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Literature DB >> 3023544

Endogenous benzodiazepine receptor agonist in human and mammalian plasma.

Abstract

Using ultra-filtration steps and HPLC-separation, a low molecular weight ligand of the benzodiazepine receptor was isolated from plasma of various mammalian species including man. The endogenous ligand acts on benzodiazepine receptors agonistically and apparently has a receptor affinity similar to Diazepam. The ligand is not identical with Diazepam as indicated by HPLC and UV-spectroscopy.

Entities: Chemical Species

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Year: 1986 PMID： 3023544 DOI： 10.1007/bf01260910

Source DB: PubMed Journal: J Neural Transm Impact factor: 3.575

14 in total

1. Nicotinamide is a brain constituent with benzodiazepine-like actions.

Authors: H Möhler; P Polc; R Cumin; L Pieri; R Kettler
Journal: Nature Date: 1979-04-05 Impact factor: 49.962

2. Synaptic pharmacology of barbiturates and benzodiazepines.

Authors: W E Haefely
Journal: Agents Actions Date: 1977-09

3. Diazepam receptor characterization: specific binding of a benzodiazepine to macromolecules in various areas of rat brain.

Authors: H B Bosmann; K R Case; P DiStefano
Journal: FEBS Lett Date: 1977-10-15 Impact factor: 4.124

4. Agonist and antagonist benzodiazepine receptor interaction in vitro.

Authors: H Möhler; J G Richards
Journal: Nature Date: 1981-12-24 Impact factor: 49.962

5. Identification of inosine and hypoxanthine as endogenous inhibitors of [3H] diazepam binding in the central nervous system.

Authors: P Skolnick; P J Marangos; F K Goodwin; M Edwards; S Paul
Journal: Life Sci Date: 1978-10-09 Impact factor: 5.037

6. Inhibition of diazepam binding by tryptophan derivatives including melatonin and its brain metabolite N-acetyl-5-methoxy kynurenamine.

Authors: P J Marangos; J Patel; F Hirata; D Sondhein; S M Paul; P Skolnick; F K Goodwin
Journal: Life Sci Date: 1981-07-20 Impact factor: 5.037

7. Stimulation of benzodiazepine receptor binding by gamma-aminobutyric acid.

Authors: M Karobath; G Sperk
Journal: Proc Natl Acad Sci U S A Date: 1979-02 Impact factor: 11.205

8. Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons.

Authors: R E Study; J L Barker
Journal: Proc Natl Acad Sci U S A Date: 1981-11 Impact factor: 11.205

5. Effect of flumazenil on recovery from anesthesia and the bispectral index after sevoflurane/fentanyl general anesthesia in unpremedicated patients.

Authors: Yi Jeong Kim; Heeseung Lee; Chi Hyo Kim; Guie Yong Lee; Hee Jung Baik; Jong In Han
Journal: Korean J Anesthesiol Date: 2012-01-25

5 in total

Endogenous benzodiazepine receptor agonist in human and mammalian plasma.

1. Nicotinamide is a brain constituent with benzodiazepine-like actions.

2. Synaptic pharmacology of barbiturates and benzodiazepines.

3. Diazepam receptor characterization: specific binding of a benzodiazepine to macromolecules in various areas of rat brain.

4. Agonist and antagonist benzodiazepine receptor interaction in vitro.

5. Identification of inosine and hypoxanthine as endogenous inhibitors of [3H] diazepam binding in the central nervous system.

6. Inhibition of diazepam binding by tryptophan derivatives including melatonin and its brain metabolite N-acetyl-5-methoxy kynurenamine.

7. Stimulation of benzodiazepine receptor binding by gamma-aminobutyric acid.

8. Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons.

9. Demonstration of benzodiazepine-like molecules in the mammalian brain with a monoclonal antibody to benzodiazepines.

Review 10. Receptors for the age of anxiety: pharmacology of the benzodiazepines.

Review 1. Endogenous GABAergic modulators in the pathogenesis of hepatic encephalopathy.

2. Porphyrins are endogenous ligands for the mitochondrial (peripheral-type) benzodiazepine receptor.

3. Diazepam and N-desmethyldiazepam are found in rat brain and adrenal and may be of plant origin.

4. Purification of endogenous inhibitors of [3H]flunitrazepam binding from bovine brain.

5. Effect of flumazenil on recovery from anesthesia and the bispectral index after sevoflurane/fentanyl general anesthesia in unpremedicated patients.