Literature DB >> 30242042

Mallostery: Filling a niche between quality and metabolic control.

Ngee Kiat Chua1, Andrew J Brown2.   

Abstract

To be, or not to be … What determines the destruction of a protein in response to metabolic cues? In the current issue of JBC, Wangeline and Hampton shed new light on this existential question by studying the classic case of HMGCR (Hmg2 in yeast), the rate-limiting step in sterol synthesis, and find a metabolic cue that causes "allosteric misfolding" and subsequent destruction of the protein, a concept they name mallostery.
© 2018 Chua and Brown.

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Year:  2018        PMID： 30242042      PMCID： PMC6153292          DOI： 10.1074/jbc.H118.005031

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  10 in total

1.  "Mallostery"-ligand-dependent protein misfolding enables physiological regulation by ERAD.

Authors:  Margaret A Wangeline; Randolph Y Hampton
Journal:  J Biol Chem       Date:  2018-07-17       Impact factor: 5.157

2.  Regulation of synthesis and degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by low density lipoprotein and 25-hydroxycholesterol in UT-1 cells.

Authors:  J R Faust; K L Luskey; D J Chin; J L Goldstein; M S Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

3.  Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast.

Authors:  Renee M Garza; Peter N Tran; Randolph Y Hampton
Journal:  J Biol Chem       Date:  2009-12-18       Impact factor: 5.157

4.  UbiA prenyltransferase domain-containing protein-1 modulates HMG-CoA reductase degradation to coordinate synthesis of sterol and nonsterol isoprenoids.

Authors:  Marc M Schumacher; Dong-Jae Jun; Brittany M Johnson; Russell A DeBose-Boyd
Journal:  J Biol Chem       Date:  2017-11-22       Impact factor: 5.157

5.  Distinct sterol and nonsterol signals for the regulated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase.

Authors:  J Roitelman; R D Simoni
Journal:  J Biol Chem       Date:  1992-12-15       Impact factor: 5.157

Review 6.  Proteostatic Tactics in the Strategy of Sterol Regulation.

Authors:  Margaret A Wangeline; Nidhi Vashistha; Randolph Y Hampton
Journal:  Annu Rev Cell Dev Biol       Date:  2017-10-06       Impact factor: 13.827

7.  Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis.

Authors:  Anika V Prabhu; Winnie Luu; Laura J Sharpe; Andrew J Brown
Journal:  J Biol Chem       Date:  2016-02-17       Impact factor: 5.157

Review 8.  Underlying mechanisms for sterol-induced ubiquitination and ER-associated degradation of HMG CoA reductase.

Authors:  Brittany M Johnson; Russell A DeBose-Boyd
Journal:  Semin Cell Dev Biol       Date:  2017-11-07       Impact factor: 7.727

9.  A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis.

Authors:  Ngee Kiat Chua; Vicky Howe; Nidhi Jatana; Lipi Thukral; Andrew J Brown
Journal:  J Biol Chem       Date:  2017-09-27       Impact factor: 5.157

10.  Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast.

Authors:  R Y Hampton; J Rine
Journal:  J Cell Biol       Date:  1994-04       Impact factor: 10.539
  10 in total
  2 in total

1.  Celebrating science's next generation.

Authors:  Lila M Gierasch; George DeMartino
Journal:  J Biol Chem       Date:  2019-03-01       Impact factor: 5.157

2.  The Degron Architecture of Squalene Monooxygenase and How Specific Lipids Calibrate Levels of This Key Cholesterol Synthesis Enzyme.

Authors:  Ngee Kiat Chua; Andrew J Brown
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622
  2 in total

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