Literature DB >> 3023247

Assignment and conformation of neurotensin in aqueous solution by 1H NMR.

J L Nieto, M Rico, J Santoro, J Herranz, F J Bermejo.   

Abstract

A complete assignment of exchangeable and unexchangeable proton resonances of neurotensin 1-13 in aqueous solution has been carried out with the help of its 1-8 and 8-13 fragments. To detect formation of a secondary structure, the effects of peptide fragmentation, temperature decrease, pH changes and addition of denaturing agents on the neurotensin 1H NMR spectrum were investigated. The small changes observed in all cases support the conclusion that neurotensin exists mainly as a flexible random coiled polypeptidic chain in aqueous solution in agreement with previous CD studies.

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Year:  1986        PMID： 3023247     DOI： 10.1111/j.1399-3011.1986.tb03261.x

Source DB:  PubMed          Journal:  Int J Pept Protein Res        ISSN： 0367-8377


  3 in total

1.  Rational design of novel neurotensin mimetics: discovery of a pharmacologically unprecedented agent exhibiting concentration-dependent dual effects as antagonist and full agonist.

Authors:  Y P Pang; J Zaidi; A P Kozikowski; B Cusack; E Richelson
Journal:  J Comput Aided Mol Des       Date:  1994-08       Impact factor: 3.686

2.  Conformational Changes in Tyrosine 11 of Neurotensin Are Required to Activate the Neurotensin Receptor 1.

Authors:  Fabian Bumbak; Trayder Thomas; Billy J Noonan-Williams; Tasneem M Vaid; Fei Yan; Alice R Whitehead; Shoni Bruell; Martina Kocan; Xuan Tan; Margaret A Johnson; Ross A D Bathgate; David K Chalmers; Paul R Gooley; Daniel J Scott
Journal:  ACS Pharmacol Transl Sci       Date:  2020-04-29

3.  The conformation of neurotensin bound to its G protein-coupled receptor.

Authors:  Sorin Luca; Jim F White; Awinder K Sohal; Dmitri V Filippov; Jacques H van Boom; Reinhard Grisshammer; Marc Baldus
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-05       Impact factor: 11.205
  3 in total

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