John W Shumway1, Renzhong Ran2, Jeff McClusky3, Zubaid Rafique2, Cedric Dark2, W Frank Peacock2, Alexie Cintron4, Michelle Ludwig5. 1. Department of Radiation Oncology, Baylor College of Medicine, Houston, Texas. 2. Department of Emergency Medicine, Baylor College of Medicine, Houston, Texas. 3. Pharmacy Services, Harris Health System, Harris Health System, Houston, Texas. 4. Department of Medicine, Section of Geriatrics, Baylor College of Medicine, Houston, Texas. 5. Assistant Professor, Department of Radiation Oncology, Baylor College of Medicine, Houston, Texas; Adjunct Assistant Professor, Division of Epidemiology, Human Genetics & Environmental Sciences, UT School of Public Health, Dallas, Texas; Smith Clinic, Attwell Radiation Therapy Center, Houston, Texas.
Abstract
OBJECTIVE: The objective of this study was to examine the rescheduling of hydrocodone-combination products (HCPs) and associated changes in prescriber patterns in an urban county healthcare system in Texas. METHODS: Pharmacy data were obtained electronically for tramadol, hydrocodone-acetaminophen, and acetaminophen-codeine from 180 days before and after the schedule change on October 6, 2014. x2 and t tests were used to calculate the significance of changes between the medications over the studied time. RESULTS: Hydrocodone-acetaminophen saw a decline in dispense events and pills dispensed of 80.2 and 67.9 percent, respectively, in the immediate 30-day period following the scheduling change with a total decrease of 80.8 and 67.5 percent, respectively, in the 180-day period. Acetaminophen-codeine dispense events and total pills dispensed increased by 302.3 and 288.9 percent, respectively, in the immediate 30-day period while 180-day results experienced an increase of 215.1 and 209.8 percent, respectively. There were no major changes with tramadol. Additionally, an increase of 69.5 percent in pills per dispense event of hydroco-done-acetaminophen was noted in the 180-day period following the schedule change. CONCLUSION: The scheduling change of HCPs is associated with an immediate decrease in hydrocodone-acetaminophen use at our institution while a simultaneous rise in acetaminophen-codeine products was observed.
OBJECTIVE: The objective of this study was to examine the rescheduling of hydrocodone-combination products (HCPs) and associated changes in prescriber patterns in an urban county healthcare system in Texas. METHODS: Pharmacy data were obtained electronically for tramadol, hydrocodone-acetaminophen, and acetaminophen-codeine from 180 days before and after the schedule change on October 6, 2014. x2 and t tests were used to calculate the significance of changes between the medications over the studied time. RESULTS:Hydrocodone-acetaminophen saw a decline in dispense events and pills dispensed of 80.2 and 67.9 percent, respectively, in the immediate 30-day period following the scheduling change with a total decrease of 80.8 and 67.5 percent, respectively, in the 180-day period. Acetaminophen-codeine dispense events and total pills dispensed increased by 302.3 and 288.9 percent, respectively, in the immediate 30-day period while 180-day results experienced an increase of 215.1 and 209.8 percent, respectively. There were no major changes with tramadol. Additionally, an increase of 69.5 percent in pills per dispense event of hydroco-done-acetaminophen was noted in the 180-day period following the schedule change. CONCLUSION: The scheduling change of HCPs is associated with an immediate decrease in hydrocodone-acetaminophen use at our institution while a simultaneous rise in acetaminophen-codeine products was observed.