Sophie Parat1, Véronique Nègre2, Amandine Baptiste3, Paul Valensi4, Anne-Marie Bertrand5, Christine Chollet6, Myriam Dabbas7, Jean-Jacques Altman8, Alexandre Lapillonne9, Jean-Marc Tréluyer3, Caroline Elie3, Maithé Tauber10, Françoise Lorenzini11, Emmanuel Cosson4,12. 1. AP-HP, Department of Medecine and Neonatal Reanimation, Hôpital Cochin-Port Royal, Paris, France. sophie.parat@aphp.fr. 2. RePPOP-Franche Comte Network for Pediatric Obesity, Obesity Specialized Center CHU Nice, Paris, France. 3. URC/CIC Paris Descartes Necker Cochin, Paris, France. 4. AP-HP, CRNH-IdF, CINFO, COMUE Sorbonne-Paris-Cité, Department of Endocrinology-Diabetology-Nutrition, Jean Verdier Hospital, Bondy, France. 5. Department of Pediatric Endocrinology, CHRU, Besançon, France. 6. Childhood Hospital and RePPOP Midi Pyrenees Network for Pediatric Obesity, Toulouse, France. 7. AP-HP, Nutrition Obesity Unit, Necker Hospital, Paris, France. 8. AP-HP, Department of Diabetology, HEGP, Paris, France. 9. AP-HP, Department of Neonatology, Paris Descartes University, Hôpital Necker, Paris, France. 10. Department of Pediatric Endocrinology, Childhood Hospital and RePPOP Midi Pyrenees Network for Pediatric Obesity, Toulouse, France. 11. Department of Endocrinology, Paule Viguier Hospital, Toulouse, France. 12. Université Paris 13, Inserm (U1153), Inra (U1125), Centre d'Epidémiologie et Statistiques Paris Cité, Cnam, COMUE Sorbonne-Paris-Cité, F-93017, Bobigny, France.
Abstract
BACKGROUND: We aimed to evaluate whether pre and perinatal education of pregnant women would reduce childhood overweight. METHODS: Four French centers included women at ≤21 gestational weeks (GWs) with body mass index (BMI) >25 kg/m2 before pregnancy. Patients were randomized to a control group (routine care including at least one dietary visit) or an intervention group (2 individuals (26 and 30 GW) and 4 group sessions (21, 28, 35 GW, 2 months postpartum)) aimed at educating the future mother regarding infant and maternal nutrition. The primary objective was to reduce post-natal excessive weight gain in the infant from birth to 2 years (NCT00804765). This project was funded by a grant from the National Programme for Hospital Research (PHRC-2007 French Ministry of Health). RESULTS: We included 275 women (BMI: 32.5 kg/m2). The rate of post-natal excessive weight gain was similar in the intervention (n = 132) and control (n = 136) groups by intention to treat (ITT: 59.1% vs 60.3% respectively, p = 0.84) in available data (AD, n = 206) and by per-protocol analysis (PP, n = 177). Two years after delivery, normalization of maternal BMI and number of infants with BMI < 19 kg/m2 were not significantly different in the interventional group in ITT and in the control group. Although not significantly different in ITT, normalization of maternal BMI was more frequent in AD (n = 149: 12.9% vs 3.8%, p = 0.04) and 2-year-old infant BMIs were less likely to be >19 kg/m2 in the intervention group in AD (n = 204: 0% vs 6.8%, p = 0.014) and PP (n = 176: 0% vs 6.4%, p = 0.03). CONCLUSIONS: An education and nutritional counseling program for overweight women, starting after 3 months of gestation, did not significantly change post-natal excessive weight gain of infants or prevent overweight in mothers and children 2 years after delivery.
BACKGROUND: We aimed to evaluate whether pre and perinatal education of pregnant women would reduce childhood overweight. METHODS: Four French centers included women at ≤21 gestational weeks (GWs) with body mass index (BMI) >25 kg/m2 before pregnancy. Patients were randomized to a control group (routine care including at least one dietary visit) or an intervention group (2 individuals (26 and 30 GW) and 4 group sessions (21, 28, 35 GW, 2 months postpartum)) aimed at educating the future mother regarding infant and maternal nutrition. The primary objective was to reduce post-natal excessive weight gain in the infant from birth to 2 years (NCT00804765). This project was funded by a grant from the National Programme for Hospital Research (PHRC-2007 French Ministry of Health). RESULTS: We included 275 women (BMI: 32.5 kg/m2). The rate of post-natal excessive weight gain was similar in the intervention (n = 132) and control (n = 136) groups by intention to treat (ITT: 59.1% vs 60.3% respectively, p = 0.84) in available data (AD, n = 206) and by per-protocol analysis (PP, n = 177). Two years after delivery, normalization of maternal BMI and number of infants with BMI < 19 kg/m2 were not significantly different in the interventional group in ITT and in the control group. Although not significantly different in ITT, normalization of maternal BMI was more frequent in AD (n = 149: 12.9% vs 3.8%, p = 0.04) and 2-year-old infant BMIs were less likely to be >19 kg/m2 in the intervention group in AD (n = 204: 0% vs 6.8%, p = 0.014) and PP (n = 176: 0% vs 6.4%, p = 0.03). CONCLUSIONS: An education and nutritional counseling program for overweight women, starting after 3 months of gestation, did not significantly change post-natal excessive weight gain of infants or prevent overweight in mothers and children 2 years after delivery.
Authors: Marion Lecorguillé; Madalina Jacota; Blandine de Lauzon-Guillain; Anne Forhan; Marie Cheminat; Marie-Aline Charles; Barbara Heude Journal: PLoS Med Date: 2019-08-20 Impact factor: 11.069
Authors: Roxana Raab; Sophie Michel; Julia Günther; Julia Hoffmann; Lynne Stecher; Hans Hauner Journal: Int J Behav Nutr Phys Act Date: 2021-01-07 Impact factor: 6.457