Validation of QT Interval Correction Methods When a Drug Changes Heart Rate.

The QT interval is correlated with heart rate; therefore, the QT interval is usually corrected by heart rate when drug-induced QT effect is studied. Currently, there are many correction methods that use either fixed or data-driven approaches. The effectiveness of correction methods depends on many factors and varies from study to study. Statistical validation and comparisons need to be performed to determine the most appropriate correction method for each study. We examined different validation methods and explored a new approach to use when the testing drug changes heart rate.