Literature DB >> 3023514

Effect of pentoxifylline on the phagocytic activity, cAMP levels, and superoxide anion production by monocytes and polymorphonuclear cells.

H Bessler, R Gilgal, M Djaldetti, I Zahavi.   

Abstract

The effect of pentoxifylline (Trental) on the phagocytic capacity, cAMP levels, and superoxide anion production of human peripheral blood monocytes and polymorphonuclears (PMNs) was studied. The drug inhibited the phagocytosis of latex particles by both monocytes and PMNs in a dose-dependent manner. In addition, superoxide anion production during the phagocytic process was also reduced following incubation of the cells with pentoxifylline. It is suggested that this inhibitory effect is due to the increased intracellular levels of cAMP induced by the drug.

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Year:  1986        PMID： 3023514     DOI： 10.1002/jlb.40.6.747

Source DB:  PubMed          Journal:  J Leukoc Biol        ISSN： 0741-5400            Impact factor:   4.962


  40 in total

Review 1.  The pulmonary physician and critical care. 3. Pharmacotherapy in lung injury.

Authors:  M Messent; M J Griffiths
Journal:  Thorax       Date:  1992-08       Impact factor: 9.139

2.  Attenuation of spontaneous pseudopod formation in human neutrophils by pentoxifylline.

Authors:  P M Wong; G W Schmid-Schönbein
Journal:  Cell Biophys       Date:  1991-06

Review 3.  Roles of proinflammatory and anti-inflammatory cytokines in pathophysiology of bacterial meningitis and effect of adjunctive therapy.

Authors:  A M van Furth; J J Roord; R van Furth
Journal:  Infect Immun       Date:  1996-12       Impact factor: 3.441

4.  Use of pentoxifylline as an inhibitor of free radical generation in peripheral vascular disease. Results of a double-blind placebo-controlled study.

Authors:  G Ciuffetti; M Mercuri; C Ott; R Lombardini; R Paltriccia; G Lupattelli; L Santambrogio; E Mannarino
Journal:  Eur J Clin Pharmacol       Date:  1991       Impact factor: 2.953

5.  Studies of skin-window exudate human neutrophils: increased resistance to pentoxifylline of the respiratory burst in primed cells.

Authors:  A Carletto; D Biasi; L M Bambara; P Caramaschi; M L Bonazzi; S Lussignoli; G Andrioli; P Bellavite
Journal:  Inflammation       Date:  1997-04       Impact factor: 4.092

6.  Pentoxifylline-induced modulation of human leukocyte function in vitro.

Authors:  K Josaki; J Contrino; J Kristie; P Krause; D L Kreutzer
Journal:  Am J Pathol       Date:  1990-03       Impact factor: 4.307

7.  Pentoxifylline modulation of plasma membrane functions in human polymorphonuclear leukocytes.

Authors:  W L Hand; M L Butera; N L King-Thompson; D L Hand
Journal:  Infect Immun       Date:  1989-11       Impact factor: 3.441

8.  Effect of pentoxifylline on tumor suppressor and proto-oncogene apoptosis in sperm.

Authors:  David T Maxwell; John D Jacobson; Alan King; Philip J Chan
Journal:  J Assist Reprod Genet       Date:  2002-06       Impact factor: 3.412

9.  Differential effects of pentoxifylline on the production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) by monocytes and T cells.

Authors:  L Schandené; P Vandenbussche; A Crusiaux; M L Alègre; D Abramowicz; E Dupont; J Content; M Goldman
Journal:  Immunology       Date:  1992-05       Impact factor: 7.397

Review 10.  Pharmacotherapy of acute lung injury and acute respiratory distress syndrome.

Authors:  Krishnan Raghavendran; Gloria S Pryhuber; Patricia R Chess; Bruce A Davidson; Paul R Knight; Robert H Notter
Journal:  Curr Med Chem       Date:  2008       Impact factor: 4.530
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