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Literature DB >> 30237809

STATINS AND BONE HEALTH: A MINI REVIEW.

Leslie R Morse^1,2, Jennifer Coker¹, Ricardo A Battaglino².

Abstract

Statins are a widely prescribed class of medications that inhibit similar pathways as the anti-resorptive bisphosphonate drugs. Statins target the mevalonate pathway by blocking HMG-CoA reductase. Several recent meta-analyses concluded statins are osteoprotective in the general population. Here we present current literature exploring the mechanisms underlying the putative osteoprotective effects of statins. We also review recent clinical studies, ranging from observational cohort studies to randomized clinical trials, testing the effect of statins on bone health in various populations.

Entities: Chemical Disease Gene Species

Keywords: bone loss; fracture healing; statins

Year: 2018 PMID： 30237809 PMCID： PMC6143288

Source DB: PubMed Journal: Actual osteol ISSN： 1669-8975

26 in total

1. HMG-CoA reductase inhibitors (statins) and bone mineral density: a meta-analysis.

Authors: Jie Liu; Li-Ping Zhu; Xu-Li Yang; He-Lang Huang; Dong-Qing Ye
Journal: Bone Date: 2013-02-04 Impact factor: 4.398

2. Effect of simvastatin treatment on bone mineral density and bone turnover in hypercholesterolemic postmenopausal women: a 1-year longitudinal study.

Authors: A Montagnani; S Gonnelli; C Cepollaro; S Pacini; M S Campagna; M B Franci; B Lucani; C Gennari
Journal: Bone Date: 2003-04 Impact factor: 4.398

3. Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts.

Authors: K Ohnaka; S Shimoda; H Nawata; H Shimokawa; K Kaibuchi; Y Iwamoto; R Takayanagi
Journal: Biochem Biophys Res Commun Date: 2001-09-21 Impact factor: 3.575

4. Effects of statins on bone mineral density: a meta-analysis of clinical studies.

Authors: Bernard Uzzan; Régis Cohen; Patrick Nicolas; Michel Cucherat; Gérard-Yves Perret
Journal: Bone Date: 2007-03-01 Impact factor: 4.398

5. HMG-CoA reductase inhibitors increase BMD in type 2 diabetes mellitus patients.

Authors: Y S Chung; M D Lee; S K Lee; H M Kim; L A Fitzpatrick
Journal: J Clin Endocrinol Metab Date: 2000-03 Impact factor: 5.958

6. The cornucopia of "pleiotropic" actions of statins: myogenesis as a new mechanism for statin-induced benefits?

Authors: Roberto Bolli; Buddhadeb Dawn
Journal: Circ Res Date: 2009-01-30 Impact factor: 17.367

7. Transdermal lovastatin enhances fracture repair in rats.

Authors: Gloria E Gutierrez; James R Edwards; Ian R Garrett; Jeffry S Nyman; Brandon McCluskey; Gianni Rossini; Alda Flores; Daria B Neidre; Gregory R Mundy
Journal: J Bone Miner Res Date: 2008-11 Impact factor: 6.741

8. Effects of simvastatin on bone turnover and BMD: a 1-year randomized controlled trial in postmenopausal osteopenic women.

Authors: Lars Rejnmark; Niels Henrik Buus; Peter Vestergaard; Lene Heickendorff; Frederik Andreasen; Mogens Lytken Larsen; Leif Mosekilde
Journal: J Bone Miner Res Date: 2004-02-16 Impact factor: 6.741

STATINS AND BONE HEALTH: A MINI REVIEW.

1. HMG-CoA reductase inhibitors (statins) and bone mineral density: a meta-analysis.

2. Effect of simvastatin treatment on bone mineral density and bone turnover in hypercholesterolemic postmenopausal women: a 1-year longitudinal study.

3. Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts.

4. Effects of statins on bone mineral density: a meta-analysis of clinical studies.

5. HMG-CoA reductase inhibitors increase BMD in type 2 diabetes mellitus patients.

6. The cornucopia of "pleiotropic" actions of statins: myogenesis as a new mechanism for statin-induced benefits?

7. Transdermal lovastatin enhances fracture repair in rats.

8. Effects of simvastatin on bone turnover and BMD: a 1-year randomized controlled trial in postmenopausal osteopenic women.

9. Locally delivered lovastatin nanoparticles enhance fracture healing in rats.

10. Locally applied Simvastatin improves fracture healing in mice.

Review 1. Crosstalk of Brain and Bone-Clinical Observations and Their Molecular Bases.

Review 2. Regulation of Osteoclast Differentiation and Activity by Lipid Metabolism.