Literature DB >> 3023700

Effects of S-adenosylhomocysteine and analogs on Epstein-Barr virus-induced transformation, expression of the Epstein-Barr virus capsid antigen, and methylation of Epstein-Barr virus DNA.

W K Long, G E Fronko, R G Lindemeyer, B Wu, E E Henderson.   

Abstract

S-Adenosylhomocysteine was found to have no effect on Epstein-Barr virus-induced transformation of B-lymphocytes and to stimulate viral capsid antigen expression only slightly in the FF41-1 cell line. In contrast, the S-adenosylhomocysteine analogs sinefungin and S-isobutyladenosine inhibited Epstein-Barr virus transformation and induced a significant increase in the numbers of cells expressing the viral capsid antigen. An inverse relationship between levels of viral DNA methylation and gene expression was demonstrated.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3023700      PMCID： PMC255247     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  28 in total

1.  Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2'-deoxycytidine.

Authors:  F Creusot; G Acs; J K Christman
Journal:  J Biol Chem       Date:  1982-02-25       Impact factor: 5.157

2.  Conservation and progressive methylation of Epstein-Barr viral DNA sequences in transformed cells.

Authors:  C Kintner; B Sugden
Journal:  J Virol       Date:  1981-04       Impact factor: 5.103

3.  A fraction of Epstein--Barr virus virion DNA is methylated in and around the EcoRI-J fragment.

Authors:  C Perlmann; A K Saemundsen; G Klein
Journal:  Virology       Date:  1982-11       Impact factor: 3.616

Review 4.  Enhancer elements.

Authors:  G Khoury; P Gruss
Journal:  Cell       Date:  1983-06       Impact factor: 41.582

5.  DNA methylation of three 5' C-C-G-G 3' sites in the promoter and 5' region inactivate the E2a gene of adenovirus type 2.

Authors:  K D Langner; L Vardimon; D Renz; W Doerfler
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

6.  Induction of Epstein-Barr virus antigens by tumor promoters for epidermal and nonepidermal tissues.

Authors:  K Takada; H Zur Hausen
Journal:  Int J Cancer       Date:  1984-04-15       Impact factor: 7.396

7.  Activation of the Epstein-Barr virus genome by 5-aza-cytidine in latently infected human lymphoid lines.

Authors:  S A Ben-Sasson; G Klein
Journal:  Int J Cancer       Date:  1981-08-15       Impact factor: 7.396

8.  Effect of 5-azacytidine on differentiation and DNA methylation in human promyelocytic leukemia cells (HL-60).

Authors:  J K Christman; N Mendelsohn; D Herzog; N Schneiderman
Journal:  Cancer Res       Date:  1983-02       Impact factor: 12.701

9.  Specifically unmethylated cytidylic-guanylate sites in Herpesvirus saimiri DNA in tumor cells.

Authors:  R C Desrosiers
Journal:  J Virol       Date:  1982-08       Impact factor: 5.103

10.  Genome of a mononucleosis Epstein-Barr virus contains DNA fragments previously regarded to be unique to Burkitt's lymphoma isolates.

Authors:  D K Fischer; G Miller; L Gradoville; L Heston; M W Westrate; W Maris; J Wright; J Brandsma; W C Summers
Journal:  Cell       Date:  1981-05       Impact factor: 41.582
View more
  2 in total

Review 1.  DNA methylation as a target for drug design.

Authors:  C M Bender; J M Zingg; P A Jones
Journal:  Pharm Res       Date:  1998-02       Impact factor: 4.200

2.  Antiviral effect of sinefungin on in vitro growth of feline herpesvirus type 1.

Authors:  Yudai Kuroda; Haruka Yamagata; Michiko Nemoto; Kenji Inagaki; Takashi Tamura; Ken Maeda
Journal:  J Antibiot (Tokyo)       Date:  2019-09-18       Impact factor: 2.649
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.