| Literature DB >> 30237134 |
Thanasan Nilsu1, Wachirasak Thaisaeng2, Wanlaya Thamnarak2, Chatchakorn Eurtivong3, Apiwan Jumraksa3, Sakornrat Thorroad2, Nisachon Khunnawutmanotham4, Somsak Ruchirawat5, Nopporn Thasana6.
Abstract
Phytochemical constituents in alkaloid extracts from three Thai club mosses Huperzia squarrosa, Huperzia phlegmaria and Phlegmariurus nummularifolius were investigated. Squarrosinoxide was an undescribed Lycopodium alkaloid from H. squarrosa possessing an unprecedented 6/5/7 tricyclic spiro system. Acetyllycophlegmarianol was an undescribed N-oxide lycopodine-type alkaloid isolated from H. phlegmaria. 4-Epilycopodine, an undescribed epimer of lycopodine, was first isolated from P. nummularifolius. The structural assignments were established through comprehensive spectroscopic techniques and chemical correlations. All compounds were assayed for their anti-acetylcholinesterase activity in vitro.Entities:
Keywords: Acetylcholinesterase inhibitor; Huperzia phlegmaria; Huperzia squarrosa; Lycopodiaceae; Lycopodium alkaloid; Phlegmariurus nummularifolius
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Year: 2018 PMID： 30237134 DOI： 10.1016/j.phytochem.2018.09.001
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072