Examining protective and buffering associations between sociocultural factors and adverse childhood experiences among American Indian adults with type 2 diabetes: a quantitative, community-based participatory research approach.

OBJECTIVES: The purpose of this study was to determine the frequency of select adverse childhood experiences (ACEs) among a sample of American Indian (AI) adults living with type 2 diabetes (T2D) and the associations between ACEs and self-rated physical and mental health. We also examined associations between sociocultural factors and health, including possible buffering processes.
DESIGN: Survey data for this observational study were collected using computer-assisted survey interviewing techniques between 2013 and 2015.
SETTING: Participants were randomly selected from AI tribal clinic facilities on five reservations in the upper Midwestern USA. PARTICIPANTS: Inclusion criteria were a diagnosis of T2D, age 18 years or older and self-identified as AI. The sample includes n=192 adults (55.7% female; mean age=46.3 years). PRIMARY MEASURES: We assessed nine ACEs related to household dysfunction and child maltreatment. Independent variables included social support, diabetes support and two cultural factors: spiritual activities and connectedness. Primary outcomes were self-rated physical and mental health.
RESULTS: An average of 3.05 ACEs were reported by participants and 81.9% (n=149) said they had experienced at least one ACE. Controlling for gender, age and income, ACEs were negatively associated with self-rated physical and mental health (p<0.05). Connectedness and social support were positively and significantly associated with physical and mental health. Involvement in spiritual activities was positively associated with mental health and diabetes-specific support was positively associated with physical health. Social support and diabetes-specific social support moderated associations between ACEs and physical health.
CONCLUSIONS: This research demonstrates inverse associations between ACEs and well-being of adult AI patients with diabetes. The findings further demonstrate the promise of social and cultural integration as a critical component of wellness, a point of relevance for all cultures. Health professionals can use findings from this study to augment their assessment of patients and guide them to health-promoting social support services and resources for cultural involvement. © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is the first quantitative observational study of which we are aware to examine American Indian (AI) adult cultural and social protective factors in the face of earlier life adversities, including moderating relationships between adverse childhood experiences (ACEs) and adult self-rated mental and physical health.

Study scope and methodology was developed using community-based participatory research principles to promote authentic researcher/community member collaboration.

We contribute to a limited body of literature on ACEs and AI health by assessing ACE exposure and correlates for a clinical sample of Native adults.

Retrospective reports of ACEs that may involve systematic error including recall bias should be considered when interpreting findings.

Introduction

Adverse childhood experiences (ACEs) are early life stressful situations or traumatic events that often co-occur and are potent determinants of health linked to increased morbidity and mortality across the life course.1–9 The foundational Centers for Disease Control and Prevention (CDC) Kaiser Permanente ACEs retrospective adult studies (Kaiser/CDC studies) identified a set of 8–10 childhood stressors including childhood emotional, physical and sexual abuse, emotional and physical neglect, witnessing intimate partner violence, parental separation and living with a substance abusing, mentally ill or incarcerated household member.5 6 These childhood stressors, or ACEs, have been shown to correspond with later life outcomes, such as type 2 diabetes (T2D), substance abuse and suicide attempts, with graded, positive relationships between the number of ACE exposures and risk for health outcomes.5 6 10 Adaptations of the Kaiser/CDC indexes have expanded ACE criteria to include, for example, peer isolation and rejection,11 peer victimisation,12 community level indicators like community violence12 and poverty.13 In the absence of protective factors, existing evidence suggests that early trauma and toxic stress can have lasting effects on physical and mental health.3 5 6 11

The emerging literature on ACEs among the American Indian/Alaska Native (AI/AN) population has identified disproportionately high rates of ACEs and childhood stressors that are associated with multiple health outcomes including suicidality,7 substance misuse,8 diabetes14 and worse mental health including depressive symptoms.15 16 There is also movement to identify ACEs appropriate for AI/AN culture and context, such as historical loss associated symptoms and discrimination.7 Elevated and unique experiences with ACEs offer explanation for the pronounced health inequities experienced by AI/AN communities, including heightened rates of T2D. For example, data from 2013 to 2015 indicated adult overall prevalence of T2D for AI/ANs was 15.1%, versus 7.4% for non-Hispanic whites.17 Further, T2D represents a modern epidemic among AI/ANs, especially considering that prior to the 1940s, the diagnosis was relatively uncommon for this demographic.18

