Literature DB >> 30232713

Protective effects of Brazilian propolis supplementation on capillary regression in the soleus muscle of hindlimb-unloaded rats.

Masayuki Tanaka1, Miho Kanazashi2, Noriaki Maeshige3, Hiroyo Kondo4, Akihiko Ishihara5, Hidemi Fujino6.   

Abstract

The protective effects of Brazilian propolis on capillary regression induced by chronically neuromuscular inactivity were investigated in rat soleus muscle. Four groups of male Wistar rat were used in this study; control (CON), control plus Brazilian propolis supplementation (CON + PP), 2-week hindlimb unloading (HU), and 2-week hindlimb unloading plus Brazilian propolis supplementation (HU + PP). The rats in the CON + PP and HU + PP groups received two oral doses of 500 mg/kg Brazilian propolis daily (total daily dose 1000 mg/kg) for 2 weeks. Unloading resulted in a decrease in capillary number, luminal diameter, and capillary volume, and an increase in the expression of anti-angiogenic factors, such as p53 and TSP-1, within the soleus muscle. Brazilian propolis supplementation, however, prevented these changes in capillary structure due to unloading through the stimulation of pro-angiogenic factors and suppression of anti-angiogenic factors. These results suggest that Brazilian propolis is a potential non-drug therapeutic agent against capillary regression induced by chronic unloading.

Entities:  

Keywords:  Anti-angiogenic factors; Brazilian propolis; Capillary regression; Hindlimb unloading; Muscle atrophy; Oxidative stress

Mesh：

Substances：

Year:  2018        PMID： 30232713     DOI： 10.1007/s12576-018-0639-z

Source DB:  PubMed          Journal:  J Physiol Sci        ISSN： 1880-6546            Impact factor:   2.781


  50 in total

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2.  Growth inhibitory activity of ethanol extracts of Chinese and Brazilian propolis in four human colon carcinoma cell lines.

Authors:  Masashi Ishihara; Kuniko Naoi; Masanari Hashita; Yoshinori Itoh; Masumi Suzui
Journal:  Oncol Rep       Date:  2009-08       Impact factor: 3.906

3.  Electrical stimulation prevents immobilization atrophy in skeletal muscle of rabbits.

Authors:  L Qin; H J Appell; K M Chan; N Maffulli
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4.  Regression of capillary network in atrophied soleus muscle induced by hindlimb unweighting.

Authors:  Hidemi Fujino; Hisaharu Kohzuki; Isao Takeda; Takahiko Kiyooka; Takehiro Miyasaka; Satoshi Mohri; Juichiro Shimizu; Fumihiko Kajiya
Journal:  J Appl Physiol (1985)       Date:  2004-12-10

5.  Amelioration of capillary regression and atrophy of the soleus muscle in hindlimb-unloaded rats by astaxanthin supplementation and intermittent loading.

Authors:  Miho Kanazashi; Masayuki Tanaka; Shinichiro Murakami; Hiroyo Kondo; Fumiko Nagatomo; Akihiko Ishihara; Roland R Roy; Hidemi Fujino
Journal:  Exp Physiol       Date:  2014-06-06       Impact factor: 2.969

6.  Salidroside, a scavenger of ROS, enhances the radioprotective effect of Ex-RAD® via a p53-dependent apoptotic pathway.

Authors:  Tian Feng; Libin Wang; Nan Zhou; Chang Liu; Jiahui Cui; Rangxin Wu; Juan Jing; Shengyong Zhang; Hui Chen; Siwang Wang
Journal:  Oncol Rep       Date:  2017-09-06       Impact factor: 3.906

Review 7.  Modes of p53 regulation.

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Journal:  Cell       Date:  2009-05-15       Impact factor: 41.582

8.  Murine double minute-2 expression is required for capillary maintenance and exercise-induced angiogenesis in skeletal muscle.

Authors:  Emilie Roudier; Paul Forn; Mary Ellen Perry; Olivier Birot
Journal:  FASEB J       Date:  2012-07-26       Impact factor: 5.191

9.  Protective effects of astaxanthin on capillary regression in atrophied soleus muscle of rats.

Authors:  M Kanazashi; Y Okumura; S Al-Nassan; S Murakami; H Kondo; F Nagatomo; N Fujita; A Ishihara; R R Roy; H Fujino
Journal:  Acta Physiol (Oxf)       Date:  2012-10-22       Impact factor: 6.311

10.  Suppression of tumor-induced angiogenesis by Brazilian propolis: major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation.

Authors:  Mok-Ryeon Ahn; Kazuhiro Kunimasa; Toshiro Ohta; Shigenori Kumazawa; Miya Kamihira; Kazuhiko Kaji; Yoshihiro Uto; Hitoshi Hori; Hideko Nagasawa; Tsutomu Nakayama
Journal:  Cancer Lett       Date:  2007-03-06       Impact factor: 8.679
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  5 in total

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Authors:  Tomohiro Matsumoto; Masayuki Tanaka; Takuya Ikeji; Noriaki Maeshige; Yoshitada Sakai; Toshihiro Akisue; Hiroyo Kondo; Akihiko Ishihara; Hidemi Fujino
Journal:  J Physiol Sci       Date:  2018-11-26       Impact factor: 2.781

Review 2.  Effects of Propolis Extract and Propolis-Derived Compounds on Obesity and Diabetes: Knowledge from Cellular and Animal Models.

Authors:  Hiroshi Kitamura
Journal:  Molecules       Date:  2019-12-01       Impact factor: 4.411

3.  Effects of astaxanthin supplementation and electrical stimulation on muscle atrophy and decreased oxidative capacity in soleus muscle during hindlimb unloading in rats.

Authors:  Miho Kanazashi; Masayuki Tanaka; Ryosuke Nakanishi; Noriaki Maeshige; Hidemi Fujino
Journal:  J Physiol Sci       Date:  2019-07-04       Impact factor: 2.781

4.  Antioxidant activity and protective effect of propolis against carbon tetrachloride-induced liver and kidney injury by modulation of oxidative parameters.

Authors:  Redouan El-Haskoury; Noori Al-Waili; Zeineb Kamoun; Mohamed Makni; Ahmed Al-Waili; Badiaa Lyoussi
Journal:  Vet World       Date:  2021-12-08

5.  Green propolis extract attenuates acute kidney injury and lung injury in a rat model of sepsis.

Authors:  Marcelo Augusto Duarte Silveira; José Manuel Condor Capcha; Talita Rojas Sanches; Roberto de Sousa Moreira; Margot S Garnica; Maria Heloisa Shimizu; Andresa Berretta; Flávio Teles; Irene L Noronha; Lúcia Andrade
Journal:  Sci Rep       Date:  2021-03-15       Impact factor: 4.379
  5 in total

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