Jonathan B Albilia1, Carlos Herrera-Vizcaino2, Hillary Weisleder3, Joseph Choukroun4, Shahram Ghanaati5. 1. a Private Practitioner and Attending, Division of Oral and Maxillofacial Surgery, Department of Dentistry , Jewish General Hospital , Montreal , Canada. 2. b Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery. FORM (Frankfurt Orofacial Regenerative Medicine) Lab , University Hospital Frankfurt Goethe University , Frankfurt am Main , Germany. 3. c Formerly Department of Anatomy and Cell Biology , McGill University, Montreal, QC, Canada; Currently, MD Candidate, New York Medical College , New York, NY , USA. 4. d Private Practitioner , Pain Therapy Center , Nice , France. 5. e Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, FORM (Frankfurt Orofacial Regenerative Medicine) Lab , University Hospital Frankfurt Goethe University , Frankfurt am Main , Germany.
Abstract
OBJECTIVE: To evaluate the clinical benefits of liquid platelet-rich fibrin (PRF) in patients with temporomandibular joint (TMJ) pain and dysfunction. METHODS: Forty-eight TMJs in 37 patients with painful internal derangement (ID) (Wilkes' I-V) were included. Patients were injected with 1.5-2cc of PRF within the superior joint space at 2-week intervals. Pain and subjective dysfunction were recorded using a visual analog scale. Statistical analyses were done using the ANOVA test. RESULTS: Thirty-three of 48 TMJs (69%) showed significant reduction in pain at 8 weeks, and at 3, 6, and 12 months (Responders). Fifteen of 48 TMJs (31%) did not improve (Non-responders). The best Responders to liquid PRF injections were ID stages Wilkes' IV (78.5%) and V (100%), compared to Wilkes' I (0%), II (47%), and III (33%). A non-significant, but notable decrease in dysfunction was found. CONCLUSION: Preliminary findings support that liquid PRF exhibits long-term analgesic effects in most patients with painful TMJ ID.
OBJECTIVE: To evaluate the clinical benefits of liquid platelet-rich fibrin (PRF) in patients with temporomandibular joint (TMJ) pain and dysfunction. METHODS: Forty-eight TMJs in 37 patients with painful internal derangement (ID) (Wilkes' I-V) were included. Patients were injected with 1.5-2cc of PRF within the superior joint space at 2-week intervals. Pain and subjective dysfunction were recorded using a visual analog scale. Statistical analyses were done using the ANOVA test. RESULTS: Thirty-three of 48 TMJs (69%) showed significant reduction in pain at 8 weeks, and at 3, 6, and 12 months (Responders). Fifteen of 48 TMJs (31%) did not improve (Non-responders). The best Responders to liquid PRF injections were ID stages Wilkes' IV (78.5%) and V (100%), compared to Wilkes' I (0%), II (47%), and III (33%). A non-significant, but notable decrease in dysfunction was found. CONCLUSION: Preliminary findings support that liquid PRF exhibits long-term analgesic effects in most patients with painful TMJ ID.
Authors: Lorenzo Moretti; Giuseppe Maccagnano; Michele Coviello; Giuseppe D Cassano; Andrea Franchini; Andrea Laneve; Biagio Moretti Journal: J Clin Med Date: 2022-05-08 Impact factor: 4.964
Authors: Nahed Ibrahim Ghoneim; Noha Ahmed Mansour; Sarah Ahmed Elmaghraby; Sally Elsayed Abdelsameaa Journal: J Dent Sci Date: 2021-08-21 Impact factor: 2.080
Authors: Sofia Iozon; Gabriela Valentina Caracostea; Emőke Páll; Olga Şoriţău; Ionuţ Daniel Mănăloiu; Adriana Elena Bulboacă; Mihaela Lupşe; Carmen Mihaela Mihu; Alexandra Livia Roman Journal: Rom J Morphol Embryol Date: 2020 Impact factor: 1.033