In the wake of such compelling evidence that ACEs can lead to serious health consequences, researchers have begun identifying factors that may provide a protective effect against ACE impacts.19 One way in which protective factors operate is through the fostering, building and exertion of resilience as an ability to overcome significant life stressors.20–24 In a US sample, factors such as sense of community have been shown to have direct and indirect protective effects on ACEs, including moderating roles for the impact of ACEs on adult mental health.25

Resilience promotion is not a new concept within Tribal communities. AI/ANs have longstanding traditional knowledge that include instructions on how to stay well and thrive, and Indigenous theoretical literature supports the assertion that sociocultural resources and cultural participation is health-promoting.26–28 AI/AN resilience is dynamic and accessed through familial, communal and cultural knowledge and expressions (eg, traditional activity participation, spiritual practices, positive identity promotion, social support, feelings of connectedness to family and nature).26 28 These deeply rooted beliefs and practices have been identified as multilevel factors that can buffer poor outcomes, strengthen resilience and promote health.29

Preventing ACEs and increasing access to and participation in resilience-building opportunities could contribute to closing the health equity gap for AI communities. An examination of moderating and health promoting factors is particularly salient for Tribal communities given complex health service delivery systems and limited systemic resources for monitoring and addressing behavioural health on reservations.21 30 Despite this great need, few studies have examined AI/AN-specific protective factors or resilience contributors in the context of ACEs. As an exception, Burnette and colleagues (2015) found that social support had a protective effect on depressive symptoms among AI/AN older adults who experienced ACEs.15 In another study, youth who experienced child maltreatment and other stressors had a reduced likelihood of suicidality if they discussed problems with friends or family and reported connectedness with family.30 However, no AI/AN-specific studies of which we are aware have investigated adult cultural and social protective factors in the face of earlier life adversities and their potential for moderating the relationship between ACEs and adult self-rated mental and physical health.

The purpose of this study is to (1) determine the frequency of select ACEs within a sample of AI/AN adults living with T2D and (2) examine associations between ACEs, social supports, cultural factors and self-rated physical and mental health. Three hypotheses guided our inquiry:

H1: ACEs will be negatively associated with self-reported physical and mental health status.

H2: Social support (general and diabetes-specific) and Indigenous cultural factors will be positively associated with self-reported physical and mental health status.

H3: Social support and cultural factors will buffer (moderate) the associations between ACEs and physical and mental health.

Methods

The Maawaji’ idi-oog Mino-ayaawin (Gathering for Health) project is a community-based participatory research collaboration between the University of Minnesota and five AI (ie, Ojibwe) communities. The primary purpose of the study was to understand sources of stress and examine their impact on T2D-related outcomes for AIs. Tribal resolutions supporting the project were granted by all five tribal nation governments.

Patient and public involvement

Community Research Councils (CRCs) from each tribe worked closely with the university research team to develop and implement study protocols, participate in data collection, interpretation and dissemination. Members of the CRCs included patients living with T2D, patient providers, community members and elders. As such, patient perspectives were incorporated into the design and conduct of this study. All CRCs read and/or provided comments on this manuscript prior to journal submission, and the paper was approved for submission by the Indian Health Service (IHS) National Institutional Review Board. Participants received a mailed infographic summarising major overall study results. In addition, the research team has/will continue to present findings within each tribal community via written technical reports and in-person presentations at local health fairs, tribal council meetings and public gatherings.

Procedure and sample

The study involved two major phases: (1) a qualitative step including two sets of focus groups to identify salient community stressors and adapt/develop survey measures and (2) a quantitative phase including survey data from computer-assisted personal interviews (CAPI; details below). The goal of this process was to maximise measurement validity for local culture and contexts. Prior to CAPI field entry, we also piloted any adapted or new measures with a convenience sample of AI participants and asked for open-ended feedback on question applicability and comprehension. Feedback from pilot surveys permitted us to further refine measures in collaboration with CRC members. Data presented in this study are from Phase II CAPI responses.

Staff at each IHS clinic site generated simple random samples for Phase II study recruitment from patient records. Inclusion criteria were a diagnosis of T2D, age 18 years or older and self-identified as AI/AN. A total of 194 participants enrolled in the study, representing a baseline response rate of 67%.

