Literature DB >> 30234444

Optimization of the Platelet-Rich Plasma Concentration for Mesenchymal Stem Cell Applications.

Ketao Wang1, Zhongli Li1, Ji Li1, Weixiong Liao1, Yuanyuan Qin2, Ning Zhang1, Xiulin Huo1, Ning Mao3, Heng Zhu3.   

Abstract

IMPACT STATEMENT: In the current study, we screened the effects of different concentrations of platelet-rich plasma (PRP) on the mesenchymal stem cell (MSC) proliferation and differentiation. Our data demonstrated that concentrated PRP exerted different effects on cell proliferation and on the osteogenic, adipogenic, and chondrogenic differentiation of human bone marrow-derived MSCs. Meanwhile, we optimized PRP concentrations for each of these lineage differentiation and MSC expansion and, thus, suggested several promising clinical strategies for different kinds of diseases. These findings may help explain the controversial effects of PRP on MSCs and improve the progress in precise applications of PRP-based regenerative strategies.

Entities:  

Keywords:  differentiation; mesenchymal stem cells; optimization of concentrations; platelet-rich plasma; precise treatment; proliferation

Mesh：

Substances：

Year:  2018        PMID： 30234444     DOI： 10.1089/ten.TEA.2018.0091

Source DB:  PubMed          Journal:  Tissue Eng Part A        ISSN： 1937-3341            Impact factor:   3.845


  12 in total

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Authors:  Konstantinos Sfakianoudis; Anna Rapani; Sokratis Grigoriadis; Dimitra Retsina; Evangelos Maziotis; Petroula Tsioulou; Polina Giannelou; Konstantinos Pantos; Michael Koutsilieris; Nikolaos Vlahos; George Mastorakos; Mara Simopoulou
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2.  Defect-adaptive Stem-cell-microcarrier Construct Promotes Tissue Repair in Rabbits with Knee Cartilage Defects.

Authors:  Zhidong Zhao; Yuxing Wang; Bofeng Yin; Xiaotong Li; Ruicong Hao; Zhiling Li; Peilin Li; Mengyue Han; Li Ding; Zhongli Li; Heng Zhu
Journal:  Stem Cell Rev Rep       Date:  2022-07-28       Impact factor: 6.692

3.  The optimal platelet concentration in platelet-rich plasma for proliferation of human cells in vitro-diversity, biases, and possible basic experimental principles for further research in the field: A review.

Authors:  Olav K Straum
Journal:  PeerJ       Date:  2020-11-13       Impact factor: 2.984

Review 4.  Technical Procedures for Preparation and Administration of Platelet-Rich Plasma and Related Products: A Scoping Review.

Authors:  Daniela Vianna Pachito; Ângela Maria Bagattini; Adriano Marques de Almeida; Alfredo Mendrone-Júnior; Rachel Riera
Journal:  Front Cell Dev Biol       Date:  2020-12-11

5.  Effect of Platelet-rich Plasma on Implant Bone Defects in Rabbits Through the FAK/PI3K/AKT Signaling Pathway.

Authors:  Wei Liu; Ben Chen; Youyang Zheng; Yuehua Shi; Zhuojin Shi
Journal:  Open Life Sci       Date:  2019-07-10       Impact factor: 0.938

6.  Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women.

Authors:  Konstantinos Sfakianoudis; Mara Simopoulou; Sokratis Grigoriadis; Agni Pantou; Petroula Tsioulou; Evangelos Maziotis; Anna Rapani; Polina Giannelou; Nikolaos Nitsos; Georgia Kokkali; Michael Koutsilieris; Konstantinos Pantos
Journal:  J Clin Med       Date:  2020-06-10       Impact factor: 4.241

7.  3D printing of silk fibroin-based hybrid scaffold treated with platelet rich plasma for bone tissue engineering.

Authors:  Liang Wei; Shaohua Wu; Mitchell Kuss; Xiping Jiang; Runjun Sun; Patrick Reid; Xiaohong Qin; Bin Duan
Journal:  Bioact Mater       Date:  2019-09-25

8.  Biological potential alterations of migratory chondrogenic progenitor cells during knee osteoarthritic progression.

Authors:  Yu-Xing Wang; Zhi-Dong Zhao; Qian Wang; Zhong-Li Li; Ya Huang; Sen Zhao; Wei Hu; Jia-Wu Liang; Pei-Lin Li; Hua Wang; Ning Mao; Chu-Tse Wu; Heng Zhu
Journal:  Arthritis Res Ther       Date:  2020-03-27       Impact factor: 5.156

9.  Systematic Review-The Potential Implications of Different Platelet-Rich Plasma (PRP) Concentrations in Regenerative Medicine for Tissue Repair.

Authors:  Pietro Gentile; Simone Garcovich
Journal:  Int J Mol Sci       Date:  2020-08-09       Impact factor: 5.923

10.  Orchestrated cellular, biochemical, and biomechanical optimizations endow platelet-rich plasma-based engineered cartilage with structural and biomechanical recovery.

Authors:  Ketao Wang; Ji Li; Yuxing Wang; Yaqiang Wang; Yuanyuan Qin; Fei Yang; Mingzhu Zhang; Heng Zhu; Zhongli Li
Journal:  Bioact Mater       Date:  2021-04-10
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