| Literature DB >> 3023590 |
B K Lam, E Marcinkiewicz, J Quilley, A Hirai, S Yoshida, Y Tamura, P Y Wong.
Abstract
Oral administration of pure eicosapentaenoic acid (EPA) ethyl ester caused a reversible hypotensive effect in spontaneously hypertensive rats. Treatment with EPA also lowered the platelet response to ADP and inhibited the conversion of leucotrienes (LTs) A4 and LTB4 and other sulphidopeptide leucotrienes. Therefore, diet supplemented with EPA may lower blood pressure in hypertensive rats and affect cardiovascular functions which may be mediated through eicosanoid metabolism.Entities:
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Year: 1986 PMID： 3023590
Source DB: PubMed Journal: J Hypertens Suppl ISSN： 0952-1178