| Literature DB >> 30244469 |
Abstract
Bone homeostasis depends on balanced bone deposition and bone resorption, which are mediated by osteoblasts and osteoclasts, respectively. As one therapeutic strategy, the blockage of osteoclast activity reduces subsequent bone erosion. Morphological analysis of bone resorption pits formed by osteoclasts by using scanning electron microscope is an effective method for understanding rheumatoid arthritis. Here we describe methods for observing surface microstructure of pits formed by osteoclasts on hard tissue sections.Entities:
Keywords: Bone resorption pit; Bone slice; Electric conductive; Ion sputtering coat; Osteoclast; SEM
Mesh：
Substances：
Year: 2018 PMID： 30244469 DOI： 10.1007/978-1-4939-8802-0_22
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745