Mary Lourdes Montenegro1, Camila M Bonocher1, Juliana Meola1, Rafael L Portella2, Alfredo Ribeiro-Silva3, Mariangela O Brunaldi3, Rui Alberto Ferriani1, Julio Cesar Rosa-E-Silva4. 1. Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av. Bandeirantes 3900. Monte Alegre-Ribeirão Preto, São Paulo, 14049, Brazil. 2. Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, São Paulo, Brazil. 3. Department of Pathology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, São Paulo, Brazil. 4. Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av. Bandeirantes 3900. Monte Alegre-Ribeirão Preto, São Paulo, 14049, Brazil. juliocrs@usp.br.
Abstract
OBJECTIVE: Endometriosis is characterized by the growth of endometrial tissue outside the uterine cavity. The prevalence of endometriosis among women experiencing pain, infertility, or both is as high as 35% to 50%. The most common symptoms of endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Evidence has suggested that endometriosis symptoms result from a local inflammatory peritoneal reaction caused by ectopic endometrial implants that undergo cyclic bleeding. On the other hand, regular physical exercise seems to have protective effects against diseases that involve inflammatory processes such as type 2 diabetes and colon and breast cancer. On this basis, it is possible that the practice of physical exercise may have beneficial effects on endometriosis. Therefore, the objective of this study was to evaluate the possible anti-inflammatory effect of physical exercise on endometriosis experimentally induced in rats. STUDY DESIGN: Seventy female Wistar rats were divided into 7groups of 10 animals each. Animals performed light exercise (swimming once a week), moderate exercise (swimming 3 times a week), and intense exercise (swimming 5 times a week) before or after endometriosis induction. RESULTS: At the end of the experimental protocol, a reduction in the size of endometriotic lesions was observed after physical exercise regardless of its frequency, with a greater reduction in the groups practicing moderate and intense activity; an increase in FAS levels and a decrease in matrix metalloproteinases 9 and proliferating cell nuclear antigen (PCNA)levels was also observed. The immunohistochemistry results did not lead to conclusive results. As expected, oxidative stress was reduced in all groups. These results show that the practice of physical exercise could be beneficial, at least in part, for the treatment of endometriosis.
OBJECTIVE:Endometriosis is characterized by the growth of endometrial tissue outside the uterine cavity. The prevalence of endometriosis among women experiencing pain, infertility, or both is as high as 35% to 50%. The most common symptoms of endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Evidence has suggested that endometriosis symptoms result from a local inflammatory peritoneal reaction caused by ectopic endometrial implants that undergo cyclic bleeding. On the other hand, regular physical exercise seems to have protective effects against diseases that involve inflammatory processes such as type 2 diabetes and colon and breast cancer. On this basis, it is possible that the practice of physical exercise may have beneficial effects on endometriosis. Therefore, the objective of this study was to evaluate the possible anti-inflammatory effect of physical exercise on endometriosis experimentally induced in rats. STUDY DESIGN: Seventy female Wistar rats were divided into 7groups of 10 animals each. Animals performed light exercise (swimming once a week), moderate exercise (swimming 3 times a week), and intense exercise (swimming 5 times a week) before or after endometriosis induction. RESULTS: At the end of the experimental protocol, a reduction in the size of endometriotic lesions was observed after physical exercise regardless of its frequency, with a greater reduction in the groups practicing moderate and intense activity; an increase in FAS levels and a decrease in matrix metalloproteinases 9 and proliferating cell nuclear antigen (PCNA)levels was also observed. The immunohistochemistry results did not lead to conclusive results. As expected, oxidative stress was reduced in all groups. These results show that the practice of physical exercise could be beneficial, at least in part, for the treatment of endometriosis.
Authors: Hye Won Chung; Ji Young Lee; Hye-Sung Moon; Sung Eun Hur; Mi Hye Park; Yan Wen; Mary Lake Polan Journal: Fertil Steril Date: 2002-10 Impact factor: 7.329
Authors: Annemiek W Nap; Patrick G Groothuis; Ayse Y Demir; Johannes L H Evers; Gerard A J Dunselman Journal: Best Pract Res Clin Obstet Gynaecol Date: 2004-04 Impact factor: 5.237
Authors: Bedayah Amro; Maria Eugenia Ramirez Aristondo; Shaima Alsuwaidi; Basma Almaamari; Zeinab Hakim; Muna Tahlak; Arnaud Wattiez; Philippe R Koninckx Journal: Int J Environ Res Public Health Date: 2022-05-31 Impact factor: 4.614
Authors: María Del Mar Salinas-Asensio; Olga Ocón-Hernández; Antonio Mundo-López; Carolina Fernández-Lao; Francisco M Peinado; Carmen Padilla-Vinuesa; Francisco Álvarez-Salvago; Paula Postigo-Martín; Mario Lozano-Lozano; Ana Lara-Ramos; Manuel Arroyo-Morales; Irene Cantarero-Villanueva; Francisco Artacho-Cordón Journal: Int J Environ Res Public Health Date: 2022-02-02 Impact factor: 3.390