Kursat Bora Carman1, Mustafa Calik2, Yasemin Karal3, Sedat Isikay4, Ozan Kocak5, Aysima Ozcelik6, Ahmet Sami Yazar7, Cagatay Nuhoglu8, Cigdem Sag8, Omer Kilic9, Meltem Dinleyici10, Sibel Lacinel Gurlevik1, Sevgi Yimenicioglu11, Arzu Ekici12, Peren Perk6, Ayse Tosun13, Ilhan Isik14, Coskun Yarar1, Didem Arslantas15, Ener Cagri Dinleyici16. 1. a Faculty of Medicine, Department of Pediatric Neurology , Eskisehir Osmangazi University , Eskisehir , Turkey. 2. b Faculty of Medicine, Department of Pediatric Neurology , Harran University , Sanliurfa , Turkey. 3. c Faculty of Medicine, Department of Pediatric Neurology , Trakya University , Edirne , Turkey. 4. d Faculty of Medicine, Department of Pediatric Neurology , Hasan Kalyoncu University , Gaziantep , Turkey. 5. e Department of Pediatric Neurology , Samsun Education and Research Hospital , Samsun , Turkey. 6. f Faculty of Medicine, Department of Pediatric Neurology , Gaziantep University , Gaziantep , Turkey. 7. g Department of Pediatrics , Umraniye Education and Research Hospital , Istanbul , Turkey. 8. h Department of Pediatrics , Haydarapasa Numune Education and Research Hospital , Istanbul , Turkey. 9. i Faculty of Medicine, Pediatric Infectious Disease Unit , Eskisehir Osmangazi University , Eskisehir , Turkey. 10. j Faculty of Medicine, Department of Social Pediatrics , Eskisehir Osmangazi University , Eskisehir , Turkey. 11. k Department of Pediatric Neurology , Eskisehir Maternity and Children Hospital , Eskisehir , Turkey. 12. l Department of Pediatric Neurology , Bursa Yuksek Ihtisas Training and Research Hospital , Bursa , Turkey. 13. m Faculty of Medicine, Department of Pediatric Neurology , Adnan Menderes University , Aydin , Turkey. 14. n Department of Pediatric Neurology , Sanliurfa Children's Hospital , Sanliurfa , Turkey. 15. o Faculty of Medicine, Department of Public Health , Eskisehir Osmangazi University , Eskisehir , Turkey. 16. p Faculty of Medicine, Department of Pediatrics , Eskisehir Osmangazi University , Eskisehir , Turkey.
Abstract
BACKGROUND: Febrile seizure is the most common childhood neurological disorder, is an important health problem with potential short- and long-term complications, also leading to economic burden and increased parental anxiety about fevers and seizures occurring in their children. There are no routine recommendation to detect etiological causes of FS for neurological perspective, further knowledge about the etiological causes of FS in children will support preventive measures and follow-up strategies. The aim of this study is to evaluate the percentage of respiratory viruses in children with FS. METHODS: This prospective multicenter study, entitled "Viral etiological causes of febrile seizures for respiratory pathogens (EFES Study)" examined representative populations in eight different cities in Turkey between March 1, 2016 and April 1, 2017. Nasopharyngeal swabs were taken from all children at presentation. A respiratory multiplex array was performed to detect for influenza A and B; respiratory syncytial virus A and B; human parainfluenza virus 1-2-3 and 4; human coronavirus 229E and OC43; human rhinovirus; human enterovirus; human adenovirus; human bocavirus; human metapneumovirus. RESULTS: During the study period, at least one virus was detected in 82.7% (144/174) of children with FS. The most frequently detected virus was adenovirus, followed by influenza A and influenza B. Detection of more than one virus was present in 58.3% of the children with FS, and the most common co-existence was the presence of adenovirus and influenza B. In children younger than 12 months, Coronavirus OC43 was the most common, while influenza A was most frequently observed in children older than 48 months (p < 0.05). Human bocavirus was common in children who experienced complex FS, while respiratory syncytial virus (RSV) A was more common in children who experienced simple FS. Influenza B virus was the most common virus identified in children who were experiencing their first incidence of FS (p < 0.05). CONCLUSIONS: This study indicates that respiratory viruses are important in the etiology of FS in children. The results show that antibiotics must be prescribed carefully in children with FS since the majority of cases are related to viral causes. Widespread use of the existing quadrivalent influenza vaccine might be useful for the prevention of FS related to the flu. Further vaccine candidates for potential respiratory pathogens, including RSV, might be helpful for the prevention of FS.
