| Literature DB >> 30234309 |
Yuan Li1,2,3, Hui-Xin Lin1, Jian Wang1, Jian Yang1, Chang-Jiang-Sheng Lai1, Xing Wang3,4, Bao-Wei Ma3,4, Jin-Fu Tang1, Yong Li1,2, Xin-Lin Li3,4, Juan Guo1, Wei Gao3,4,5, Lu-Qi Huang1,2.
Abstract
ApUGT, a diterpene glycosyltransferase from Andrographis paniculata, could transfer a glucose to the C-19 hydroxyl moiety of andrograpanin to form neoandrographolide. This glycosyltransferase has a broad substrate scope, and it can glycosylate 26 natural and unnatural compounds of different structural types. This study provides a basis for exploring the glycosylation mechanism of ent-labdane-type diterpenes and plays an important role in diversifying the structures used in drug discovery.Entities:
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Year: 2018 PMID： 30234309 DOI： 10.1021/acs.orglett.8b02146
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005