Literature DB >> 3022860

A study of the effects of catabolin on cyclic adenosine monophosphate biosynthesis and prostaglandin E2 secretion in pig articular chondrocytes.

G J Carroll.   

Abstract

The effects of porcine leucocyte catabolin on prostaglandin E2 (PGE2) secretion and cyclic adenosine monophosphate (cAMP) production were examined in pig articular chondrocytes. Cells were cultured in monolayers on plastic substrates for either 1 or 6 days. Catabolin was found to stimulate PGE2 secretion markedly in all chondrocyte cultures, but had no effect on cAMP biosynthesis, irrespective of the duration of culture, time of exposure or concentration. It is concluded that in pig articular chondrocytes catabolin does not modulate cell function by a cAMP-dependent mechanism.

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Year:  1986        PMID： 3022860     DOI： 10.1093/rheumatology/25.4.359

Source DB:  PubMed          Journal:  Br J Rheumatol        ISSN： 0263-7103


  4 in total

1.  Evidence that responses of articular chondrocytes to interleukin-1 and basic fibroblast growth factor are not mediated by protein kinase C.

Authors:  K I Hulkower; H I Georgescu; C H Evans
Journal:  Biochem J       Date:  1991-05-15       Impact factor: 3.857

Review 2.  What's happened to catabolin?

Authors:  H Sheppeard; K G Couchman
Journal:  Rheumatol Int       Date:  1987       Impact factor: 2.631

3.  Requirements for the induction of the interleukin-2 receptor complex in a human pre-T-cell line.

Authors:  P D Salvati; S E Peroni; P R Ranford; U R Kees
Journal:  Immunology       Date:  1993-03       Impact factor: 7.397

4.  Phosphorylation of the small heat-shock protein is regulated by interleukin 1, tumour necrosis factor, growth factors, bradykinin and ATP.

Authors:  J Saklatvala; P Kaur; F Guesdon
Journal:  Biochem J       Date:  1991-08-01       Impact factor: 3.857
  4 in total

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