Huanhuan Hu1, Tetsuya Mizoue2, Naoko Sasaki3, Takayuki Ogasawara3, Kentaro Tomita4, Satsue Nagahama5, Ai Hori6, Akiko Nishihara7, Teppei Imai7, Makoto Yamamoto8, Masafumi Eguchi9, Takeshi Kochi9, Toshiaki Miyamoto10, Toru Honda11, Tohru Nakagawa11, Shuichiro Yamamoto11, Hiroko Okazaki12, Akihiko Uehara13, Makiko Shimizu14, Taizo Murakami14, Keisuke Kuwahara15, Akiko Nanri16, Maki Konishi2, Isamu Kabe9, Seitaro Dohi12. 1. Department of Epidemiology and Prevention, National Center for Global Health and Medicine, Tokyo, Japan. Electronic address: hhu@hosp.ncgm.go.jp. 2. Department of Epidemiology and Prevention, National Center for Global Health and Medicine, Tokyo, Japan. 3. Mitsubishi Fuso Truck and Bus Corporation, Kanagawa, Japan. 4. Mitsubishi Plastics, Inc., Tokyo, Japan. 5. All Japan Labour Welfare Foundation, Tokyo, Japan. 6. Department of Global Public Health, University of Tsukuba, Ibaraki, Japan. 7. Azbil Corporation, Tokyo, Japan. 8. YAMAHA CORPORATION, Shizuoka, Japan. 9. Furukawa Electric Co., Ltd., Tokyo, Japan. 10. Nippon Steel & Sumitomo Metal Corporation Kimitsu Works, Chiba, Japan. 11. Hitachi, Ltd., Ibaraki, Japan. 12. Mitsui Chemicals, Inc., Tokyo, Japan. 13. Seijinkai Shizunai Hospital, Hokkaidō, Japan. 14. Mizue Medical Clinic, Keihin Occupational Health Center, Kanagawa, Japan. 15. Department of Epidemiology and Prevention, National Center for Global Health and Medicine, Tokyo, Japan; Teikyo University Graduate School of Public Health, Tokyo, Japan. 16. Department of Epidemiology and Prevention, National Center for Global Health and Medicine, Tokyo, Japan; Department of Food and Health Sciences, International College of Arts and Sciences, Fukuoka Women's University, Fukuoka, Japan.
Abstract
BACKGROUND AND AIMS: We aimed to examine the risk of cardiovascular disease (CVD) with persistent prediabetes during the last four years prior to a CVD event in a large occupational cohort in Japan. METHODS: We performed a nested case-control study using data from the Japan Epidemiology Collaboration on Occupational Health Study. A total of 197 registered cases of CVD were identified and matched individually with 985 controls according to age, sex, and worksite. Prediabetes was defined as fasting plasma glucose 100-125 mg/dL and/or HbA1c 5.7-6.4%. Persistent prediabetes was defined as having prediabetes at years one and four prior to the onset/index date; persistent normoglycemia was similarly defined. Associations between prediabetes and CVD risk were assessed using conditional logistic regression models. RESULTS: Compared with people with persistent normoglycemia over the four years prior to the onset/index date, the unadjusted odds ratio (95% confidence interval) for CVD was 2.88 (1.56, 5.32) for people with persistent prediabetes. After adjusting for BMI, smoking, hypertension, and dyslipidemia assessed four years before the onset/index date, the association was slightly attenuated to an OR (95% confidence interval) of 2.62 (1.31, 5.25). Prediabetes assessed at single time points was also associated with an elevated risk of CVD, with multivariable-adjusted odds ratio (95% confidence interval) of 1.72 (1.12, 2.64) and 2.13 (1.32, 3.43) for prediabetes at one and four years prior to the onset/index date, respectively. CONCLUSIONS: Prediabetes is associated with an increased risk of CVD. Identification and management of prediabetes are important for the prevention of CVD.
BACKGROUND AND AIMS: We aimed to examine the risk of cardiovascular disease (CVD) with persistent prediabetes during the last four years prior to a CVD event in a large occupational cohort in Japan. METHODS: We performed a nested case-control study using data from the Japan Epidemiology Collaboration on Occupational Health Study. A total of 197 registered cases of CVD were identified and matched individually with 985 controls according to age, sex, and worksite. Prediabetes was defined as fasting plasma glucose 100-125 mg/dL and/or HbA1c 5.7-6.4%. Persistent prediabetes was defined as having prediabetes at years one and four prior to the onset/index date; persistent normoglycemia was similarly defined. Associations between prediabetes and CVD risk were assessed using conditional logistic regression models. RESULTS: Compared with people with persistent normoglycemia over the four years prior to the onset/index date, the unadjusted odds ratio (95% confidence interval) for CVD was 2.88 (1.56, 5.32) for people with persistent prediabetes. After adjusting for BMI, smoking, hypertension, and dyslipidemia assessed four years before the onset/index date, the association was slightly attenuated to an OR (95% confidence interval) of 2.62 (1.31, 5.25). Prediabetes assessed at single time points was also associated with an elevated risk of CVD, with multivariable-adjusted odds ratio (95% confidence interval) of 1.72 (1.12, 2.64) and 2.13 (1.32, 3.43) for prediabetes at one and four years prior to the onset/index date, respectively. CONCLUSIONS:Prediabetes is associated with an increased risk of CVD. Identification and management of prediabetes are important for the prevention of CVD.
Authors: Demetria Hubbard; Lisandro D Colantonio; Rikki M Tanner; April P Carson; Swati Sakhuja; Byron C Jaeger; Robert M Carey; Laura P Cohen; Daichi Shimbo; Mark Butler; Alain G Bertoni; Aisha T Langford; John N Booth; Jolaade Kalinowski; Paul Muntner Journal: Diabetes Care Date: 2019-10-07 Impact factor: 19.112
Authors: Raffaele Palladino; Adam G Tabak; Kamlesh Khunti; Jonathan Valabhji; Azeem Majeed; Christopher Millett; Eszter P Vamos Journal: BMJ Open Diabetes Res Care Date: 2020-04