Jorge Calvillo-Arbizu1, Miguel A Pérez-Valdivia2, Miguel A Gentil-Govantes2, Pablo Castro-de-la-Nuez3, Auxiliadora Mazuecos-Blanca4, Alberto Rodríguez-Benot5, María C Gracia-Guindo6, Francisco Borrego-Utiel7, Mercedes Cabello-Díaz8, Rafael Bedoya-Pérez9, Manuel Alonso-Gil3, Mercedes Salgueira-Lazo10, Laura M Roa-Romero11. 1. Grupo de Ingeniería Biomédica, Universidad de Sevilla, Sevilla, España; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), España. Electronic address: jorgecalvilloarbizu@gmail.com. 2. Hospital Universitario Virgen del Rocío, Sevilla, España. 3. Coordinación Autonómica de Trasplante de Andalucía, Sevilla, España. 4. Hospital Puerta del Mar, Cádiz, España. 5. Hospital Reina Sofía, Córdoba, España. 6. Hospital Virgen de las Nieves, Granada, España. 7. Hospital de Jaén, Jaén, España. 8. Hospital Regional de Málaga, Málaga, España. 9. Hospital Infantil Virgen del Rocío, Sevilla, España. 10. Grupo de Ingeniería Biomédica, Universidad de Sevilla, Sevilla, España; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), España; Hospital Universitario Virgen Macarena, Sevilla, España. 11. Grupo de Ingeniería Biomédica, Universidad de Sevilla, Sevilla, España; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), España.
Abstract
BACKGROUND AND OBJECTIVE: The Kidney Donor Profile Index (KDPI), together with other donor and recipient variables, can optimise the organ allocation process. This study aims to check the feasibility of the KDPI for a Spanish population and its predictive ability of graft and patient survival. MATERIALS AND METHODS: Data from 2,734 kidney transplants carried out in Andalusia between January 2006 and December 2015 were studied. Cases were grouped by recipient age, categorised by KDPI quartile and both graft and patient survival were compared among groups. RESULTS: The KDPI accurately discriminated optimal organs from suboptimal or marginal ones. For adult recipients (aged: 18-59years) it presents a hazard ratio of 1.013 (P<.001) for death-censored graft survival and of 1.013 (P=.007) for patient survival. For elderly recipients (aged: 60+years), KDPI presented a hazard ratio of 1.016 (P=.001) for death-censored graft survival and of 1.011 (P=.007) for patient survival. A multivariate analysis identified the KDPI, donor age, donation after circulatory death, recipient age and gender as predictive factors of graft survival. CONCLUSIONS: The results obtained show that the KDPI makes it possible to relate the donor's characteristics with the greater or lesser survival of the graft and the patient in the Spanish population. However, due to certain limitations, a new index for Spain based on Spanish or European data should be created. In this study, some predictive factors of graft survival are identified that may serve as a first step in this path.
BACKGROUND AND OBJECTIVE: The Kidney Donor Profile Index (KDPI), together with other donor and recipient variables, can optimise the organ allocation process. This study aims to check the feasibility of the KDPI for a Spanish population and its predictive ability of graft and patient survival. MATERIALS AND METHODS: Data from 2,734 kidney transplants carried out in Andalusia between January 2006 and December 2015 were studied. Cases were grouped by recipient age, categorised by KDPI quartile and both graft and patient survival were compared among groups. RESULTS: The KDPI accurately discriminated optimal organs from suboptimal or marginal ones. For adult recipients (aged: 18-59years) it presents a hazard ratio of 1.013 (P<.001) for death-censored graft survival and of 1.013 (P=.007) for patient survival. For elderly recipients (aged: 60+years), KDPI presented a hazard ratio of 1.016 (P=.001) for death-censored graft survival and of 1.011 (P=.007) for patient survival. A multivariate analysis identified the KDPI, donor age, donation after circulatory death, recipient age and gender as predictive factors of graft survival. CONCLUSIONS: The results obtained show that the KDPI makes it possible to relate the donor's characteristics with the greater or lesser survival of the graft and the patient in the Spanish population. However, due to certain limitations, a new index for Spain based on Spanish or European data should be created. In this study, some predictive factors of graft survival are identified that may serve as a first step in this path.
Authors: F Villanego; L A Vigara; J M Cazorla; J Naranjo; L Atienza; A M Garcia; M E Montero; M C Minguez; T Garcia; A Mazuecos Journal: Transpl Int Date: 2022-06-06 Impact factor: 3.842
Authors: Mehdi Maanaoui; François Provôt; Sébastien Bouyé; Arnaud Lionet; Rémi Lenain; Victor Fages; Marie Frimat; Céline Lebas; François Glowacki; Marc Hazzan Journal: Sci Rep Date: 2021-06-09 Impact factor: 4.379
Authors: Armando Coca; Carlos Arias-Cabrales; Ana Lucía Valencia; Carla Burballa; Juan Bustamante-Munguira; Dolores Redondo-Pachón; Isabel Acosta-Ochoa; Marta Crespo; Jesús Bustamante; Alicia Mendiluce; Julio Pascual; María José Pérez-Saéz Journal: Sci Rep Date: 2020-10-13 Impact factor: 4.379