Clinic staff sent study letters of invitation and brochures to residences of randomly selected patients. Non-refusing individuals were contacted and screened for eligibility by trained community interviewers. Visits were scheduled at a location of participants’ choosing, at which time interviewers gathered signed informed consent and HIPAA authorisation forms prior to administering surveys. We analysed responses from the 192 participants for which we have baseline CAPI completed from 2013 to 2015. Participants received a $50 incentive and a small, culturally meaningful gift for their participation.

Measures

Three control variables were included in analyses: age (in years), gender (male=0, female=1) and per capita household income were each assessed via self-report survey responses. Two dependent variables, self-rated mental health and self-rated physical health, each ranged in value from 0 (poor) to 4 (excellent); thus, higher scores indicate better health. A continuous ACEs measure was created by summing affirmative responses to nine experiences related to household dysfunction, and child maltreatment; participants were included in this continuous measure if they answered at least five of the nine ACE items (n=182; Cronbach’s alpha=0.77).

Several protective independent variables were also included. Social support was assessed by nine items adapted from a previous measure of perceived emotional and instrumental support received from others.31 Example items include: there is at least one person I can share most things with; I have someone to help me if I am physically unwell; I feel that I have a circle of people who value me and when I am feeling down, there is someone I can lean on (Cronbach’s alpha=0.89). Diabetes-specific support (adapted from Fitzgerald)32 includes five items and assesses perceived support directly related to diabetes management including help to follow a healthy meal plan, handle feelings about diabetes, and test (my) blood sugar (Cronbach’s alpha=0.86). Traditional spiritual activities include summed ‘yes’ responses to nine spiritually relevant cultural activities, such as seeking advice/guidance from a spiritual advisor or participating in a sweat lodge, which were engaged in during the prior year (Cronbach’s alpha=0.81). We also used an adapted Awareness of Connectedness33 measure that included six items assessing degree of connection to nature, family and community (eg, I feel connected to nature; When I am hurting, my family hurts with me; My community’s happiness is a part of my happiness; Cronbach’s alpha=0.74). A full listing of survey measures included in this manuscript is provided as an online supplementary file.

Statistical analysis

We used SPSS V.24 to conduct all analyses with list-wise deletion of missing values, including ordinary least squares (OLS) regression analyses for multivariate models. There were few missing cases across variables; full sample responses were given for age, gender, income and spiritual activities, and missing data for remaining variables ranges from 1 to 4 cases total, with the exception of individual ACE items (table 1). We generated a total of eight separate OLS models (table 2) to examine the associations between the four hypothesised protective factors and their potentially moderating relationships for each of the two outcome variables (mental and physical health) after accounting for controls. Tests of moderation included a multiplicative interaction term for each protective variable × ACE scores.

Table 1

Adverse childhood experiences among American Indian adults living with type 2 diabetes

	Never/No	At least once/Yes
When you were growing up, did you live with a household member who was a problem drinker or alcoholic or misused street or prescription drugs? (n=181)	51.9%	48.1%
When you were growing up, did you live with a household member who was depressed, mentally ill or suicidal? (n=180)	78.3%	21.7%
When you were growing up, did you live with a household member who was ever sent to jail or prison? (n=179)	68.2%	31.8%
When you were growing up, how often did you see or hear a parent or household member in your home being slapped, kicked, punched or beaten up? (n=180)	52.2%	47.8%
When you were growing up, how often did a parent, guardian or other household member yell, scream, swear at you, insult you or humiliate you? (n=182)	51.1%	48.9%
When you were growing up, how often did a parent, guardian or other household member spank you, slap you, kick you, punch you or beat you up? (n=179)	43.6%	56.4%
When you were growing up, how often did someone touch or fondle you in a sexual way when you did not want them to? (n=179)	76.5%	23.5%
When you were growing up, how often did someone make you touch their body in a sexual way when you did not want them to? (n=177)	86.4%	13.6%
When you were growing up, how often did someone actually have oral, anal or vaginal intercourse when you did not want them to? (n=181)	83.4%	16.6%

