Liangshan Mu1, Yue Zhao1, Rong Li1, Yuchen Lai1, Jie Qiao2. 1. Centre for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalBeijing, China; National Clinical Research Centre for Obstetrics and GynecologyBeijing, China; Key Laboratory of Assisted Reproduction, Ministry of EducationBeijing, China; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive TechnologyBeijing, China; Beijing Advanced Innovation Centre for GenomicsBeijing, China; Peking-Tsinghua Centre for Life Sciences, Peking UniversityBeijing, China. 2. Centre for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalBeijing, China; National Clinical Research Centre for Obstetrics and GynecologyBeijing, China; Key Laboratory of Assisted Reproduction, Ministry of EducationBeijing, China; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive TechnologyBeijing, China; Beijing Advanced Innovation Centre for GenomicsBeijing, China; Peking-Tsinghua Centre for Life Sciences, Peking UniversityBeijing, China. Electronic address: jie.qiao@263.net.
Abstract
RESEARCH QUESTION: The aim was to investigate the metabolic profiles of women with normal weight but central obesity in polycystic ovary syndrome (PCOS). DESIGN: In total, 727 women with PCOS from a large-scale epidemiological survey were included. Diagnosis of PCOS was based on Rotterdam criteria. Subjects were categorized into four subgroups: (i) normal weight non-central obesity (NWNCO): body mass index (BMI) ≤18.5 kg/m2 to <25 kg/m2 and waist-to-hip ratio (WHR) <0.85; (ii) normal weight central obesity (NWCO): BMI ≤18.5 kg/m2 to <25 kg/m2 and WHR ≥0.85; (iii) obese non-central obesity (ONCO): BMI ≥25 kg/m2 and WHR <0.85; and (iv) obese central obesity (OCO): BMI ≥25 kg/m2 and WHR ≥0.85. BMI, WHR, blood pressure, glucose and lipid profiles were measured. RESULTS: NWCO subjects had significantly higher percentages of insulin resistance, high triglycerides and low high-density lipoprotein cholesterol (HDL-C) than NWNCO subjects (all P < 0.05), and similar percentages compared with ONCO subjects. Compared with the NWNCO group, the NWCO group had higher age-adjusted risks of insulin resistance, high triglycerides and low HDL-C (odds ratio [OR] = 3.83, 95% confidence interval [CI] = 2.23-6.58; OR = 1.66, 95% CI = 1.00-2.77, OR = 1.60, 95% CI = 1.11-2.30, respectively). CONCLUSIONS: PCOS women with normal weight but central obesity had increased risks of insulin resistance and dyslipidaemia compared with normal weight PCOS women without central obesity, suggesting that combining BMI with measurement of central obesity may provide better adiposity-related metabolic risk factor stratification in clinical practice than either method alone.
RESEARCH QUESTION: The aim was to investigate the metabolic profiles of women with normal weight but central obesity in polycystic ovary syndrome (PCOS). DESIGN: In total, 727 women with PCOS from a large-scale epidemiological survey were included. Diagnosis of PCOS was based on Rotterdam criteria. Subjects were categorized into four subgroups: (i) normal weight non-central obesity (NWNCO): body mass index (BMI) ≤18.5 kg/m2 to <25 kg/m2 and waist-to-hip ratio (WHR) <0.85; (ii) normal weight central obesity (NWCO): BMI ≤18.5 kg/m2 to <25 kg/m2 and WHR ≥0.85; (iii) obese non-central obesity (ONCO): BMI ≥25 kg/m2 and WHR <0.85; and (iv) obese central obesity (OCO): BMI ≥25 kg/m2 and WHR ≥0.85. BMI, WHR, blood pressure, glucose and lipid profiles were measured. RESULTS: NWCO subjects had significantly higher percentages of insulin resistance, high triglycerides and low high-density lipoprotein cholesterol (HDL-C) than NWNCO subjects (all P < 0.05), and similar percentages compared with ONCO subjects. Compared with the NWNCO group, the NWCO group had higher age-adjusted risks of insulin resistance, high triglycerides and low HDL-C (odds ratio [OR] = 3.83, 95% confidence interval [CI] = 2.23-6.58; OR = 1.66, 95% CI = 1.00-2.77, OR = 1.60, 95% CI = 1.11-2.30, respectively). CONCLUSIONS:PCOSwomen with normal weight but central obesity had increased risks of insulin resistance and dyslipidaemia compared with normal weight PCOSwomen without central obesity, suggesting that combining BMI with measurement of central obesity may provide better adiposity-related metabolic risk factor stratification in clinical practice than either method alone.
Authors: Małgorzata Kałużna; Agnieszka Nomejko; Aleksandra Słowińska; Katarzyna Wachowiak-Ochmańska; Katarzyna Pikosz; Katarzyna Ziemnicka; Marek Ruchała Journal: Endocr Connect Date: 2021-08-30 Impact factor: 3.335