in the RES organs lung, liver, and spleen upon intravenous (i.v.) administration. However, the literature data are partly inconclusive, which can be connected to the wide variability of the experimental designs, differing for example in particle size and shape, mesopore size, and surface functionalization, as well as the animal models used, the amount administered, and the means for particle detection. The present review is an attempt to summarize the literature to date with main focus on the increasing number of studies related to quantitative full body distributions. Whenever possible, attempts are also made to discuss differences in experimental observations between studies. Finally, an outlook is given listing some open issues, and highlighting the need for more standardized experimental designs in order to allow for a faster identification of optimal particle characteristics for drug delivery applications of MSNs.