Table 2

Results from ordinary least squares regression analyses

	Mental health		Physical health		Mental health		Physical health		Mental health		Physical health		Mental health		Physical health
	N=176				N=177				N=176				N=177
	B (SE)	β	B (SE)	β	B (SE)	β	B (SE)	β	B (SE)	β	B (SE)	β	B (SE)	β	B (SE)	β
Age	−0.01 (0.01)	−0.08	−0.00 (0.01)	−0.03	−0.01 (0.01)	−0.09	−0.00 (0.01)	−0.04	−0.01 (0.01)	−0.06	−0.00 (0.01)	−0.02	−0.01 (0.01)	−0.07	−0.00 (0.01)	−0.01
Gender	−0.15 (0.15)	−0.07	−0.02 (0.13)	−0.01	−0.15 (0.14)	−0.08	−0.02 (0.13)	−0.01	−0.23 (0.14)	−0.12†	−0.05 (0.13)	−0.03	−0.13 (0.15)	−0.07	0.05 (0.13)	0.03
Per capita HH income	0.02 (0.01)	0.22**	0.02 (0.01)	0.18*	0.02(0.01)	0.20**	0.02 (0.01)	0.15*	0.02 (0.01)	0.15*	0.01 (0.01)	0.14†	0.02 (0.01)	0.20**	0.01 (0.01)	0.15†
ACEs	−0.09 (0.03)	−0.23**	−0.08 (0.03)	−0.22**	−0.08 (0.03)	−0.20**	−0.07 (0.03)	−0.20**	−0.06 (0.03)	−0.16*	−0.06 (0.03)	−0.17*	−0.07 (0.30)	−0.18*	−0.06 (0.03)	−0.17*
Spiritual activities	0.06 (0.03)	0.15*	0.03 (0.03)	0.07
Awareness of connectedness					0.07 (0.03)	0.18*	0.08 (0.03)	0.23**
Social support									0.50 (0.10)	0.35***	0.27 (0.10)	0.20**
Social support × ACEs											−0.07 (0.04)	−0.14†
Diabetes specific Support													0.03 (0.02)	0.10	0.06 (0.02)	0.21**
Diabetes support × ACEs															−0.02 (0.01)	−0.15*

*P≤0.05; **P≤0.01; ***P≤0.001.

†P≤0.10; two-tailed tests.

ACEs, adverse childhood experiences; HH, household.

Results

The average age of the study participants was 46.3 years (SD=12.2), mean per capita household income was $9767.00 and slightly more than half were female (55.7%). Frequencies of nine ACEs appear in table 1. An average of 3.05 (SD=2.46) ACEs were reported by participants and 81.9% (n=149) reported at least one ACE (not displayed).

Table 2 displays results of OLS regression analyses. As hypothesised (H1), across all models and controlling for gender, age and income, ACEs were negatively associated with mental and physical health. Also as hypothesised (H2), involvement in spiritual activities, stronger awareness of connectedness, social support and diabetes-specific support were all positively and significantly associated with self-reported mental and/or physical health in these models. Two of the control variables were also related to health in the multivariate analyses. Per capita household income was significantly and positively associated with mental and physical health across all models, and being female was associated with worse mental health in one model only.

We included interaction terms for each of the protective factors by ACEs index score for all independent variables; two of these emerged as statistically significant and are plotted in figures 1 and 2. As shown and in partial support of the third hypothesis (H3), social support and diabetes-specific support moderated the negative associations between ACEs and physical health. More specifically, physical health ratings were highest (better) for those reporting high support and low ACEs. Even when reporting higher ACEs, those in high support contexts still had better self-reported physical health than those with lower ACE scores but less supportive environments.

Self-rated physical health by ACE exposure and social support. ACE, adverse childhood experience.

Self-rated physical health by ACE exposure and diabetes-specific support. ACE, adverse childhood experience.

Discussion

This study adds important evidence to the limited research on ACEs and T2D among AIs who have a demonstrated higher prevalence of both compared with non-Indigenous US populations.7 17 In this multisite community study, cultural and social indicators were linked to better mental and physical health even when accounting for ACEs. We also found partial evidence for the moderating role of social support on associations between ACEs and health.