BACKGROUND:Febrile seizure is the most common childhood neurological disorder, is an important health problem with potential short- and long-term complications, also leading to economic burden and increased parental anxiety about fevers and seizures occurring in their children. There are no routine recommendation to detect etiological causes of FS for neurological perspective, further knowledge about the etiological causes of FS in children will support preventive measures and follow-up strategies. The aim of this study is to evaluate the percentage of respiratory viruses in children with FS. METHODS: This prospective multicenter study, entitled "Viral etiological causes of febrile seizures for respiratory pathogens (EFES Study)" examined representative populations in eight different cities in Turkey between March 1, 2016 and April 1, 2017. Nasopharyngeal swabs were taken from all children at presentation. A respiratory multiplex array was performed to detect for influenza A and B; respiratory syncytial virus A and B; human parainfluenza virus 1-2-3 and 4; human coronavirus 229E and OC43; human rhinovirus; human enterovirus; human adenovirus; human bocavirus; human metapneumovirus. RESULTS: During the study period, at least one virus was detected in 82.7% (144/174) of children with FS. The most frequently detected virus was adenovirus, followed by influenza A and influenza B. Detection of more than one virus was present in 58.3% of the children with FS, and the most common co-existence was the presence of adenovirus and influenza B. In children younger than 12 months, Coronavirus OC43 was the most common, while influenza A was most frequently observed in children older than 48 months (p < 0.05). Human bocavirus was common in children who experienced complex FS, while respiratory syncytial virus (RSV) A was more common in children who experienced simple FS. Influenza B virus was the most common virus identified in children who were experiencing their first incidence of FS (p < 0.05). CONCLUSIONS: This study indicates that respiratory viruses are important in the etiology of FS in children. The results show that antibiotics must be prescribed carefully in children with FS since the majority of cases are related to viral causes. Widespread use of the existing quadrivalent influenza vaccine might be useful for the prevention of FS related to the flu. Further vaccine candidates for potential respiratory pathogens, including RSV, might be helpful for the prevention of FS.
Authors: Varvara Probst; Emily K Datyner; Zaid Haddadin; Danielle A Rankin; Lubna Hamdan; Herdi K Rahman; Andrew Spieker; Laura S Stewart; Claudia Guevara; Erin Yepsen; Jonathan E Schmitz; Natasha B Halasa Journal: J Clin Virol Date: 2020-12-11 Impact factor: 3.168
Authors: Ariane J Brown; John J Won; Rachel L Graham; Kenneth H Dinnon; Amy C Sims; Joy Y Feng; Tomas Cihlar; Mark R Denison; Ralph S Baric; Timothy P Sheahan Journal: Antiviral Res Date: 2019-06-21 Impact factor: 5.970
Authors: Rachelle Dugue; Karla C Cay-Martínez; Kiran T Thakur; Joel A Garcia; Lokendra V Chauhan; Simon H Williams; Thomas Briese; Komal Jain; Marc Foca; Danielle K McBrian; Jennifer M Bain; W Ian Lipkin; Nischay Mishra Journal: Neurology Date: 2020-04-23 Impact factor: 9.910
Authors: J Matías-Guiu; U Gomez-Pinedo; P Montero-Escribano; P Gomez-Iglesias; J Porta-Etessam; J A Matias-Guiu Journal: Neurologia (Engl Ed) Date: 2020-04-06