Chunmeng Wei1, Yasi Li2, Kaiming Huang1, Gang Li1, Min He1,3. 1. School of Public Health, Guangxi Medical University, Nanning 530021, PR China. 2. College of Arts & Sciences, Stony Brook University, NY 11790, USA. 3. Key Laboratory of High-Incidence Tumor Prevention & Treatment (Guangxi Medical University), Ministry of Education, PR China.
Abstract
AIM: The aim was to systematically evaluate whether exosomal miRNAs could be regarded as potential minimally invasive biomarkers of diagnosis for gastrointestinal cancer. METHODS: A systematic review and meta analysis of exosomal miRNA expression in gastrointestinal cancer were performed. RESULTS: A total of 370 articles were retrieved from PubMed and EMBASE. The summary receiver operating characteristic curves of three miRNAs (miR-21, miR-1246 and miR-4644) were drawn, miR-21, miR-1246 and miR-4644 exhibited sensitivities of 0.66, 0.920 and 0.750, respectively; specificities were 0.87, 0.958 and 0.769, respectively; and areas under the curve for discriminating gastrointestinal cancer patients from control subjects were 0.876, 0.969 and 0.827, respectively. CONCLUSION: Exosome miR-1246 had the highest level of diagnostic efficiency, which indicated that miR-1246 could be a biomarker.
AIM: The aim was to systematically evaluate whether exosomal miRNAs could be regarded as potential minimally invasive biomarkers of diagnosis for gastrointestinal cancer. METHODS: A systematic review and meta analysis of exosomal miRNA expression in gastrointestinal cancer were performed. RESULTS: A total of 370 articles were retrieved from PubMed and EMBASE. The summary receiver operating characteristic curves of three miRNAs (miR-21, miR-1246 and miR-4644) were drawn, miR-21, miR-1246 and miR-4644 exhibited sensitivities of 0.66, 0.920 and 0.750, respectively; specificities were 0.87, 0.958 and 0.769, respectively; and areas under the curve for discriminating gastrointestinal cancerpatients from control subjects were 0.876, 0.969 and 0.827, respectively. CONCLUSION: Exosome miR-1246 had the highest level of diagnostic efficiency, which indicated that miR-1246 could be a biomarker.
Authors: Gleb O Skryabin; Andrey V Komelkov; Kirill I Zhordania; Dmitry V Bagrov; Svetlana V Vinokurova; Sergey A Galetsky; Nadezhda V Elkina; Darya A Denisova; Adel D Enikeev; Elena M Tchevkina Journal: Cells Date: 2022-03-22 Impact factor: 6.600