Approximately 82% of this AI sample reported experiencing at least one ACE. Our finding is much higher than the less than two-thirds of non-Native adults who report one or more ACEs in the now classic Kaiser/CDC study.34 Our percentage of 82% in this Midwest AI sample is consistent with the 78.1% minimum exposure rate (one or more ACE) reported by adolescent AIs on one northern plains reservation7 and the 86% of participants in a seven tribe study.8

As hypothesised, self-rated physical and mental health were negatively associated with ACEs for this sample of adults managing T2D, a complex chronic disease. This is not surprising given what is known from research showing strong associations between ACEs and health outcomes including T2D itself.35–37 As many AI/ANs exhibit drastic health disparities, these conclusions are useful to public health and tribal health systems for consideration in long-term diabetes reduction strategies. Primary and secondary prevention efforts targeting ACE exposures and intermediate health outcomes (eg, behavioural health), respectively, may reduce the prevalence of T2D within Tribal communities.

Higher levels of connectedness and social support were associated with better mental and physical health; diabetes-specific support was associated with better physical health, and spiritual activity involvement was related to better mental health. We thus advance the literature by documenting protective associations between Indigenous cultural factors (ie, involvement in spiritual activities and connectedness) and health that persist even when accounting for ACE exposures and demographics. Cultural connectedness, social support and traditional practices as wellness promoting factors are widely understood within Tribal communities. Therefore, this research supports Indigenous knowledge and underscores the critical importance of ‘a community-based prevention approach [that] recognises the inherent knowledge of community members and their expertise’.38

While social support has a well-documented positive impact on patients with diabetes,39–41 we add to this literature by demonstrating that adult support appears to moderate the harms of childhood adversities among AIs. That is, our findings suggest that adulthood social support networks may buffer the negative relationships between ACEs and health. This includes diabetes-specific support for AIs diagnosed with T2D. Diabetes interventions promoting socially supportive environments may prove useful for better prognosis.

Our findings also revealed a consistent, inverse relationship between per capita household income and health status. Poverty is a fundamental determinant of health driving health inequities,42 43 and pervasive poverty impacts many reservation communities including those participating in this study. The protective impact of increasing incomes documented here lends evidence to the importance of addressing structural issues related to health including unemployment and low-paying jobs.44 45 In addition, gender emerged as a significant correlate of mental health in one of the models where women reported worse mental health than men. Although this was not a robust finding in these analyses, it is consistent with prior research indicating higher levels of internalising symptoms in females relative to males.46

Limitations and future research

This study has several limitations for consideration. First, retrospective ACE studies may involve systematic error such as recall bias and false negative findings.47 Measurement and methodology differences hamper our ability to draw firm conclusions about the prevalence of AI/AN ACEs shown here and those documented nationally. ACEs reflected in this study are similar to most others in that they rely on a set of childhood stressors developed for mostly white, middle-class individuals with health insurance and who lived in Southern California; as such, results should be interpreted with these considerations in mind. A host of additional adversities including AI/AN specific ACEs are beginning to be addressed7 and deserve additional attention in future research. Given the variability in the types and severity of ACEs potentially experienced across cultures and community context, our estimates may be conservative and underscore the importance of culturally meaningful ACEs and placed-based assessments as a regular part of diabetes care and healthcare in general.7 Future research should include identification of specific forms and types of childhood stressors as well as the severity and frequency of the exposure that are particularly harmful to Native people alongside appraisal of sociocultural contexts that promote healing and well-being.

Conclusion

Our findings demonstrate how cultural and family supports relate to better health and in certain cases ameliorate the harms of ACEs among patients with T2D who face the complexities of managing chronic disease care. For policy-makers, our work suggests that funding allocations could support community-level resilience building activities and thus move beyond individual-level behaviour change (eg, diet, exercise). Specifically, programmes that enhance social support and include opportunities for cultural connectedness should be encouraged.

For health professionals, this research highlights the importance of life-course histories to assess childhood experiences and the lingering impact of childhood experiences on adult AI well-being. At the same time, providers including diabetes care professionals should encourage strategies for promoting help-seeking skills, social belonging and cultural activity participation for patients, particularly among those reporting a multitude of childhood adversities. Such support and encouragement could prove beneficial in promoting physical and mental health. These results also support the work of programme development staff in tribal communities who regularly engage in efforts to incorporate cultural group activities as wellness promotion and prevention mechanisms. These implications can inform wider health promotion strategies within and outside the healthcare system. For example, tribes may want to incorporate research findings into their design of trauma-informed care strategies and integrated behavioural healthcare. Finally, these findings have implications for health promotion across all cultures by highlighting the potential for sociocultural integration to improve human wellness.